Effects of the spin trap-α-phenyl-N-tert-butyl nitrone (PBN) in transient forebrain ischaemia in the rat

Acta Physiologica Scandinavica

Volumn 157, Issue 1, 1996, Pages 41-51

  Pahlmark, K ^a,b   Siesjo B K ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Brain damage; Forebrain ischaemia; Free radicals; spin traps

Indexed keywords

2 SULFONYL N TERT BUTYL ALPHA PHENYLNITRONE; FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; FOREBRAIN; HEART INFARCTION SIZE; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0029998225     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1996.440167000.x     Document Type: Article

References (58)

1. Akopov, S.E., Sercombe, R. & Seylaz, J. 1994. Leukocyte-induced acute endothelial dysfunction in middle cerebral artery in rabbits. Stroke 25, 2246-2252.
2. Auer, R.N., Wieloch, T., Olsson, Y. & Siesjö, B.K. 1984. The distribution of hypoglycemic brain damage. Acta Neuropathol (Berl) 64, 177-191.
3. Buchan, A. & Pulsinelli, W.A. 1990. Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neurosci 10, 311-316.
4. Cao, W., Carney, J.M., Duchon, A., Floyd, R.A. & Chevion, M. 1988. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88, 233-238.
5. Cao, X. & Phillis, J.W. 1994. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Res 644, 267-272.
6. Carney, J.M. & Floyd, R.A. 1991. Protection against oxidative damage to CNS by α-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers. J Mol Neurosci 3, 47-57.
7. Chen, G., Bray, T.M., Janzen, E.G. & McCay, P.B. 1990a. Excretion, metabolism and tissue distribution of a spin trapping agent, α-phenyl-N-tert-butyl-nitrone (PBN) in rats. Free Rad Res Comms 9, 317-323.
8. Chen, G., Griffin, M., Poyer, J.L., McCay, P.B. & Bourne, D.W.A. 1990b. HPLC procedure for the pharmacokinetic study of the spin-trapping agent, α-phenyl-N-tert-butyl nitrone (PBN). Free Rad Biol Med 8, 93-98.
9. Cheng, H.-Y., Liu, T., Feuerstein, G. & Barone, F.C. 1993. Distribution of spin-trapping compounds in rat blood and brain: in vivo microdialysis determination. Free Rad Biol Med 14, 243-250.
10. Chopp, M., Zhang, R.L., Chen, H., Li, Y., Jiang, N. & Rusche, J.R. 1994. Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke 25, 869-876.
11. Clough-Helfman, C. & Phillis, J.W. 1991. The free radical trapping agent N-tert-butyl-α-phenylnitrone (PBN) attenuates cerebral ischemic injury in gerbils. Free Rad Res Comms 15, 177-186.
12. del Zoppo, G.J., Schmid-Schönbein, G.W., Mori, E., Copeland, B.R. & Chang, C.-M. 1991. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22, 1276-1283.
13. Ekholm, A., Katsura, K., Kristián, T., Liu, M., Folbergrová, J. & Siesjö, B.K. 1993. Coupling of cellular energy state and ion homeostasis during recovery following brain ischemia. Brain Res 604, 185-191.
14. Ennis, S.R., Keep, R.F., Schielke, G.P. & Betz, A.L. 1990. Decrease in perfusion of cerebral capillaries during incomplete ischemia and reperfusion. J Cereb Blood Flow Metab 10, 213-220.
15. Feuerstein, G.Z., Liu, T. & Barone, F.C. 1994. Cytokines, inflammation, and brain injury: role of tumor necrosis factor-α. Cerebrovasc Brain Metab Rev 6, 341-360.
16. Floyd, R.A. 1990. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4, 2587-2597.
17. Folbergrová, J., Kiyota, Y., Pahlmark, K., Memezawa, H., Smith, M.-L. & Siesjö, B.K. 1993. Does ischemia with reperfusion lead to oxidative damage to proteins in the brain? J Cereb Blood Flow Metab 13, 145-152.
