Inhibition by phenyl N-tert-butyl nitrone of early phase carcinogenesis in the livers of rats fed a choline-deficient, L-amino acid-defined diet

Cancer Research

Volumn 58, Issue 20, 1998, Pages 4548-4551

  Nakae, Dai ^a   Kotake, Yashige ^b   Kishida, Hideki ^a   Hensley, Kenneth L ^b   Denda, Ayumi ^a   Kobayashi, Yozo ^a   Kitayama, Wakashi ^a   Tsujiuchi, Toshifumi ^a   Sang, Hong ^b   Stewart, Charles A ^b   Tabatabaie, Tahereh ^b   Floyd, Robert A ^b   Konishi, Yoichi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; CHOLINE; CYCLOOXYGENASE 2; GLUTATHIONE TRANSFERASE; N TERT BUTYL ALPHA PHENYLNITRONE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER PREVENTION; CARCINOGENESIS; CATALYSIS; CONNECTIVE TISSUE; ENZYME ACTIVITY; LIVER CANCER; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN RESTRICTION; RAT;

AMINO ACIDS; ANIMALS; CHOLINE DEFICIENCY; CYCLOOXYGENASE 2; FREE RADICAL SCAVENGERS; GLUTATHIONE; ISOENZYMES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITROGEN OXIDES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR;

EID: 0032532382     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Miyajima, T., and Kotake, Y. Spin trapping agent, phenyl N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochem. Biophys. Res. Commun., 215: 114-121, 1995.
2. Tamir, S., and Tannenbaum, S. R. The role of nitric oxide (NO·) in the carcinogenic processes. Biochim. Biophys. Acta, 1288: F31-F36, 1996.
3. Xie, Q-W., Kashiwabara, Y., and Nathan, C. Role of transcription factor NF-KB/Rel in induction of nitric oxide synthase. J. Biol. Chem., 269: 4705-4708, 1994.
4. Hong, W. K., and Sporn, M. B. Recent advances in chemoprevention of cancer. Science (Washington, DC), 278: 1073-1077, 1997.
5. Schmedtje, J. F., Jr., Ji, Y. S., Liu, W., SuBois, R. N., and Runge. M. S. Hypoxia induces cyclooxygenase-2 via the NF-KB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem., 272: 601-608, 1997.
6. Salvemini, D., Misko, T. P., Masferrer, J. L., Seibert, K., Currie, M. G., and Needleman, P. Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA, 90: 7240-7244, 1993.
7. Nakae, D., Mizumoto, Y., Yoshiji, H., Andoh, N., Horiguchi, K., Kobayashi, E., Endoh, T., Shimoji, N., Tamura, K., Tsujiuchi, T., Denda, A., and Konishi, Y. Different roles of 8-hydroxyguanine formation and 2-thiobarbituric acid-reacting substances generation in the early phase of liver carcinogenesis induced by a cholinedeficient, L-amino acid-defined diet in rats. Jpn. J. Cancer Res., 85: 499-505, 1994.
8. Denda, A., Endoh, T., Kitayama, W., Tang, Q., Noguchi, O., Kobayashi, Y., Akai, H., Okajima, E., Tsujiuchi, T., Tsutsumi, M., Nakae, D., and Konishi, Y. Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzymealtered nodules by a choline-deficient, L-amino acid-defined diet in rats. Carcinogenesis (Lond.), 18: 1921-1930, 1997.
9. Kobayashi, Y., Nakae, D., Akai, H., Kishida, H., Okajima, E., Kitayama, W., Denda, A., Tsujiuchi, T., Murakami, A., Koshimizu, K., Ohigashi, H., and Konishi, Y. Prevention by 1′-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet. Carcinogenesis (Lond.), 19: in press, 1998.
10. Ohata, T., Fukuda, K., Murakami, A., Ohigashi, H., Sugimura, T., and Wakabayashi, K. Inhibition by 1′-acetoxychavicol acetate of lipopolysaccharide- nd interferon-γ-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells. Carcinogenesis (Lond.), 19: 1007-1012, 1998.
11. Rushmore, T. H., Ghazarian, D. M., Subrahmanyan, V., Farber, E., and Ghoshal, A. K. Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline-devoid low-methionine diet. Cancer Res., 47: 6731-6740, 1987.
12. Janzen, E. G., and Haire, D. L. Two decades of spin trapping. In: D. D. Tanner (ed.), Advances in Free Radical Chemistry, pp. 253-295. Greenwich, CT: JAI Press, 1990.
13. Habig, W. H., Pabst, M. J., and Jakoby, W. B. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem., 25: 7130-7139, 1974.
14. Brandt, R., and Keston, A. S. Synthesis of diacetyldichlorofluorescein: a stable agent for fluorometric analysis. Anal. Biochem., 11: 6-9, 1965.
15. Nakae, D., Mizumoto, Y., Kobayashi, E., Noguchi, O, and Konishi, Y. Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue. Cancer Lett., 97: 233-239, 1995.
16. Powell, W. S. Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. Prostaglandins, 20: 947-957, 1980.
17. Floyd, R. A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis (Lond.), 11: 1447-1450, 1990.
18. Kurumbail, R. G., Stevens, A. M., Gierse, J. K., McDonald, J. J., Stegeman, R. A., Park, J. Y., Gildehaus, D., Mitashiro, J. M., Penning, T. D., Seibert, K., Isakson, P. C., and Stallings, W. C. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature (Lond.), 384: 644-648, 1996.
19. 2 in the liver of rats fed a choline deficient diet: possible involvement in liver tumor promotion. Cancer Lett., 46: 129-135, 1989.
20. Lopp, E., and Ghosh, S. Inhibition of NF-KB by sodium salicylate and aspirin. Science (Washington, DC), 265: 956-959, 1994.
21. Christman, J. K. Lipotrope deficiency and persistent changes in DNA methylation: lipotrope deficiency and DNA methylation. Adv. Exp. Med. Biol., 375: 97-106, 1995.
22. Tsujiuchi, T., Kobayashi, E., Nakae, D., Mizumoto, Y., Andoh, N., Kitada, H., Ohashi, K., Fukuda, T., Kido, A., Tsutsumi, M., Denda, A., and Konishi, Y. Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient, L-amino acid-defined diet and ethionine in rats. Jpn. J. Cancer Res., 86: 1136-1142, 1995.
23. Lombardi, B., and Smith, M. L. Tumorigenesis, protooncogene activation, and other gene abnormalities in methyl deficiency. J. Nutr. Biochem., 5: 2-9, 1994.