Activated eosinophils are the major source of Th2-associated cytokines in the schistosome granuloma

Journal of Immunology

Volumn 162, Issue 2, 1999, Pages 1003-1009

  Rumbley, Catherine A ^b   Sugaya, Hiroko ^a,b   Zekavat, S Ali ^b   El Refaei, Mohamed ^b   Perrin, Peter J ^b   Phillips, S Michael ^b  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOKINE PRODUCTION; EOSINOPHILIA; FEMALE; GRANULOMA; HELPER CELL; HOST RESISTANCE; INFECTION RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA; SCHISTOSOMIASIS; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL SEPARATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILIC GRANULOMA; EOSINOPHILS; FEMALE; FLOW CYTOMETRY; IN SITU HYBRIDIZATION; INTRACELLULAR FLUID; MICE; MICE, INBRED C57BL; RNA, MESSENGER; SCHISTOSOMIASIS MANSONI; SPLENIC DISEASES; TH2 CELLS;

EID: 0033555962     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. World Health Organization. 1993. The Control of Schistosomiasis. Technical Report Series No. 830. World Health Organization. Geneva.
2. Mott, K. E. 1989. Contrasts in the control of Schistosomiasis. Mem. Inst. Os. Cruz. 84:3.
3. Warren, K. S., E. O. Domingo, and R. B. T. Cowan. 1967. Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. Am. J. Pathol. 51:735.
4. Phillips, S. M., and P. J. Lammie. 1986. Immunopathology of granuloma formation and fibrosis in Schistosomiasis. Parasitol. Today 2:296.
5. Mahmoud, A. A. F. 1984. Trematode infections: Schistosomiasis. In Tropical and Geographical Medicine. K. S. Warren, and A. A. F. Mahmoud, eds. McGraw-Hill, New York, p. 443.
6. Mathew, R. C, and D. L. Boros. 1986. Anti-L3T4 antibody treatment suppresses hepatic granuloma formation and abrogates antigen-induced interleukin-2 production in Schistosoma mansoni infection. Infect. Immun. 54:820.
7. Phillips, S. M., G. P. Linette, B. L. Doughty, J. E. Byram, and F. von Lichtenberg. 1987. In vivo T cell depletion regulates resistance and morbidity in murine Schistosomiasis. J. Immunol. 139:919.
8. Phillips, S. M., J. J. DiConza, J. A. Gold, and W. A. Reid. 1977. Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependency of eosinophilia, granuloma formation, and host morbidity. J. Immunol. 118:594.
9. Pearce, E. J., J. P. Vasconcelos, L. R. Brunet, and E. A. Sabin. 1996. IL-4 in schistosomiasis. Exp. Parasitol. 84:295.
10. Pearce, E. J., P. Caspar, J. M. Grzych, F. A. Lewis, and A. Sher. 1991. Down-regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth. Schistosoma mansoni. J. Exp. Med. 173:159.
11. Wynn, T. A., and A. W. Cheever. 1995. Cytokine regulation of granuloma formation in schistosomiasis. Curr. Opin. Immunol. 7:505.
12. Weller, P. F. 1994. Eosinophils: structure and functions. Curr. Opin. Immunol. 6:85.
13. Bruce, J. L., and M. G. Radke. 1971. I. Cultivation of Biomphalaria glabrata and maintenance of S. mansoni in the laboratory. In Culturing Biomphalaria glabrata and Oncomelania (Gastropoda) for Large Scale Studies of Schistosomiasis. Biomedical Department, 406th Medical Laboratory, San Francisco, p. 1.
14. Rumbley, C. A., S. A. Zekavat, H. Sugaya, P. J. Perrin, M. A. Ramadan, and S. M. Phillips. 1999. The schistosome granuloma: characterization of lymphocyte migration, activation, and cytokine production. J. Immunol. 161:4129.
15. Klinman, D., and T. Nutnam. 1995. ELISPOT assay to detect cytokine-secreting murine and human cells. In Current Protocols in Immunology. A. K. J. Coligan, D. Margulies, E. Shevach, and W. Strober, eds. John Wiley & Sons, New York, Unit 6.19. pp. 1-8.
16. Hua, X., H. Sugaya, and K. Yoshimura. 1990. Alteration in density of eosinophils in the cerebrospinal fluid of mice infected with Angiostrongylus cantonensis. Int. J. Parasitol. 20:681.
17. Gartner, I. 1980. Separation of human eosinophils in density gradients of polyvinylpyrrolidone-coated silica gel (Percoll). Immunology 40:133.
18. Bentley, A. G., S. M. Phillips, R. J. Kaner, V. J. Theodorides, G. P. Linette, and B. L. Doughty. 1985. In vitro delayed hypersensitivity granuloma formation: development of an antigen-coated bead model. J. Immunol. 134:4163.