18. Folbergrová, J., Norberg, K., Quistorff, B. & Siesjö, B.K. 1975. Carbohydrate and amino acid metabolism in rat cerebral cortex in moderate and extreme hypercapnia. J Neurochem 25, 457-462.
19. Garcia, J.H., Liu, K.F., Yoshida, Y., Lian, J., Chen, S. & del Zoppo, G.J. 1994. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am J Pathol 144, 188-199.
20. Gisselsson, L., Smith, M.-L. & Siesjö, B.K. 1992. Influence of preischemic hyperglycemia on osmolality and early postischemic edema in the rat brain. J Cereb Blood Flow Metab 12, 809-816.
21. Hallenbeck, J.M. 1996. Inflammatory reactions at the blood-endothelial interface in acute stroke. In: B.K. Siesjö & T. Wieloch (eds) Advances in Neurology. Raven, New York, in press.
22. Halliwell, B. 1992. Reactive oxygen species and the central nervous system. J Neurochem 59, 1609-1623.
23. Hess, D.C., Zhao, W., Carroll, J., McEachin, M. & Buchanan, K. 1994. Increased expression of ICAM-1 during reoxygenation in brain endothelial cells. Stroke 25, 1463-1468.
24. Hillered, L. & Ernster, L. 1983. Respiratory activity of isolated rat brain mitochondria following in vitro exposure to oxygen radicals. J Cereb Blood Flow Metab 3, 207-214.
25. Hillered, L., Siesjö, B.K. & Arfors, K.-E. 1984. Mitochondrial response to transient forebrain ischemia and recirculation in the rat. J Cereb Blood Flow Metab, 4, 438-446.
26. Hillered, L., Smith, M.-L. & Siesjö, B.K. 1985. Lactic acidosis and recovery of mitochondrial function following forebrain ischemia in the rat. J Cereb Blood Flow Metab 5, 259-266.
27. Ito, U., Spatz, M., Walker, J.T. & Klatzo, I. 1975. Experimental cerebral ischemia in Mongolian gerbils I. Light microscopic observations. Acta Neuropath (Berl) 32, 209-223.
28. Kontos, H.A. 1985. Oxygen radicals in cerebral vascular injury. Circ Res 57, 508-516.
29. Kontos, H.A. 1989. Oxygen radicals in cerebral ischemia. In: M. Ginsberg & W. Dietrich (eds) Cerebrovascular Diseases, pp. 365-371. Raven Press, New York.
30. Kontos, H.A. & Povlishock, J.T. 1986. Oxygen radicals in brain injury. Central Nervous System Trauma 3, 257-263.
31. Krause, G.S., DeGracia, D.J., Skjaerlund, J.M. & O'Neil, B. 1992. Assessment of free radical-induced damage in brain proteins after ischemia and reperfusion. Resuscitation 23, 59-69.
32. Kukreja, R.C., Kontos, H.A., Hess, M.L. & Ellis, E.F. 1986. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res 59, 612-619.
33. Kuroiwa, T., Bonnekoh, P. & Hossman, K.-A. 1990. Prevention of postischemic hyperthermia prevents ischemic injury of CA1 neurons in gerbils. J Cereb Blood Flow Metab 10, 550-556.
34. Malis, C.D. & Bonventre, J.V. 1986. Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for postischemic and toxic mitochondrial damage. J Biol Chem 261, 14201-14208.
35. Matsuyama, T., Michishita, H., Nakamura, H., Tsuchiyama, M., Shimizu, S., Watanabe, K. & Sugita, M. 1993. Induction of copper-zinc superoxide dismutase in gerbil hippocampus after ischemia. J Cereb Blood Flow Metab 13, 135-144.
36. Oliver, C.N., Starke-Reed, P.E., Stadtman, E.R., Liu, G.J., Carney, J.M. & Floyd, R.A. 1990. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci USA 87, 5144-5147.
37. Pahlmark, K., Folbergrová, J., Smith, M.-L. & Siesjö, B.K. 1993. Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats. Stroke 24, 731-737.
38. Phillis, J.W. & Clough-Helfman, C. 1990. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN). Neurosci Lett 116, 315-319.
