Traceless linker: Oxidative activation and displacement of a sulfur-based linker

Tetrahedron Letters

Volumn 38, Issue 2, 1997, Pages 211-214

  Gayo, Leah M ^a   Suto, Mark J ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC COMPOUND; PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; TECHNIQUE;

EID: 0031032613     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02256-3     Document Type: Article

References (8)

1. Backes, J. B.; Ellman, J. A. J. Am. Chem. Soc. 1994, 116, 11171-11172, Backes, J. B.; Virgilio, A. A.; Ellman, J. A. J. Am. Chem. Soc. 1996, 118, 3055 - 3056.
2. Backes, J. B.; Ellman, J. A. J. Am. Chem. Soc. 1994, 116, 11171-11172, Backes, J. B.; Virgilio, A. A.; Ellman, J. A. J. Am. Chem. Soc. 1996, 118, 3055 - 3056.
3. Sucholeiki, I. Tetrahedron Lett., 1994, 55, 7307 - 7310.
4. Plunkett, M. J.; Ellman, J. A. J. Org, Chem. 1995, 60, 6006 - 6007, Chenera, B.; Finkelstein, J. A.; Veber, D. F. J. Am. Chem. Soc. 1995, 117, 11999-12000.
5. Plunkett, M. J.; Ellman, J. A. J. Org, Chem. 1995, 60, 6006 - 6007, Chenera, B.; Finkelstein, J. A.; Veber, D. F. J. Am. Chem. Soc. 1995, 117, 11999-12000.
6. NovaSyn® TG thiol resin was purchased from Calbiochem-Novabiochem Corp., P.O. Box 12087, La Jolla, CA 92039-2087. Pyrimidine l is also commercially available from Ryan Scientific, Inc., P.O. Box 845, Isle of Palms, SC 29451-0845.
7. 2O, 65:35 (1% TFA)] 94% purity.
8. In preliminary studies, we have synthesized the pyrimidine 2 starting from the activated diketoderivative and resin-bound thiourea. equation presented?