Comparative study and identification of potent eukaryotic transcriptional repressors in gene switch systems

Journal of Biotechnology

Volumn 97, Issue 3, 2002, Pages 275-285

  Imhof, Markus O ^a   Chatellard, Philippe ^a   Mermod, Nicolas ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Gene switch; Regulation; Repression; Transcription

Indexed keywords

CELLS; GENES; PROTEINS;

GENE THERAPY;

BIOTECHNOLOGY;

REPRESSOR PROTEIN;

ARTICLE; CELL SPECIFICITY; CHIMERA; COMPARATIVE STUDY; EUKARYOTE; GENE SILENCING; GENE SWITCHING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; TRANSCRIPTION REGULATION;

CELL LINE; DNA, BACTERIAL; EUKARYOTIC CELLS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; HUMANS; MODELS, GENETIC; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EUKARYOTA; MAMMALIA;

EID: 0037190109     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(02)00104-9     Document Type: Article

References (51)

1. Chimeric receptors as gene switches
2. Histone deacetylases: Transcriptional repression with SINers and NuRDs
3. Mad proteins contain a dominant transcription repression domain
4. Interaction of the human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone
5. The τ4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing
6. Methylation-induced repression-belts, braces, and chromatin
7. Mutational analysis of the transcription activation domain of RelA: Identification of a highly synergistic minimal acidic activation module
8. Tet B or not tet B: Advances in tetracycline-inducible gene expression
9. Radical mutations reveal TATA-box binding protein surfaces required for activated transcription in vivo
10. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
11. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1
12. Structure and specificity of nuclear receptor-coactivator interactions
13. Tetracycline-reversible silencing of eukaryotic promoters
14. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily
15. Mechanism of synergy between TATA and initiator: Synergistic binding of TFIID following a putative TFIIA-induced isomerization
16. The steroid and thyroid hormone receptor superfamily
17. The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
18. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells
19. Transcriptional repression in development
20. Transcriptional repression by the Drosophila even-skipped protein: Definition of a minimal repression domain
21. Active repression mechanisms of eukaryotic repressors
22. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
23. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
24. E-cadherin is a WT1 target gene
25. Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes
26. A regulatory network for the efficient control of transgene expression
27. Drosophila development: Delimiting patterns by repression
28. Quantitation of RNA polymerase II and its transcription factors in HeLa cell: Little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure
29. Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer
30. Histone deacetylase associated with the mSin3 corepressor mediate Mad transcriptional repression
31. Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction
32. Transcriptional repression mediated by the WT1 Wilms tumor gene product
33. Krüppel-associated boxes are potent transcriptional repression domains
34. Transcriptional repression by RING finger protein TIF1β that interacts with the KRAB repressor domain of KOX1
35. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
36. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
37. The groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
38. The WT1 Wilms' tumor suppressor gene: How much do we really know?
39. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing
40. The activities of acidic and glutamine-rich transcription activation domains in plant cells: Design of modular transcription factors for high-level expression
41. Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions
42. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes
43. SMRTER, a drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development
44. The transcriptional repressor even-skipped interacts directly with TATA-binding protein
45. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
46. The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression
47. Chromatin disruption and modification
48. Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase
49. Coactivator and corepressor complexes in nuclear receptor function
50. Functional dissection of a human Dr1-DRAP1 repressor complex
51. Development of stable cell lines for production or regulated expression using matrix attachment regions