Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle

Cancer Letters

Volumn 177, Issue 2, 2002, Pages 111-118

  Agami, Reuven ^a   Bernards, René ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Cell cycle; Checkpoint; Cyclin; Cyclin dependent kinases; DNA damage; G1; G2; Mitogen; Proteasome; Restriction point; Stress response

Indexed keywords

GROWTH FACTOR; MITOGENIC AGENT;

CARCINOGENESIS; CELL COMPOSITION; CELL CYCLE G1 PHASE; CELL DAMAGE; CELL PROLIFERATION; DNA DAMAGE; GENE MUTATION; MITOGENESIS; NUTRIENT; PRIORITY JOURNAL; SHORT SURVEY; STRESS;

EUKARYOTA;

EID: 0037187453     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00785-6     Document Type: Review

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33. Beta-catenin signaling and cancer
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39. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
40. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
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51. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
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53. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
54. pRB plays an essential role in cell cycle arrest induced by DNA damage
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56. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)