Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat

Neuroscience

Volumn 109, Issue 2, 2002, Pages 219-230

  McCullers, D L ^a,b   Sullivan, P G ^a   Scheff, S W ^a   Herman, J P ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

bax; bcl 2; Cortical impact; Glucocorticoid receptor; Mineralocorticoid receptor; Spironolactone

Indexed keywords

GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SPIRONOLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN LEVEL; BRAIN REGION; CELL LOSS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DENTATE GYRUS; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECEPTOR BLOCKING; TRANSCRIPTION REGULATION;

ALDOSTERONE ANTAGONISTS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN INJURIES; CELL SURVIVAL; GLUCOCORTICOIDS; HIPPOCAMPUS; HORMONE ANTAGONISTS; MALE; MIFEPRISTONE; MINERALOCORTICOIDS; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER; SPIRONOLACTONE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037185555     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00477-8     Document Type: Article

References (88)

1. Regulation of ischemic cell death by glucocorticoids and adrenocorticotropic hormone
2. Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization
3. The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response
4. Neuronal cell loss in the CA3 subfield of the hippocampus following cortical contusion utilizing the optical disector method for cell counting
5. Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro
6. Protection against oxidative stress-induced neuronal cell death - A novel role for RU486
7. The role of glucocorticoids in the treatment of severe head injury
8. Involvement of lipid peroxidation in CNS injury
9. RU486 (mifepristone): Mechanisms of action and clinical uses
10. Inhibition of oxidative modification of proteins by RU486
11. Excitotoxic cell death
12. Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats
13. Dexamethasone and severe head injury. A prospective double-blind study
14. Experimental fluid percussion brain injury: Vascular disruption and neuronal and glial alterations
15. Regional expression of Bcl-2 mRNA and mitochondrial cytochrome c release after experimental brain injury in the rat
16. Corticosterone enhances kainic acid-induced calcium elevation in cultured hippocampal neurons
17. Corticosterone impairs hippocampal neuronal calcium regulation
18. High dose glucocorticoids in the management of severe head injury
19. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
20. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons
21. Lateral cortical impact injury in rats: Pathologic effects of varying cortical compression and impact velocity
22. Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites
23. Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury
24. Neurotransmitter-mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids
25. Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system
26. Localization and regulation of glucocorticoid and mineralocorticoid
27. Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo
28. Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus
29. Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat
30. Glucocorticoids inhibit glucose transport in cultured hippocampal neurons and glia
31. Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus
32. Corticosteroids in the brain. Cellular and molecular actions
33. Mechanisms of calpain proteolysis following traumatic brain injury: Implications for pathology and therapy: A review and update
34. Corticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons
35. Gene expression of progesterone receptor isoforms in the rat brain
36. Corticosteroid modulation of hippocampal potentials: Increased effect with aging
37. Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: Relevance to brain aging
38. Delayed neuronal death in the gerbil hippocampus following ischemia
39. Comparison of ibotenate and kainate neurotoxicity in rat brain: A histological study
40. Selective vulnerability of dentate hilar neurons following traumatic brain injury: A potential mechanistic link between head trauma and disorders of the hippocampus
41. Mineralocorticoid receptors regulate bcl-2 and p53 mRNA expression in hippocampus
42. Adrenocorticosteroid receptor blockade and excitotoxic challenge regulate adrenocorticosteroid receptor mRNA levels in hippocampus
43. Effects of adrenocorticosteroid receptor blockade and traumatic brain injury on hippocampal neuron viability
44. Adrenal steroid receptors and actions in the nervous system
45. Glucocorticoids may enhance oxygen radical-mediated neurotoxicity
46. Glucocorticoids increase the accumulation of reactive oxygen species and enhance adriamycin-induced toxicity in neuronal culture
47. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
48. Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization
49. Regulation of ischemic hippocampal damage in the gerbil: Adrenalectomy alters the rate of CA1 cell disappearance
50. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
51. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
52. Corticosteroid regulation of ion channel conductances and mRNA levels in individual hippocampal CA1 neurons
53. Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice
54. The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury
55. The two faces of a steroid antagonist: When an antagonist isn't
56. (S)-emopamil attenuates acute reduction in regional cerebral blood flow following experimental brain injury
57. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
58. Antioxidant: A new role for RU-486 and related compounds
59. Temporal profile of neuronal damage in a model of transient forebrain ischemia
60. BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice
61. On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation
62. Controversies surrounding glucocorticoid-mediated cell death in the hippocampus
63. Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
64. Type I and type II corticosteroid receptor gene expression in the rat: Effect of adrenalectomy and dexamethasone administration
65. Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: Functional implications
66. Gender differences in acute CNS trauma and stroke: Neuroprotective effects of estrogen and progesterone
67. A mechanism for glucocorticoid toxicity in the hippocampus: Increased neuronal vulnerability to metabolic insults
68. Glucocorticoid toxicity in the hippocampus. Temporal aspects of synergy with kainic acid
69. Glucocorticoid toxicity in the hippocampus: Reversal by supplementation with brain fuels
70. Glucocorticoid toxicity in the hippocampus: In vitro demonstration
71. Glucocorticoids potentiate ischemic injury to neurons: Therapeutic implications
72. Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents
73. Selective vulnerability of the hippocampus in brain ischemia
74. In situ hybridization approaches to the study of the nervous system
75. Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: Localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity
76. Persistent memory dysfunction is associated with bilateral hippocampal damage following experimental brain injury
77. Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures
78. Chemical adrenalectomy reduces hippocampal damage induced by kainic acid
79. Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus
80. Physiological elevations of glucocorticoids potentiate glutamate accumulation in the hippocampus
81. Traumatic brain injury alters synaptic homeostasis: Implications for impaired mitochondrial and transport function
82. Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
83. Regulation of ionotropic glutamate receptors following subchronic and chronic treatment with typical and atypical antipsychotics
84. Effect of dexamethasone on cerebral edema from cranial impact in the cat
85. Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS
86. Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema
87. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
88. Role of calcium in central nervous system injuries