Inhibition of macrophage nitric oxide production by tetrahydrocannabinol in vivo and in vitro

International Journal of Immunopharmacology

Volumn 18, Issue 12, 1996, Pages 749-752

  Coffey, Ronald G ^a   Snella, Elizabeth ^a   Johnson, Karen ^a   Pross, Susan ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Interferon ; Lipopolysaccharide; Macrophage; Nitric oxide; Tetrahydrocannabinol

Indexed keywords

GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TETRAHYDROCANNABINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FEMALE; HOST RESISTANCE; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030439575     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)85557-9     Document Type: Article

References (24)

1. Burnette-Curley, D., Marciano-Cabral, F., Fischer-Stenger, K. & Cabral, G. A. (1993) Delta-9-tetrahydrocannabinol inhibits cell contact-dependent cytotoxicity of Bacillus Calmette-Guerin-activated macrophages. Int. J. Immunopharmac., 15, 371-382.
2. Diaz, S., Specter, S. & Coffey, R. (1993) Suppression of lymphocyte adenosine 3′:5′-cyclic monophosphate (cAMP) by Δ-9-tetrahydrocannabinol. Int. J. Immunopharmac., 15, 523-532.
3. Diaz, S., Specter, S., Vanderhoek, J. Y. & Coffey, R. G. (1994) The effect of Δ-9-tetrahydro-cannabinol on arachidonic acid metabolism in human peripheral blood mononuclear cells. J. Pharmac. exp. Therap., 268, 1289-1296.
4. Ding, A. H., Nathan, C. F. & Stuehr, D. J. (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol., 141, 2407-2412.
5. Felder, C. C., Veluz, J. S., Williams, H. L., Briley, E. M. & Matsuda, L. (1992) Cannabinoid agonists stimulate both receptor- and non-receptor mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones. Mol. Pharmac., 42, 838-845.
6. Fischer-Stenger, K., Dove Pettit, D. A. & Cabral, G. A. (1993) Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-α: suppression of post-translational events. J. Pharmac. exp. Therap., 267, 1558-1565.
7. 15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138.
8. Higuchi, M., Higashi, N., Taki, H. & Osawa, T. (1990) Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms os activated macrophages. J. Immunol., 144, 1425-1431.
9. 1 in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol. Pharmac., 29, 307-313.
10. Kaminski, N. E. (1994). Mechanisms of immune modulation by cannabinoids. In Immunotoxicology and Immunopharmacology, Second Edition (eds Dean, J. H., Luster, M. I., Munson, A. E., & Kimber, I.), pp. 349-362. Raven Press, New York.
11. Kaminski, N. E., Abood, M. E., Kessler, F. K., Martin, B. R. & Schatz, A. R. (1992) Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol. Pharmac., 42, 736-742.
12. Kaminski, N. E., Koh, W. S., Yang, K. H., Lee, M. & Kessler, F. K. (1994) Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G protein coupled mechanism. Biochem. Pharmac., 48, 1899-1908.
13. Klein, T. W., Newton, C., Widen, R. & Friedman, H. (1993) Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila. J. Pharmac. exp. Therap., 267, 635-640.
14. Laychock, S. G., Hoffman, J. M., Meisel, E. & Bilgin, S. (1986) Pancreatic islet arachidonic acid turnover and metabolism and insulin release in response to delta-9-tetrahydrocannabinol. Biochem. Pharmac., 25, 2003-2008.
15. Lopez-Cepero, M., Friedman, M., Klein, T. & Friedman, H. (1986) Tetrahydrocannabinol-induced suppression of macrophage spreading and phagocytic activity in vitro. J. Leukoc. Biol., 39, 679-686.
16. MacMickling, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q. -W., Sokol, K., Hutchinson, N., Chen, H. & Mudgett, J. S. (1995) Altered responses to bacterial infection and endotoxic shock in ice lacking inducible nitric oxide synthase. Cell, 81, 641-650.
17. Munro, S., Thomas, K. L. & Abu-Shaar, M. (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 61-65.
18. Nathan, C. F. & Hibbs, J. B. Jr. (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opinion Immunol., 3, 65-70.
19. Newton, C. A., Klein, T. W. & Friedman, H. (1994) Secondary immunity to Legionella pneumophila and TH1 activity are suppressed by Δ9-tetrahydrocannabinol injection. Infection Immunity, 62, 4015-4020.
20. Pross, S., Nakano, Y., Smith, J., Widen, R., Rodriguez, R., Newton, C. & Friedman, H. (1992) Suppressive effect of tetrahydrocannabinol on specific T cell subpopulations in the thymus. Thymus, 19, 97-104.
21. Specter, S., Lancz, G., Westrich, G. & Friedman, H. (1991) Delta-9-tetrahydrocannabinol augments murine retroviral induced immunosuppression and infection. Int. J. Immunopharmac., 13, 411-417.
22. Vandeloosdrecht, A. A., Beelen, R. H. J., Ossenkoppele, G. J., Broekhoven, M. O. & Langenhuijsen, M. M. A. C. (1994) A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia. J. Immunol. Meth., 174, 311-320.
23. Weinberg, J. B., Granger, D. L., Pisetsky, D. S., Seldin, M. F., Misukonis, M. A., Mason, S. N., Pippen, A. M., Ruiz, P., Wood, E. R. & Gilkeson, G. S. (1994) The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease-increased nitric oxide production and nitric oxide synthase expression in MRL-Lpr/Lpr Mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered N-G-monomethyl-L-arginine. J. exp. Med., 179, 651-660.
24. Zheng, Z. M., Specter, S. & Friedman, H. (1992) Inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse and human macrophages. Int. J. Immunopharmac., 14, 1445-1452.