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Journal of Organic Chemistry

Volumn 67, Issue 6, 2002, Pages 1866-1872

Protease-mediated fragmentation of p-amidobenzyl ethers: A new strategy for the activation of anticancer prodrugs

(4) Toki, Brian E a Cerveny, Charles G a Wahl, Alan F a Senter, Peter D a

a SEATTLE GENETICS INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGMENTATION;

ACTIVATION ENERGY; AMINO ACIDS; ETHERS; TUMORS;

ORGANIC CHEMICALS;

1 NAPHTHOL; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALINE CITRULLINE 4 AMIDOBENZYL 3' O COMBRETASTATIN A4; CATHEPSIN B; CITRULLINE; COMBRETASTATIN A4; CYTOTOXIC AGENT; ETOPOSIDE; N ACETYLNOREPHEDRINE; NOREPHEDRINE; PEPTIDE; PRODRUG; PROTEINASE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR MODEL; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS; BENZYL ALCOHOLS; CATALYSIS; CATHEPSIN B; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHOLS; PHENYL ETHERS; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 0037155531 PISSN: 00223263 EISSN: None Source Type: Journal
DOI: 10.1021/jo016187+ Document Type: Article

Times cited : (89)

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