Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos

Current Biology

Volumn 12, Issue 13, 2002, Pages 1124-1129

  Trieselmann, Nadia ^a   Wilde, Andrew ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BETA KARYOPHERINS; CELL CYCLE; DROSOPHILA; DROSOPHILA PROTEINS; GLUTATHIONE TRANSFERASE; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NUCLEAR LOCALIZATION SIGNAL; RAN GTP-BINDING PROTEIN; RECOMBINANT FUSION PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; CELL CYCLE PROTEINS; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS;

HEXAPODA; INSECTA;

CELL CYCLE PROTEIN; DROSOPHILA PROTEIN; GLUTATHIONE TRANSFERASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYBRID PROTEIN; KARYOPHERIN BETA; NUCLEAR PROTEIN; RAN PROTEIN; SEGREGATION DISTORTER PROTEIN, DROSOPHILA;

ANIMAL; ARTICLE; CELL CYCLE; DROSOPHILA; METABOLISM; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NUCLEAR LOCALIZATION SIGNAL; PHYSIOLOGY; PRENATAL DEVELOPMENT;

EID: 0037046808     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00934-X     Document Type: Article

References (29)

1. Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?
2. The ran GTPase regulates mitotic spindle assembly
3. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
4. Stimulation of microtubule aster and spindle assembly by the small GTPase Ran
5. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
6. Ran stimulates spindle assembly by changing microtubule dynamics and the balance of motor activities
7. Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
8. Importin β is a mitotic target of the small GTPase Ran in spindle assembly
9. Ran induces spindle assembly by reversing the inhibititory effect of importin α on TPX2 activity
10. Role of importin-β in coupling Ran to downstream targets in microtubule assembly
11. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
12. Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B
13. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts
14. The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1
15. Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S. cerevisiae
16. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
17. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles
18. Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization
19. Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina
20. Cytoplasmic dynein as a facilitator of nuclear envelope breakdown
21. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
22. GTP hydrolysis by Ran is required for nuclear envelope assembly
23. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo
24. Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system
25. Time-resolved, in vivo structures of mitotic spindle formation and nuclear lamina breakdown in Drosophila embryos
26. Role of importin-β in the control of nuclear envelope assembly by Ran
27. A His2AvDGFP fusion gene complements a lethal His2AvD mutant allele and provides an in vivo marker for Drosophila chromosome behavior
28. Nuclear mislocalization of enzymatically active RanGAP causes segregation distortion in Drosophila
29. The fusome organizes the microtubule network during oocyte differentiation in Drosophila