Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1423-1432

  Astles, Peter C ^a   Ashton, Michael J ^a   Bridge, Andrew W ^a   Harris, Neil V ^a   Hart, Terrance W ^a   Parrott, David P ^a   Porter, Barry ^a   Riddell, David ^a   Smith, Christopher ^a   Williams, Robert J ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1,3 DIOXOLAN 2 YL) 4,5 DIPHENYL 1H IMIDAZOLE; 2 (4,5 DIPHENYL 1H IMIDAZOL 2 YL) 5 METHYL 5 [4 (THIOMORPHOLIN 1 YL) 1 BUTYL] 1,3 DIOXANE; 2 [5 (3,5 DIMETHYL 1 PYRAZOLYL)PENTYLSULFINYL] 4,5 DIPHENYLIMIDAZOLE; 5 [(3,5 DIMETHYL 1 PYRAZOLYL)METHYL] 2 (4,5 DIPHENYL 1H IMIDAZOL 2 YL) 5 METHYL 1,3 DIOXANE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; PD 132301; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARTERIOSCLEROSIS; BIOLOGICAL AVAILABILITY; DIOXANES; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RABBITS; RATS; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029972867     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9505876     Document Type: Article

References (43)

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