The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro

British Journal of Cancer

Volumn 87, Issue 3, 2002, Pages 366-371

  Riebeling, C ^a,b   Forsea, A M ^a   Raisova, M ^a   Orfanos, C ^a   Geilen, C C ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Apoptosis; Bisphosphonates; Melanoma; Pamidronate; Rho proteins

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENOID; PAMIDRONIC ACID; PROTEIN P53;

APOPTOSIS; ARTICLE; DRUG EFFECT; GENE MUTATION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELANOMA CELL; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN FAMILY; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL DIVISION; DIPHOSPHONATES; DITERPENES; ENZYME ACTIVATION; GENES, P53; HUMANS; MELANOMA; MUTATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0037194354     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600476     Document Type: Article

References (31)

1. In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates
2. Rho signals to cell growth and apoptosis
3. Cell-mediated cytotoxicity for bladder carcinoma: Evaluation of a workshop
4. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase
5. Tumor production in the nude mouse, fibrinolytic activity and cross- reactivity with antimelanoma sera of various human tumor cell lines
6. Cell surface antigens of human malignant melanoma: Mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells
7. Genomic analysis of metastasis reveals an essential role for RhoC
8. Reduction in new metastases in breast cancer with adjuvant clodronate treatment
9. Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro
10. Rho GTPases are over-expressed in human tumors
11. In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors
12. Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system
13. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
14. Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Bisphosphonate treatment inhibits the growth of prostate cancer cells
17. Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals
18. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
19. Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release
20. The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis
21. Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
22. Cellular and molecular mechanisms of action of bisphosphonates
23. Bisphosphonates induce apoptosis in human breast cancer cell lines
24. The chemoresistance of human malignant melanoma: An update
25. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway
26. Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity
27. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
28. The effects of nitrogen-containing bisphosphonates on human epithelial (Caco-2) cells, an in vitro model for intestinal epithelium
29. Farnesyl pyrophosphate synthase is the molecular target of nitrogen- containing bisphosphonates
30. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine
31. Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat