Hedgehog signalling: Pulling apart Patched and Smoothened

Current Biology

Volumn 12, Issue 12, 2002, Pages

  Stark, David R ^a  

^a ELSEVIER MASSON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERINACEIDAE;

CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; HEDGEHOG PROTEIN, DROSOPHILA; INSECT PROTEIN; MEMBRANE PROTEIN; PTC PROTEIN, DROSOPHILA; SMOOTHENED PROTEIN, DROSOPHILA;

ANIMAL; ARTICLE; DROSOPHILA; FORECASTING; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; FORECASTING; INSECT PROTEINS; MEMBRANE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 0037173069     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00920-X     Document Type: Review

References (17)

1. Hedgehog signaling in animal development: Paradigms and principles
2. Transducing Hedgehog: The story so far
3. Sonic hedgehog induces the segregation of Patched and Smoothened in endosomes
4. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
5. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation
6. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
7. Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system
8. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
9. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
10. The sterol-sensing domain: Multiple families, a unique role?
11. Teratogen-mediated inhibition of target tissue response to Shh signaling
12. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport
13. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
14. Activating Smoothened mutations in sporadic basal-cell carcinoma
15. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
16. Smoothened activates Gαi-mediated signaling in frog melanophores
17. Transmembrane molecular pump activity of Niemann-Pick C1 protein