Asthma: T-bet - A master controller?

Current Biology

Volumn 12, Issue 9, 2002, Pages

  Robinson, Douglas S ^a   Lloyd, Clare M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0037197942     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00830-8     Document Type: Review

References (20)

1. Th-2 cytokines in allergic disease
2. Commit ye helpers
3. A novel transcription factor, T-bet, directs Th1 lineage commitment
4. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
5. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
6. Control of T helper cell differentiation - In search of master genes
7. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
8. GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
9. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
10. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
11. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
12. Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo
13. In vitro generation of interleukin-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type-1 (Th1) and Th2-inducing cytokines
14. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
15. The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity
16. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness and the late asthmatic response
17. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
18. T cells from human allergen-induced late asthmatic responses express IL-12 receptor beta 2 subunit mRNA and respond to IL-12 in vitro
19. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness and the late asthmatic response
20. Mouse models of allergic airway disease