Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate

Journal of Controlled Release

Volumn 69, Issue 3, 2000, Pages 399-412

  Harada, Mitsunori ^a   Sakakibara, Hiroyuki ^a   Yano, Toshiro ^a   Suzuki, Takehiko ^a   Okuno, Satoshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Camptothecin; Cathepsin B; Drug release; Drug polymer conjugate; Lysosome

Indexed keywords

CAMPTOTHECIN DERIVATIVE; CATHEPSIN B; CYSTEINE PROTEINASE; LYSOSOME ENZYME; POLYMER; T 0128; T 2513; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG RELEASE; ENZYME SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; LIVER LYSOSOME; LYSOSOME; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATTLE; CYSTEINE ENDOPEPTIDASES; DEXTRANS; DIPEPTIDES; HUMANS; LEUCINE; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; PRODRUGS; RATS; SOLUBILITY; SPECIES SPECIFICITY; TOPOTECAN;

EID: 0034602592     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00321-7     Document Type: Article

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