Elimination of the hydrolytic water molecule in a class A β-lactamase mutant: Crystal structure and kinetics

Biochemistry

Volumn 35, Issue 51, 1996, Pages 16475-16482

  Zawadzke, Laura E ^a   Chen, Celia C H ^a   Banerjee, Soojay ^a   Li, Zhong ^a   Wäsch, Susana ^a   Kapadia, Geeta ^a   Moult, John ^a   Herzberg, Osnat ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE; MUTANT PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

BASE SEQUENCE; BETA-LACTAMASES; BINDING SITES; CEPHALOSPORINS; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ELECTROCHEMISTRY; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PENICILLIN G; POINT MUTATION; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY; WATER;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 0030467025     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962242a     Document Type: Article

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