19. Brattig, N. W., C. E. Medina-De la Garza, and F. W. Tischendorf. 1993. Improved Randolph stain for direct leukocyte differentiation and determination of total eosinophil count in a hemacytometer. Biotechnol. Histochem. 68:255.
20. Konwalinka, G., P. Glasser, R. Odavic, E. Bogusch, F. Schmalzl, and H. Braunsteiner. 1980. A new approach to the morphological and cytochemical evaluation of human bone marrow CFUC in agar cultures. Exp. Hematol. 8:434.
21. Miyasato, M., S. Tsuda, N. Kitamura, K. Shirouzu, T. Nakama, and Y. Sasai. 1995. Purification of human blood eosinophils by a combination method using anti-CD16 monoclonal antibody, immunobeads, and Nycodenz density gradient. J. Dermaiol. Sci. 10:118.
22. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Gause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430.
23. Ragheb, S., and D. L. Boros. 1989. Characterization of granuloma T lymphocyte function from Schistosoma mansoni-infected mice. J. Immunol. 142:3239.
24. Boros, D. L. 1994. The role of cytokines in the formation of the schistosome egg granuloma. Immunobiology. 191:441.
25. Cheever, A. W., Y. Xu. J. G. Macedonia, T. Cox, S. Hieny, and A. Sher. 1992. The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice. Mem. Inst. Os. Cruz. 87(Suppl. 4):81.
26. Henderson, G. S., X. Lu, T. L. McCurley, and D. G. Colley. 1992. In vivo molecular analysis of lymphokines involved in the murine immune response during Schisiosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-γ mRNA. and IL-2 mRNA levels in the granulomatous livers, mesenteric lymph nodes, and spleens during the course of modulation. J. Immunol. 148:2261.
27. Xu, Y. H., J. Macedonia, A. Sher, E. Pearce, and A. W. Cheever. 1991. Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum. Infect, Immun. 59:2934.
28. Sabin, E. A., M. I. Araujo, E. M. Carvalho, and E. J. Pearce. 1996. Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni. J. Infect. Dis. 173:269.
29. Rothenberg, M. E., R. Ownhey, P. D. Mehlhop, P. M. Loiselle, M, van de Rijn, J. V. Bonventre, H. C. Oettgen, P. Leder, and A. D. Luster. 1996. Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Mol. Med. 2:334.
30. de Andres, B., E. Rakasz, M. Hagen, M. L. McCormik, A. L. Mueller, D. Elliot, A. Metwali, M. Sandor, B. E. Britigan, J. V. Weinstock, et al. 1997. Lack of Fc-epsilon receptors on murine eosinophils: implications for the functional significance of elevated IgE and eosinophils in parasitic infections. Blood 89:3826.
31. de Andres, B., A. L. Mueller, A. Blum, J. Weinstock, S. Verbeek, M. Sandor, and R. G. Lynch. 1997. FcγRII (CD32) is linked to apoptotic pathways in murine granulocyte precursors and mature eosinophils. Blood 90:1267.
32. Butterworth, A. E., M. A. Vadas, D. L. Wassom, A. Dessein, M. Hogan, B. Sherry, G. J. Gleich, and J. R. David. 1979. Interactions between human eosinophils and schistosomula of Schistosoma mansoni. II. The mechanism of irreversible eosinophil adherence. J. Exp. Med. 150:1456.
33. Capron, M., G. Torpier, and A. Capron. 1979. In vitro killing of S. mansoni schistosomula by eosinophils from infected rats: role of cytophilic antibodies. J. Immunol 123:2220.
34. James, S. L., and D. G. Colley. 1978. Eosinophil-mediated destruction of Schistosoma mansoni eggs. III. Lymphokine involvement in the induction of eosinophil functional abilities. Cell. Immunol. 38:48.
35. James, S. L., and D. G. Colley. 1976 Eosinophil-mediated destruction of Schistosoma mansoni eggs. J. Reticulo. Sec. 20:359.
36. DiPiro, J. T. 1997. Cytokine networks with infection: mycobacterial infections, leishmaniasis. human immunodeficiency virus infection and sepsis. Pharmacotherapy 17:205.
37. Golding, B., M. Zaitseva, and H. Golding. 1994. The potential for recruiting immune responses toward type 1 or type 2 T cell help. Am. J. Trop. Med. Hyg. 50(Suppl. 4):33.
38. Qin, L., Y. Ding, and J. S. Bromberg. 1996. Gene transfer of transforming growth factor-β1 prolongs murine cardiac allograft survival by inhibiting cell-mediated immunity. Hum. Gene Ther. 7:1981.
39. Sher, A., R. L. Coffman, S. Hieny, and A. W. Cheever. 1990. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. 145:3911.