Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 164, Issue 2, 2001, Pages 273-276

  Lim, Sam ^a,b   Tomita, Katsuyuki ^a,b   Carramori, Gaetano ^a,b   Jatakanon, Anon ^a,b   Oliver, Brian ^a,b   Keller, Andreas ^a,b   Adcock, Ian ^a,b   Chung, Kian Fan ^a,b   Barnes, Peter J ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ALTANA PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; STEROID; THEOPHYLLINE DERIVATIVE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CELL COUNT; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; EOSINOPHIL; EXPIRED AIR; FEMALE; FIBEROPTIC BRONCHOSCOPY; HUMAN; LUNG FUNCTION; MALE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; PROVOCATION TEST; SPUTUM ANALYSIS;

EID: 0035880183     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.164.2.2006043     Document Type: Article

References (24)

1. Exhaled nitric oxide: A new lung function test
2. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma
3. Effect of inhaled budesonide on lung function and airway inflammation: Assessment by various inflammatory markers in mild asthma
4. Airway eosinophilic inflammation, epithelial damage, and bronchial hyperresponsiveness in patients with mild-moderate, stable asthma
5. Regulation of Ig-induced eosinophil degranulation by adenosine 3′,5′-cyclic monophosphate
6. IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma
7. Theophylline suppresses the release of tumour necrosis factor-α by blood monocytes and alveolar macrophages
8. The effect of theophylline on T-lymphocyte activation in vitro
9. Human T-lymphocyte E-rosette formation. I. A process modulated by intracellular cAMP
10. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma
11. Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma
12. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma
13. Immunomodulation by theophylline in asthma: Demonstration by withdrawal of therapy
14. Exhaled and nasal nitric oxide measurements: Recommendations
15. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD
16. Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: A placebo-controlled parallel group study
17. Theophylline inhibits the release of eosinophil survival cytokines - Is Raf-1 the protein kinase A target?
18. The value of maintenance theophylline in steroid-dependent asthma
19. Efficacy of Uniphyl, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids
20. Comparison of patients' compliance with prescribed oral and inhaled asthma medications
21. The effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma
22. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: Effect of inhaled glucocorticoid
23. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma