Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide:class II MHC complexes

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3263-3272

  Ramachandra, Lakshmi ^a   Song, Rui ^a   Harding, Clifford V ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL FRACTIONATION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; HYBRIDOMA; INTERNALIZATION; INTRACELLULAR TRANSPORT; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL FRACTIONATION; CELL MEMBRANE; CENTRIFUGATION, DENSITY GRADIENT; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MACROMOLECULAR SUBSTANCES; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSPHERES; MURAMIDASE; OVALBUMIN; PEPTIDE FRAGMENTS; PEPTIDES; PHAGOSOMES; SUBCELLULAR FRACTIONS; T-LYMPHOCYTES;

EID: 0033559901     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Peters, P. J., J. J. Neefjes, V. Oorschot, H. L. Ploegh, and H. J. Geuze. 1991. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature 349:669.
2. Amigorena, S., J. R. Drake, P. Webster, and I. Mellman. 1994. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature 369:113.
3. Riberdy, J. M., R. R. Avva, H. J. Geuze, and P. Cresswell. 1994. Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J. Cell Biol. 125:1225.
4. Morton, P. A., M. L. Zacheis, K. S. Giacoletto, J. A. Manning, and B. D. Schwartz, 1995. Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells. J. Immunol. 154: 137.
5. Qiu, Y., X. Xu, A. Wandinger-Ness, D. P. Dalke, and S. K. Pierce. 1994. Separation of subcellular compartments containing distinct functional forms of MHC class II. J. Cell Biol. 125:595.
6. Sanderson, F., M. J. Kleijmeer, A. Kelly, D. Verwoerd, A. Tulp, J. J. Neefjes, H. J. Geuze, and J. Trowsdale. 1994. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 266:1566.
7. Karlsson, L., A. Peleraux, R. Lindstedt, M. Liljedahl, and P. A. Peterson. 1994. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266:1569.
8. Liljedahl, M., T. Kuwana, W.-P. Fung-Leung, M. R. Jackson, P. A. Peterson, and L. Karlsson. 1996. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J. 15:4817.
9. Liljedahl, M., O. Winqvist, C. D. Surh, P. Wong, K. Ngo, L. Teyton, P. A. Peterson, A. Brunmark, A. Y. Rudensky, W. P. Fung-Leung, and L. Karlsson. 1998. Altered antigen presentation in mice lacking H2-O. Immunity 8:233.
10. Pierre, P., L. K. Denzin, C. Hammond, J. R. Drake, S. Amigorena, P. Cresswell, and I. Mellman. 1996. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments. Immunity 4:229.
11. Kleijmeer, M. J., S. Morkowski, J. M. Griffith, A. Y. Rudensky, and H. J. Geuze. 1997. Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. J. Cell Biol. 139:639.
12. Harding, C. V., and H. J. Geuze. 1993. Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment. J. Immunol. 151:3988.
13. Germain, R. N., and L. R. Hendrix. 1991. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature 353:134.
14. Castellino, F., and R. N. Germain. 1995. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity 2:73.
15. Tulp, A., D. Verwoerd, B. Dobberstein, H. L. Ploegh, and J. Pieters. 1994. Isolation and characterization of the intracellular MHC class II compartment. Nature 369:120.
16. West, M. A., J. M. Lucocq, and C. Watts. 1994. Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells. Nature 369:147.
17. Rudensky, A. Y., M. Maric, S. Eastmen, L. Shoemaker, P. C. DeRoos, and J. S. Blum. 1994. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1:585.
18. Amigorena, S., P. Webster, J. Drake, J. Newcomb, P. Cresswell, and I. Mellman. 1995. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J. Exp. Med. 181:1729.
19. Griffin, J. P., R. Chu, and C. V. Harding. 1997. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms. J. Immunol. 158:1523.
20. Escola, J.-M., J.-C. Grivel, P. Chavrier, and J.-P. Gorvet. 1995. Different endocytic compartments are involved in the tight association of class II molecules with processed hen egg lysozyme and ribonuclease A in B cells. J. Cell Sci. 108:2337.
21. Harding, C. V. 1995. Phagocytic processing of antigens for presentation by MHC molecules. Trends Cell Biol. 5:105.
22. Clemens, D. L., and M. A. Horwitz. 1992. Membrane sorting during phagocytosis: selective exclusion of major histocompatibility complex molecules but not complement receptor CR3 during conventional and coiling phagocytosis. J. Exp. Med. 175:1317.
23. Clemens, D. L., and M. A. Horwitz. 1995. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J. Exp. Med. 181:257.
24. Harding, C. V., and H. J. Geuze. 1992. Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells. J. Cell Biol. 119: 531.
25. Lang, T., and P. Kaye. 1991. Presentation of Leishmania donovani promastigotes occurs via a brefeldin A-sensitive pathway. Eur. J. Immunol. 21:2407.
26. Antoine, J. C., C. Jouanne, T. Lang, E. Prina, C. de Chastellier, and C. Frehel. 1991. Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis. Infect. Immun. 59:764.
27. Russell, D. G., S. Xu, and P. Chakraborty. 1992. Intracellular trafficking and the parasitophorous vacuole of Leishmania mexicana-infected macrophages. J. Cell Sci. 103:1193.
28. Clemens, D. L., and M. A. Horwitz. 1993. Hypoexpression of major histocompatibility complex molecules on Legionella pneumophila phagosomes and phagolysosomes. Infect. Immun. 61:2803.
29. Pitt, A., L. S. Mayorga, A. L. Schwartz, and P. D. Stahl. 1992. Transport of phagosomal components to an endosomal compartment. J. Biol. Chem. 267:126.
30. Ramachandra, L., R. M. Sramkoski, D. H. Canaday, W. H. Boom, and C. V. Harding. 1998. Flow analysis of MHC molecules and other membrane proteins in isolated phagosomes. J. Immunol. Methods 213:53.
31. Harding, C. 1997. Choosing and preparing antigen-presenting cells. In Current Protocols in Immunology. J. E. Coligan, D. H. Margulies, E. M. Shevach, W. Strober, and A. M. Kruisbeek, eds. Wiley, New York, p. 16.1.1.
32. Harding, C. V. 1992. Electroporation of exogenous antigen into the cytosol for antigen processing and class I major histocompatibilily complex (MHC) presentation: weak base amines and hypothermia (18°C) inhibit the class I MHC processing pathway. Eur. J. Immunol 22:1865.
33. lo thymocytes in vivo. Science 250: 1720.
34. Koch, N., S. Koch, and G. J. Hammerling. 1982. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody. Nature 299:644.
35. Harding, C. 1997. Methods for studying antigen processing and presentation. In Current Protocols in Immunology. J. E. Coligan, D. H. Margulies, E. M. Shevach, W. Strober, and A. M. Kruisbeek, eds. Wiley, New York, p. 16.0.1.
36. Ahmed, S. A., R. M. Gogal, Jr., and J. E. Walsh. 1994. A new rapid, and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to H3-thymidine incorporation assay. J. Immunol. Methods 170: 211.
37. Desjardins, M., L. A. Huber, R. G. Parton, and G. Griffiths. 1994. Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus. J. Cell Biol. 124:677.
38. Kappler, J., R. Kubo, K. Haskins, J. White, and P. Marrack. 1983. The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas. Cell 34:727.
39. Cresswell, P. 1994. Assembly, transport and function of MHC class II molecules. Annu. Rev. Immunol. 12:259.
40. Harding, C. V., and E. R. Unanue. 1989. Antigen processing and intracellular Ia: possible roles of endocytosis and protein synthesis in Ia function. J. Immunol. 142:12.