Aerosol beclomethasone dipropionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma

Journal of Allergy and Clinical Immunology

Volumn 101, Issue 1, 1998, Pages 14-23

  Reed, Charles E ^a   Offord, Kenneth P ^b   Nelson, Harold S ^b   Li, James T ^b   Tinkelman, David G ^b  

^a Department of Allergy Research ^*  (United States)

^b MAYO CLINIC   (United States)

Author keywords

Asthma; Beclomethasone; Theophylline

Indexed keywords

BECLOMETASONE; THEOPHYLLINE;

ADOLESCENT; ADULT; AEROSOL; AGED; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EOSINOPHILIA; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INSOMNIA; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NERVOUSNESS; ORAL DRUG ADMINISTRATION; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; SUSTAINED RELEASE PREPARATION; VERTIGO;

EID: 6844265571     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70187-3     Document Type: Article

References (27)

1. Dunnill MS. The pathology of asthma with special reference to changes in the bronchial mucosa. J Clin Pathol 1960;13:27-33.
2. Kay AB. Pathology of mild, severe, and fatal asthma. Am J Respir Crit Care Med 1996;154:S66-9.
3. Reed CE. New therapeutic approaches in asthma. J Allergy Clin Immunol 1986;77:537-43.
4. Expert panel report on guidelines for diagnosis and management of asthma II. Bethesda (MD): National Heart and Blood Institute Information Center; 1997.
5. Dutoit JI, Salome CM, Woolcock AJ. Inhaled corticosteroids reduce the severity of bronchial hyperresponsiveness in asthma but oral theophylline does not. Am Rev Respir Dis 1987;136:1174-8.
6. Kamada AK, Szefler SJ, Martin RJ, Boushey HA, Chinchilli VM, Drazen JM, et al. Issues in the use of inhaled glucocorticoids. Am J Respir Crit Care Med 1996;153:1739-48.
7. Toogood JH, Jennings B, Greenway RW, Chuang L. Candidiasis and dysphonia complicating beclomethasone treatment of asthma. J Allergy Clin Immunol 1980;65:143-53.
8. ATS statement. Standardization of spirometry, 1987 update. Am Rev Respir Dis 1987;136:1283-98.
9. Crapo RO, Morris AH, Gardner RM. Reference spirometric values for spirometry using techniques and equipment that meets ATS and recommendations. Am Rev Respir Dis 1981;123:639-64.
10. Polgar G, Promadhat V. Pulmonary function testing in children: techniques and standards. Philadelphia: WB Saunders; 1971.
11. Knudson RJ, Slatin RC, Lebowitz MD, Burrows B. The maximum expiratory flow-volume curve. Normal standards, variability, and effects of age. Am Rev Respir Dis 1976;113:587-600.
12. Hsu KHK, Jenkins DE, Hsi BP, Bourhofer E, Thompson V, Tanakawa N, et al. Ventilatory functions of normal children and young adults. J Pediatr 1979;95:14-23.
13. Chai H, Farr RS, Froehlich LA, Mathison DA, Mclean JA, Rosenthal RR, et al. Standardization of bronchial inhalation procedures. J Allergy Clin Immunol 1975;56:323-6.
14. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-48.
15. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
16. Galant SP, Lawrence M, Meltzer EO, Tomasko M, Baker KA, Kellerman DJ. Fluticasone propionate compared with theophylline for mild-to-moderate asthma. Ann Allergy Asthma Immunol 1996;77:112-8.
17. Toogood JH, Jennings B, Baskerville J, Lefcoe N, Newhouse M. Assessment of a device for reducing oropharyngeal complications during beclomethasone treatment of asthma. Am Rev Respir Dis 1981;123(Suppl):113-4.
18. Toogood JH, Baskerville J, Jennings B, Lefcoe NM, Johansson S. Use of spacers to facilitate inhaled corticosteroid treatment of asthma. Am Rev Respir Dis 1984;129:723-9.
19. Salzman GA, Pyszczynski DR. Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol 1988;81:424-8.
20. Ward AJM, McKenniff M, Evans JM, Page CP, Costello JF. Theophylline - an immunomodulatory role in asthma? Am Rev Respir Dis 1993;147:518-23.
21. Kidney J, Dominguez M, Taylor PM, Rose M, Chung KF, Barnes PJ. Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. Am J Respir Crit Care Med 1995;151:1907-14.
22. Crescioli S, Spinazzi A, Pozzani M, Mapp CE, Boschetto P, Fabbri LM, et al. Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects. Ann Allergy 1991;66:245-51.
23. Schudt C, Tenor H, Hatzelmann A. PDE isoenzymes as targets for anti-asthma drugs. Eur Respir J 1995;8:1179-83.
24. Sullivan P, Bekir S, Jaffer Z, Page C, Jeffery P, Costello J. Antiinflammatory effects of low-dose oral theophylline in atopic asthma. Lancet 1994;343:1006-8.
25. Barnes PJ. Theophylline: cyclic nucleotides and phosphodiesterases and airway function. Eur Respir J 1995;8:457-62.
26. Djukanovic R, Finnerty JP, Lee C, Wilson S, Madden J, Holgate ST. The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results. Eur Respir J 1995;8:831-3.
27. Tinkelman DG, Reed CE, Nelson HS, Offord KP. Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 1993;92:64-77.