Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration

Journal of Biological Chemistry

Volumn 277, Issue 42, 2002, Pages 39981-39988

  Shi, Wuxian ^a   Sarver, Anne E ^a   Wang, Ching C ^a   Tanaka, Kelly S E ^b   Almo, Steven C ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTALLIZATION; DIMERS; MONOMERS;

PROTONATION;

ENZYMES;

9 DEAZAADENINE; ADENINE PHOSPHORIBOSYLTRANSFERASE; ADENOSINE PHOSPHATE; OROTATE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CIS TRANS ISOMERISM; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; EVOLUTION; GEOMETRY; GIARDIA LAMBLIA; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TRANSPORT; PROTON TRANSPORT;

ADENINE; ADENINE PHOSPHORIBOSYLTRANSFERASE; ADENOSINE MONOPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ARGININE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CLONING, MOLECULAR; GIARDIA LAMBLIA; GUANINE; HYDROGEN BONDING; KINETICS; LIGANDS; MAGNESIUM; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

GIARDIA; GIARDIA INTESTINALIS; PROTOZOA;

EID: 0037131284     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205596200     Document Type: Article

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