Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines

Journal of Medicinal Chemistry

Volumn 45, Issue 13, 2002, Pages 2857-2866

  Ouyang, Hui ^a   Morris Natschke, Susan L ^a   Ishaq, Khalid S ^a   Ward, Peter ^b,d   Liu, Dongzhou ^a,c   Leonard, Sarah ^b   Thakker, Dhiren R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c PFIZER INC   (United States)

^d Arvna Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCARBON; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PHOSPHORYLCHOLINE; PROPYLPHOSPHOCHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL MEMBRANE PERMEABILITY; CELL STRAIN; CORRELATION ANALYSIS; DOG; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; HYDROPHILICITY; LINEAR SYSTEM; MEMBRANE FLUIDITY; MICELLE; NONHUMAN; REACTION ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DOGS; ENZYME INHIBITORS; ESTRENES; HUMANS; MANNITOL; MEMBRANE FLUIDITY; MICELLES; PERMEABILITY; PHOSPHOLIPASE C; PHOSPHORYLCHOLINE; PYRROLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TIGHT JUNCTIONS;

EID: 0037142307     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020001x     Document Type: Article

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