The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 93, Issue 4, 1999, Pages 429-432

  Fivelman, Quinton L ^a   Walden, Jason C ^a   Smith, Peter J ^a   Folb, Peter I ^a   Barnes, Karen I ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antagonism; Artemisinin; Artesunate; Chemotherapy; Chloroquine; Doxycycline; Drug combinations; Malaria; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinine; Synergy

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; CHLOROQUINE; DOXYCYCLINE; MEFLOQUINE; PYRIMETHAMINE; QUININE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG RESISTANCE; IN VITRO STUDY; PLASMODIUM FALCIPARUM;

EID: 0032837350     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(99)90147-5     Document Type: Article

References (17)

1. Barradell, L. B. & Fitton, A. (1995). Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs, 50, 714-741.
2. Chawira, A. N. & Warhurst, D. C. (1987). The effect of artemisinin combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro. Journal of Tropical Medicine and Hygiene, 90, 1-8.
3. Chawira, A. N., Warhurst, D. C. & Peters, W. (1986). Qinghaosu resistance in rodent malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 477-480.
4. Chawira, A. N., Warhurst, D. C., Robinson, B. L. & Peters, W. (1987). The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene, 81, 554-558.
5. Chevli, R. & Fitch, C. D. (1982). The antimalarial drug mefloquine binds to membrane phospholipids. Antimicrobial Agents and Chemotherapy, 21, 581-586.
6. Desjardins, R. E., Canfield, C. J., Haynes, J. D. & Chulay, J. D. (1979). Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy, 16, 710-718.
7. Ekong, R. & Warhurst, D. C. (1990). Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, 757-758.
8. 3H]-dihydroartemisinine in P. falciparum in vitro. Annals of Tropical Medicine and Parasitology, 79, 367-374.
9. Hong, Y. L., Yang, Y. Z. & Meshnick, S. R. (1994). The interaction of artemisinin with malarial hemozoin. Molecular and Biochemical Parasitology, 63, 121-128.
10. Makler, M. T., Ries, J. M., Williams, J. A., Bancroft, J. E., Piper, R. C., Gibbins, B.L. & Hinrichs, D.J. (1993). Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. American Journal of Tropical Medicine and Hygiene, 48, 739-741.
11. Meshnick, S. R., Thomas, A., Ranz, A., Xu, C. M. & Pan, H. Z. (1991). Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Molecular and Biochemical Parasitology, 49, 181-190.
12. Paitayatat, S., Tarnchompoo, B., Thebtaranonth, Y. & Yuthavong, Y. (1997). Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. Journal of Medicinal Chemistry, 40, 633-638.
13. Peters, W., Howells, R. E., Portus, J., Robinson, B. L., Thomas, S. & Warhurst, D. C. (1977). The chemotherapy of rodent malaria, XXVII. Studies on mefloquine (WR 142,490). Annals of Tropical Medicine and Parasitology, 71, 407-418.
14. Slater, A. F. & Cerami, A. (1992). Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Nature, 355, 167-169.
15. Stahel, E., Druilhe, P. & Gentilini, M. (1988). Antagonism of chloroquine with other antimalarials. Transactions of the Royal Society of Tropical Medicine and Hygiene, 82, 221.
16. Trager, W. & Jensen, J. B. (1976). Human malaria parasites in continuous culture. Science, 193, 673-675.
17. White, N. J. (1998). Preventing antimalarial drug resistance through combinations. Drug Resistance Updates, 1, 3-9.