메뉴 건너뛰기




Volumn 16, Issue 5, 1996, Pages 2496-2503

Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles

Author keywords

[No Author keywords available]

Indexed keywords

NEUROFIBROMIN;

EID: 0029880365     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.2496     Document Type: Article
Times cited : (29)

References (42)
  • 1
    • 0025201012 scopus 로고
    • The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
    • Baltester, R., D. Marchuck, M. Boguski, A. Sauline, R. Letcher, M. Wigler, and F. Collins. 1990. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63:851-859.
    • (1990) Cell , vol.63 , pp. 851-859
    • Baltester, R.1    Marchuck, D.2    Boguski, M.3    Sauline, A.4    Letcher, R.5    Wigler, M.6    Collins, F.7
  • 4
    • 0025940629 scopus 로고
    • The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest
    • Chien, C.-T., P. L. Bartel, R. Sternglanz, and S. Fields. 1991. The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA 88:9578-9582
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9578-9582
    • Chien, C.-T.1    Bartel, P.L.2    Sternglanz, R.3    Fields, S.4
  • 5
    • 0025139385 scopus 로고
    • Different kinetic properties of the two mutants, RAS2IIe152 and RAS2Val19, that suppress the CDC25 requirement in RAS/adenylate cyclase pathway in Saccharomyces cerevisiae
    • Créchet, J.-B., P. Poullet, J. Camonis, M. Jacquet, and A. Parmeggiani. 1990. Different kinetic properties of the two mutants, RAS2IIe152 and RAS2Val19, that suppress the CDC25 requirement in RAS/adenylate cyclase pathway in Saccharomyces cerevisiae. J. Biol. Chem. 265:1563-1568.
    • (1990) J. Biol. Chem. , vol.265 , pp. 1563-1568
    • Créchet, J.-B.1    Poullet, P.2    Camonis, J.3    Jacquet, M.4    Parmeggiani, A.5
  • 6
    • 0026528368 scopus 로고
    • Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
    • DeClue, J. E., A. G. Papageorge, J. Fletcher, S. R. Diehl, N. Ratner, W. C. Vass, and D. R. Lowy. 1992 Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 69:265-273.
    • (1992) Cell , vol.69 , pp. 265-273
    • DeClue, J.E.1    Papageorge, A.G.2    Fletcher, J.3    Diehl, S.R.4    Ratner, N.5    Vass, W.C.6    Lowy, D.R.7
  • 8
    • 0024406857 scopus 로고
    • A novel genetic system to detect protein-protein interactions
    • Fields, S., and O.-K. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature (London) 340:245-246.
    • (1989) Nature (London) , vol.340 , pp. 245-246
    • Fields, S.1    Song, O.-K.2
  • 9
    • 0028019830 scopus 로고
    • The minimal fragments of c-Raf-1 and NF1 that can suppiess v-Ha-Ras-induced malignant phenotype
    • Fridman, M., A. Tikoo, M. Varga, A. Murphy, M. S. Nur-E-Kamal, and H. Maruta. 1994. The minimal fragments of c-Raf-1 and NF1 that can suppiess v-Ha-Ras-induced malignant phenotype. J. Biol. Chem. 269:30105-30108.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30105-30108
    • Fridman, M.1    Tikoo, A.2    Varga, M.3    Murphy, A.4    Nur-E-Kamal, M.S.5    Maruta, H.6
  • 10
    • 0000811664 scopus 로고
    • Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules
    • Gibbs, J. B., I. S. Sigal, M. Poe, and E. M. Scolnick. 1984. Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules. Proc. Natl. Acad. Sci. USA 81:5704-5708.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5704-5708
    • Gibbs, J.B.1    Sigal, I.S.2    Poe, M.3    Scolnick, E.M.4
  • 11
    • 0027503594 scopus 로고
    • Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis
    • Gutmann, D. H., M. Boguski, D. Marchuk, M. Wigler, F. S. Collins, and R. Ballester. 1993. Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis Oncogene 8:761-769.
    • (1993) Oncogene , vol.8 , pp. 761-769
    • Gutmann, D.H.1    Boguski, M.2    Marchuk, D.3    Wigler, M.4    Collins, F.S.5    Ballester, R.6
  • 12
    • 0028028433 scopus 로고
    • Structural analysis of the Ras GTPase activating protein catalytic domain by semirandom mutagenesis: Implications for a mechanism of interaction with Ras-GTP
    • Hettich, L., and M. Marshall. 1994. Structural analysis of the Ras GTPase activating protein catalytic domain by semirandom mutagenesis: implications for a mechanism of interaction with Ras-GTP. Cancer Res. 54:5438-5444.
    • (1994) Cancer Res. , vol.54 , pp. 5438-5444
    • Hettich, L.1    Marshall, M.2
  • 13
    • 0024520745 scopus 로고
    • Site-directed mutagenesis by overlap extension using the polymerase chain reaction
    • Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
    • (1989) Gene , vol.77 , pp. 51-59
    • Ho, S.N.1    Hunt, H.D.2    Horton, R.M.3    Pullen, J.K.4    Pease, L.R.5
  • 14
    • 0027979813 scopus 로고
    • Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function
    • Johnson, M. R., J. E. DeClue, S. Felzmann, W. C. Vass, G. Xu, R. Whits, and D. R. Lowy. 1994 Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. Mol. Cell. Biol. 14:641-645.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 641-645
    • Johnson, M.R.1    DeClue, J.E.2    Felzmann, S.3    Vass, W.C.4    Xu, G.5    Whits, R.6    Lowy, D.R.7
  • 15
    • 0029128979 scopus 로고
    • Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes
    • Kim, H., T. Rosenbaum, M. A. Marchionni, N. Ratner, and J. E. DeClue, 1995 Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes. Oncogene 11:325-335.
    • (1995) Oncogene , vol.11 , pp. 325-335
    • Kim, H.1    Rosenbaum, T.2    Marchionni, M.A.3    Ratner, N.4    DeClue, J.E.5
  • 16
  • 17
    • 0025193871 scopus 로고
    • Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
    • Krengel, U., L. Schlichting, A. Scherer, R. Schumann, M. Frech, J. John, W. Kabsch, E. F. Pai, and A. Wittinghofer. 1990. Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell 62:539-548.
    • (1990) Cell , vol.62 , pp. 539-548
    • Krengel, U.1    Schlichting, L.2    Scherer, A.3    Schumann, R.4    Frech, M.5    John, J.6    Kabsch, W.7    Pai, E.F.8    Wittinghofer, A.9
  • 19
    • 85035164320 scopus 로고    scopus 로고
    • Unpublished results
    • Lin, B., and F. Tamanoi. Unpublished results
    • Lin, B.1    Tamanoi, F.2
  • 22
    • 0028923318 scopus 로고
    • Mutant farnesyltransferase β subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyl-transferase type I β subunit
    • Mitsuzawa, H., K. Esson, and F. Tamanoi. 1995 Mutant farnesyltransferase β subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyl-transferase type I β subunit. Proc Natl Acad Sci. USA 92:1704-1708
    • (1995) Proc Natl Acad Sci. USA , vol.92 , pp. 1704-1708
    • Mitsuzawa, H.1    Esson, K.2    Tamanoi, F.3
  • 24
    • 0027183207 scopus 로고
    • Suppression of oncogenic Ras by mutant neurofibromatosis type L genes with single amino acid substitutions
    • Nakafuku, M., M. Nagamine, A. Ohtoshi, K. Tanaka, A. Toh-e, and Y. Kaziro. 1993 Suppression of oncogenic Ras by mutant neurofibromatosis type L genes with single amino acid substitutions. Proc. Natl. Acad. Sci. USA 90:6706-6710
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6706-6710
    • Nakafuku, M.1    Nagamine, M.2    Ohtoshi, A.3    Tanaka, K.4    Toh-e, A.5    Kaziro, Y.6
  • 25
    • 0027491616 scopus 로고
    • The GTPase-activating NF1 fragment of 91 amino acids reverses v-Ha-Ras-induced malignant phenotype
    • Nur-E-Kamal, M. S., M. Varga, and H. Maruta. 1993 The GTPase-activating NF1 fragment of 91 amino acids reverses v-Ha-Ras-induced malignant phenotype. J. Biol. Chem. 268:22331-22337.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22331-22337
    • Nur-E-Kamal, M.S.1    Varga, M.2    Maruta, H.3
  • 27
    • 0029129675 scopus 로고
    • Use of the yeast two-hybrid system to evaluate Ras interactions with NF1-GAP
    • Poullet, P., and F. Tamanoi. 1995. Use of the yeast two-hybrid system to evaluate Ras interactions with NF1-GAP. Methods Enzymol. 255:488-497.
    • (1995) Methods Enzymol. , vol.255 , pp. 488-497
    • Poullet, P.1    Tamanoi, F.2
  • 28
    • 0026596419 scopus 로고
    • X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis
    • Prive, G. G., M. V. Milburn, L. Tong, A. M. de Vos, Z. Yamaizumi, S. Nishimura, and S. H. Kim. 1992. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proc. Natl Acad. Sci. USA 89:3649-3653.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 3649-3653
    • Prive, G.G.1    Milburn, M.V.2    Tong, L.3    De Vos, A.M.4    Yamaizumi, Z.5    Nishimura, S.6    Kim, S.H.7
  • 29
    • 0028359659 scopus 로고
    • Characterization of inherited and sporadic mutations in neurofibromatosis type-1
    • Purandare, S. M., M. G. Lanyon, and J. M. Conner. 1994. Characterization of inherited and sporadic mutations in neurofibromatosis type-1. Hum. Mol. Genet. 3:1109-1115.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 1109-1115
    • Purandare, S.M.1    Lanyon, M.G.2    Conner, J.M.3
  • 31
    • 0025777724 scopus 로고
