Genetic analysis of β1 integrin function: Confirmed, new and revised roles for a crucial family of cell adhesion molecules

Journal of Cell Science

Volumn 110, Issue 23, 1997, Pages 2895-2904

  Brakebusch, Cord ^a,b   Hirsch, Emilio ^a,d   Potocnik, Alexandre ^c   Fässler, Reinhard ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b LUND UNIVERSITY   (Sweden)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

Differentiation; Homologous recombination; Morphogenesis; 1 integrin

Indexed keywords

CELL ADHESION MOLECULE; INTEGRIN; SCLEROPROTEIN;

CARCINOGENESIS; CELL DIFFERENTIATION; CYTOSKELETON; EXTRACELLULAR MATRIX; GENETIC ANALYSIS; HEMATOPOIESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031440110     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (14)

1. Adams, J. C. and Watt, F. M. (1993). Regulation of development and differentiation by the extracellular matrix. Development 117, 1183-1198.
2. Akiyama, S. K., Yamada, S. S., Chen, W. T. and Yamada, K. (1989). Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly and cytoskeletal organization. J. Cell Biol. 109, 863-875.
3. Almeida, E. A., Huovila, A. P., Sutherland, A. E., Stephens, L. E., Calarco, P. G., Shaw, L. M., Mercurio, A. M., Sonnenberg, A., Primakoff, P., Myles, D. G. and White, J. M. (1995). Mouse egg integrin α6β1 functions as a sperm receptor. Cell 81, 1095-1104.
4. Alon, R., Kassner, P. D., Carr, M. W., Finger, E. B., Hemler, M. E. and Springer, T. A. (1995). The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. Cell Biol. 128, 1243-1253.
5. Arroyo, A. G., Yang, J. T., Rayburn, H. and Hynes, R. O. (1996). Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell 85, 997-1008.
6. Bagutti, C., Wobus, A. M., Fässler, R. and Watt, F. M. (1996). Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and β1 integrin-deficient cells. Dev. Biol. 179, 184-196.
7. Belkin, A. M., Zhidkova, N. I., Balzac, F., Altruda, F., Tomatis, D., Maier, A., Tarone, G., Koteliansky, V. E. and Burridge, K. (1996). β1D integrin displaces the β1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells. J. Cell Biol. 132, 211-226.
8. Berlin, C., Bargatze, R. F., Campbell, J. J., von Andrian, U. H., Szabo, M. C., Hasslen, S. R., Nelson, R. D., Berg, E. L., Erlandsen, S. L. and Butcher, E. C. (1995). α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80, 413-422.
9. Bloch, W., Forsberg, E., Lentini, S., Brakebusch, C. Martin, K., Krell, H. W., Weidle, U. H., Addicks, K. and Fässler, R. (1997). β1 integrin is essential for teratoma growth and angiogenesis. J. Cell Biol. 139, 265-278.
10. Boudreau, N., Sympson, C. J., Werb, Z. and Bissell, M. J. (1995). Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893.
11. Brooks, P. C., Montgomery, A. M., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G. and Cheresh, D. A. (1994a). Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
12. Brooks, P. C., Clark, R. A. and Cheresh, D. A. (1994b). Requirement of vascular integrin αvβ3 for angiogenesis. Science 264, 569-571.
13. Zhidkova, N. I., Belkin, A. M. and Mayne, R. (1995). Novel isoform of β1 integrin expressed in skeletal and cardiac muscle. Biochem. Biophys. Res. Commun. 214, 279-285.
14. Zutter, M. M., Santoro, S. A., Staatz, W. D. and Tsung, Y. L. (1995). Re-expression of the α2β1 integrin abrogates the malignant phenotype of breast carcinoma cells. Proc. Nat. Acad. Sci. USA 92, 7411-7415.