Separase: A conserved protease separating more than just sisters

Trends in Cell Biology

Volumn 12, Issue 1, 2002, Pages 1-3

  Ross, Karen E ^a   Cohen Fix, Orna ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; SEPARASE; UNCLASSIFIED DRUG;

ANAPHASE; CELL; CELL DIVISION; CHROMOSOME; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; METAPHASE; MITOSIS; MOLECULAR EVOLUTION; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; SISTER CHROMATID;

EID: 0036168409     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02202-4     Document Type: Review

References (21)

1. Isolation and characterization of Schizosaccharomyces pombe cut mutants that block nuclear division but not cytokinesis
2. Splitting the chromosome: Cutting the ties that bind sister chromatids
3. Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans
4. Drosophila Separase is required for sister chromatid separation and binds to PIM and THR
5. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
6. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
7. Sister chromatid separation: Falling apart at the seams
8. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
9. Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability
10. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
11. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
12. Characterization of fission yeast cohesin: Essential anaphase proteolysis of Rad21 phosphorylated in the S phase
13. Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin
14. A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: Evidence that proper spindle association of Esp1 is regulated by Pds1
15. Slk19p is a centromere protein that functions to stabilize mitotic spindles
16. Orchestrating anaphase and mitotic exit: Separase cleavage and localization of Slk19
17. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis
18. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
19. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene
20. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis
21. Securin is required for chromosomal stability in human cells