    • A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21ras stimulation and promotes guanine nucleotide exchange
    • Rubinfeld, B., G. Wong, E. Bekesi, A. Wood, E. Heimer, F. McCormick, and P. Polakis. 1991. A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21ras stimulation and promotes guanine nucleotide exchange. Int. J. Peptide Protein Res. 38:47-53.
    • (1991) Int. J. Peptide Protein Res. , vol.38 , pp. 47-53
    • Rubinfeld, B.1    Wong, G.2    Bekesi, E.3    Wood, A.4    Heimer, E.5    McCormick, F.6    Polakis, P.7
  • 32
    • 0026327498 scopus 로고
    • Use of the Glu-Glu-Phe C-terminal epitope for rapid purification of the catalytic domain of normal and mutant ras GTPase-activating proteins
    • Skinner, R. H., S. Bradley, A. L. Brown, N. J. E. Johnson, S. Rhodes, D. K. Stammers, and P. N. Lowe. 1991. Use of the Glu-Glu-Phe C-terminal epitope for rapid purification of the catalytic domain of normal and mutant ras GTPase-activating proteins. J Biol Chem 266:14163-14166.
    • (1991) J Biol Chem , vol.266 , pp. 14163-14166
    • Skinner, R.H.1    Bradley, S.2    Brown, A.L.3    Johnson, N.J.E.4    Rhodes, S.5    Stammers, D.K.6    Lowe, P.N.7
  • 33
    • 0023806075 scopus 로고
    • Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
    • Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:331-340.
    • (1988) Gene , vol.67 , pp. 331-340
    • Smith, D.B.1    Johnson, K.S.2
  • 35
    • 0026516681 scopus 로고
    • A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity
    • Tanaka, K., D. R. Wood, B. K. Lin, M. Khalil, F. Tamanoi, and J. F. Cannon. 1992. A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity. Mol. Cell. Biol. 12:631-637.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 631-637
    • Tanaka, K.1    Wood, D.R.2    Lin, B.K.3    Khalil, M.4    Tamanoi, F.5    Cannon, J.F.6
  • 37
    • 85035160351 scopus 로고    scopus 로고
    • Personal communication
    • Upadhaya, M. Personal communication.
    • Upadhaya, M.1
  • 38
    • 0029120950 scopus 로고
    • Loss of neurofibromin results in neurotropin-independent survival of embryonic sensory and sympathetic neurons
    • Vogel, K. S., C. I. Brannan, N. A. Jenkins, N. G. Copeland, and L. F. Parada. 1995. Loss of neurofibromin results in neurotropin-independent survival of embryonic sensory and sympathetic neurons. Cell 82:733-742.
    • (1995) Cell , vol.82 , pp. 733-742
    • Vogel, K.S.1    Brannan, C.I.2    Jenkins, N.A.3    Copeland, N.G.4    Parada, L.F.5
  • 39
    • 0026176356 scopus 로고
    • sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1
    • Wang, Y., M. Boguski, M. Riggs, L. Rodgers, and M. Wigler. 1991. sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell. Regul 2:453-465
    • (1991) Cell. Regul , vol.2 , pp. 453-465
    • Wang, Y.1    Boguski, M.2    Riggs, M.3    Rodgers, L.4    Wigler, M.5
  • 40
    • 0027383386 scopus 로고
    • New activated RAS2 mutations identified in Saccharomyces cerevisiae
    • Wilson, B. A., M. Khalil, F. Tamanoi, and J. C. Cannon. 1993. New activated RAS2 mutations identified in Saccharomyces cerevisiae Oncogene 8:3441-3445.
    • (1993) Oncogene , vol.8 , pp. 3441-3445
    • Wilson, B.A.1    Khalil, M.2    Tamanoi, F.3    Cannon, J.C.4
  • 41
    • 0027938533 scopus 로고
    • Biochemical characterization of yeast RAS2 mutants reveals a new region of ras protein involved in the interaction with GTPase-activating proteins
    • Wood, D. R., P. Poullet, B, A. Wilson, M. Khalil, K. Tanaka, J. F. Cannon, and F. Tamanoi. 1994 Biochemical characterization of yeast RAS2 mutants reveals a new region of ras protein involved in the interaction with GTPase-activating proteins. J. Biol. Chem. 269:5322-5327.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5322-5327
    • Wood, D.R.1    Poullet, P.2    Wilson, B.A.3    Khalil, M.4    Tanaka, K.5    Cannon, J.F.6    Tamanoi, F.7
  • 42
    • 0025244911 scopus 로고
    • The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S cerevisiae
    • Xu, G., B. K. Lin, K. Tanaka, D. Dunn, D. R. Wood, R. Gesteland, R. White, R. Weiss, and F. Tamanoi. 1990. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S cerevisiae Cell 63:835-841.
    • (1990) Cell , vol.63 , pp. 835-841
    • Xu, G.1    Lin, B.K.2    Tanaka, K.3    Dunn, D.4    Wood, D.R.5    Gesteland, R.6    White, R.7    Weiss, R.8    Tamanoi, F.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.