Implications of active site constraints on varied DNA polymerase selectivity

Journal of the American Chemical Society

Volumn 124, Issue 38, 2002, Pages 11230-11231

  Strerath, Michael ^a   Cramer, Janina ^b   Restle, Tobias ^b   Marx, Andreas ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE;

ARTICLE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; GENE INSERTION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE; STEREOCHEMISTRY;

BINDING SITES; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE;

EID: 0037174355     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja027060k     Document Type: Article

References (25)

1. (a) Echols, H.; Goodman, M. F. Annu. Rev. Biochem. 1991, 60, 477-511.
2. (b) Goodman, M. F. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 10493-10495.
3. (c) Kunkel, T. A.; Bebenek, K. Annu. Rev. Biochem. 2000, 69, 497-529.
4. (d) Kool, E. T.; Morales, J. C.; Guckian, K. M. Angew. Chem., Int. Ed. 2000, 39, 990-1009.
5. (e) Patel, P. H.; Loeb, L. A. Nat. Struct. Biol. 2001, 8, 656-659.
6. (f) Kool, E. T. Annu. Rev. Biochem. 2002, 71, 191-219.
7. Morales, J. C.; Kool, E. T. J. Am. Chem. Soc. 2000, 122, 1001-1007.
8. Matsuda, T.; Bebenek, K.; Masutani, C.; Hanaoka, F.; Kunkel, T. A. Nature 2000, 404, 1011-1013.
9. (a) Goodman, M. F.; Tippin, B. Nat. Rev. Mol. Cell Biol. 2000, 1, 101-109.
10. (b) Friedberg, E. C.; Fischhaber, P. L.; Kisker, C. Cell 2001, 107, 9-12.
11. (c) Marx, A.; Summerer, D. ChemBioChem 2002, 3, 405-407.
12. Summerer, D.; Marx, A. Angew. Chem., Int. Ed. 2001, 40, 3693-3695.
13. (a) Preston, B. D.; Poisez, B. J.; Loeb, L. A. Science 1988, 242, 1168-1171.
14. (b) Roberts, J. D.; Bebenek, K.; Kunkel, T. A. Science 1988, 242, 1171-1173.
15. (c) Bebenek, K.; Abbotts, J.; Roberts, J. D.; Wilson, S. H.; Kunkel, T. A. J. Biol. Chem. 1989, 264, 16948-16956.
16. (d) Bebenek, K.; Abbotts, J.; Wilson, S. H.; Kunkel, T. A. J. Biol. Chem. 1993, 268, 10324-10334.
17. (a) Huang, H. F.; Chopra, R.; Verdine, G. L.; Harrison, S. C. Science 1998, 282, 1669-1675.
18. (b) Sarafianos. S. G.; Das, K.; Clark, A. D., Jr.; Ding, J.; Boyer, P. L.; Hughes, S. H.; Arnold, E. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 10027-10032.
19. (c) Gao, H.-Q.; Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H. J. Mol. Biol. 2000, 300, 403-418.
20. (a) Wainberg, M. A.; Drosopoulos, W. C.; Salomon, H.; Hsu, M.; Borkow, G.; Parniak, M.; Gu, Z.; Song, Q.; Manne, J.; Islam, S.; Castriota, G.; Prasad, V. R. Science 1996, 271, 1282-1285.
21. (b) Pandey, V. R.; Kaushik, N.; Rege, N.; Sarafianos, S. G.; Yadav, P. N. S.; Modak, M. J. Biochemistry 1996, 35, 2168-2179.
22. (c) Feng, J. Y.; Anderson, K. S. Biochemistry 1999, 38, 9440-9448.
23. Complete sequences of DNA substrates, experimental conditions, and full data of quantitative DNA polymerase assays are provided in the Supporting Information.
24. (a) Creighton, S.; Bloom, L. B.; Goodman, M. F. Methods Enzymol. 1995, 262, 232-256.
25. (b) Fygenson, D. K.; Goodman, M. F. J. Biol. Chem. 1997, 272, 27931-27935.