TPE or not TPE? It's no longer a question

Trends in Pharmacological Sciences

Volumn 23, Issue 1, 2002, Pages 1-4

  Wood, Jason G ^a   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; HISTONE DEACETYLASE; KU ANTIGEN; NICOTINAMIDE; PROTEIN; RAP PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; TRICHOSTATIN A; UNCLASSIFIED DRUG;

AGING; CELL AGING; CELL CYCLE PHASE; CHROMOSOME STRUCTURE; DEACETYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INSERTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; TELOMERE; TELOMERE POSITION EFFECT;

EID: 0036160259     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01891-5     Document Type: Review

References (20)

1. The limited in vitro lifetime of human diploid fibroblasts
2. Telomeres and telomerase: Implications for cancer and aging
3. A role for both RB and p53 in the regulation of human cellular senescence
4. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
5. Cell biology. Telomere capping - One strand fits all
6. Telomere positional effects and the regulation of cellular senescence
7. Turning telomeres off and on
8. Position effect of human telomeric repeats on replication timing
9. Non-programmed and engineered chromosome breakage
10. Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability
11. Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing
12. Effect of telomere length on telomeric gene expression
13. Telomere position effect in human cells
14. TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
15. Telomere structure regulates the heritability of repressed subtelomeric chromatin in Saccharomyces cerevisiae
16. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
17. Transient expression of human telomerase extends the life span of normal human fibroblasts
18. Aging in Saccharomyces cerevisiae
19. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
20. Age-dependent silencing of globin transgenes in the mouse