The N-end rule pathway of protein degradation

Genes to Cells

Volumn 2, Issue 1, 1997, Pages 13-28

  Varshavsky, Alexander ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; DNA DIRECTED RNA POLYMERASE; FUNGAL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGASE; PEPTIDE FRAGMENT; PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBR1 PROTEIN, S CEREVISIAE;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; CYTOSOL; ENZYME SPECIFICITY; GENETICS; HALF LIFE TIME; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; ONCOGENE; REVIEW; SINDBIS VIRUS; TRANSPORT AT THE CELLULAR LEVEL;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CYTOSOL; DNA-DIRECTED RNA POLYMERASES; EVOLUTION, MOLECULAR; FUNGAL PROTEINS; GENES, MOS; GTP-BINDING PROTEINS; HALF-LIFE; LIGASES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SINDBIS VIRUS; SUBSTRATE SPECIFICITY; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 0030632048     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1997.1020301.x     Document Type: Article

References (5)

1. Alagramam, K., Naider, F. & Decker, J.M. (1995) A recognition component of the ubiquitin system is required for peptide transport in Saccharomyces cerevisiae. Mol. Microbiol. 15, 225-234.
2. Arfin, S.M. & Bradshaw, S.A. (1988) Cotranslational processing and protein turnover in eukaryotic cells. Biochemistry 27, 7979-7984.
3. Arnason, T.A. & Ellison, M.J. (1994) Stress resistance in S. cerevisiae is stronglycorrelated with assembly of a novel type of multiubiquitin chain. Mol. Cell. Biol. 14, 7876-7883.
4. Bartel, B., Wünning, I. & Varshavsky, A. (1990) The recognition component of the N-end rule pathway. EMBO J. 9, 3179-3189.
5. Chau, V., Tobias, J.W., Bachmair, A. et al. (1989) A multiubiquitin chain is confined to a specific lysine in a targeted short-lived protein. Science 243, 1576-1583.