39. Pulsinelli, W.A., Brierley, J.B. & Plum, F. 1982. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11, 491-498.
40. Rehncrona, S., Mela, L. & Siesjö, B.K. 1979. Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia. Stoke 10, 437-446.
41. Sen, S. & Phillis, J.W. 1993. Alpha-phenyl-tert-butyl-nitrone (PBN) attenuates hydroxyl radical production during ischemia-reperfusion injury of rat brain: an EPR study. Free Rad Res Comms 19, 255-265.
42. Siesjö, B.K., Agardh, C.-D. & Bengtsson, F. 1989. Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1, 165-211.
43. Siesjö, B.K., Katsura, K., Pahlmark, K. & Smith, M.-L. 1992. The multiple causes of ischemic brain damage: a speculative synthesis. In: J. Krieglstein & H. Oberpichler (eds) Pharmacology of Cerebral Ischemia 1992, pp. 511-525. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
44. Siesjö, B.K., Katsura, K., Zhao, Q., Folbergrová, J., Pahlmark, K., Siesjö, P. & Smith, M.-L. 1995a. Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma 12, 943-956
45. Siesjö, B.K., Kristián, T. & Katsura, K. 1995b. The role of calcium in delayed postischemic brain damage. In: M. Moskowitz (ed.) The Nineteenth Princeton Conference. Butterworth-Heineman, Boston, in press.
46. Siesjö, B.K., Lundgren, J. & Pahlmark, K. 1990. The role of free radicals in ischemic brain damage: a hypothesis. In: J. Krieglstein & H. Oberpichler (eds) Pharmacology of Cerebral Ischemia 1990, pp. 319-323. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
47. Sims, N.R. & Pulsinelli, W.A. 1987. Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat. J Neurochem 49, 1367-1374.
48. Smith, M.-L., Auer, R.N. & Siesjö, B.K. 1984a. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropath (Berl) 64, 319-332.
49. Smith, M.-L., Bendek, G., Dahlgren, N., Rosén, I., Wieloch, T. & Siesjö, B.K. 1984b. Models for studying long-term recovery following forebrain ischemia in the rat: 2. A 2-vessel occlusion model. Acta Neurol Scand 69, 385-401.
50. Theilen, H. & Kuschinsky, W. 1992. Fluorescence labeling of the capillary network in rat brains. J Cereb Blood Flow Metab 12, 347-350.
51. Theilen, H., Schröck, H. & Kuschinsky, W. 1994. Gross persistence of capillary plasma perfusion after middle cerebral artery occlusion in the rat brain. J Cereb Blood Flow Metab 14, 1055-1061.
52. Thomas, W.S., Mori, E., Copeland, B.R., Yu, J.-Q., Morrissey, J.H. & del Zoppo, G.J. 1993. Tissue factor contributes to microvascular defects after focal cerebral ischemia. Stroke 24, 847-854.
53. Traystman, R.J., Kirsch, J.R. & Koehler, R.C. 1991. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 71, 1185-1195.
54. Warner, D.S., Smith, M.-L. & Siesjö, B.K. 1987. Ischemia in normo- and hyperglycemic rats: effects on brain water and electrolytes. Stroke 18, 464-471.
55. Wasil, M., Halliwell, B., Grootveld, M., Moorhouse, C.P., Hutchison, D.C.S. & Baum, H. 1987. The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Biochem J 243, 867-870.
56. Yue, T.-L., Gu, J.-L., Lysko, P.G., Cheng, H.-Y., Barone, F.C. & Feuerstein, G. 1992. Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res 574, 193-197.
57. Zhao, Q., Pahlmark, K., Smith, M.-L. & Siesjö, B.K. 1994. Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 152, 349-350.
58. Zini, I., Tomasi, A., Grimaldi, R., Vannini, V. & Agnati, L.F. 1992. Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis. Neurosci Lett 138, 279-282.