The maternally transcribed gene p57KIP2 (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles

Human Molecular Genetics

Volumn 11, Issue 26, 2002, Pages 3267-3272

  Fisher, Rosemary A ^a   Hodges, Matthew D ^a   Rees, Helene C ^b   Sebire, Neil J ^b   Seckl, Michael J ^a   Newlands, Edward S ^a   Genest, David R ^c   Castrillon, Diego H ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P57;

ARTICLE; CHROMOSOME 19Q; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETIC IDENTIFICATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME IMPRINTING; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN GENOME; HYDATIDIFORM MOLE; HYPERPLASIA; MULTIGENE FAMILY; PLACENTA VILLUS; PREGNANCY DISORDER; PRIORITY JOURNAL; REGULATORY MECHANISM; TROPHOBLASTIC DISEASE;

CHROMOSOMES, HUMAN, PAIR 19; CYCLIN-DEPENDENT KINASE INHIBITOR P57; FEMALE; GENOMIC IMPRINTING; HUMANS; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; MALE; NUCLEAR PROTEINS; PEDIGREE; PREGNANCY; UTERINE NEOPLASMS;

EID: 0037115725     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.26.3267     Document Type: Article

References (38)

1. Szulman, A.E. and Surti, U. (1978) The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am. J. Obstet. Gynecol., 131, 665-671.
2. Lawler, S.D., Fisher, R.A., Pickthall, VJ., Povey, S. and Evans, M.W. (1982) Genetic studies on hydatidiform moles. I. The origin of partial moles. Cancer Genet. Cytogenet., 5, 309-320.
3. Jacobs, P.A., Szulman, A.E., Funkhouser, J., Matsuura, J.S., Wilson, C.C. and Szulman, A.E. (1982) Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole. Ann. Hum. Genet., 46, 223-231.
4. Zaragoza, M.V., Surti. U., Redline, R.W., Millie, E., Chakravarti, A. and Hassold, T.J. (2000) Parental origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and association with the partial hydatidiform mole. Am. J. Hum. Genet., 66, 1807-1820.
5. Kajii, T. and Ohama, K. (1977) Androgenetic origin of hydatidiform mole. Nature, 268, 633-634.
6. Wake, N., Takagi, N. and Sasaki, M. (1978) Androgenesis as a cause of hydatidiform mole. J. Natl. Cancer Inst., 60, 51-57.
7. Ohama, K., Kajii, T., Okamoto, E., Fukada, Y., Imaizumi, K., Tsukahara, M., Kobayashi, K. and Hagiwara, K. (1981) Dispermic origin of XY hydatidiform moles. Nature, 292, 551-552.
8. Vejerslev, L.O., Fisher, R.A., Surti, U. and Wake, N. (1987) Hydatidiform mole: Cytogenetically unusual cases and their implications for the present classification. Am. J. Obstet. Gynecol., 157, 180-184.
9. Ko, T.-M., Hsieh C.-Y., He, H.-N., Hsieh, F.-J. and Lee, T.-Y. (1991) Restriction fragment length polymorphism analysis to study the genetic origin of hydatidiform mole. Am. J. Obstet. Gynecol., 164, 901-906.
10. Kovaks, B.W., Shahbahrami, B., Tast, D.E. and Curtin, J.P. (1991) Molecular genetic analysis of complete hydatidiform moles. Cancer Genet. Cytogenet., 54, 143-152.
11. Fisher, R.A., Paradinas, F.J., Soteriou, B.A., Foskett, M. and Newlands, E.S. (1997) Diploid hydatidiform moles with fetal red blood cells in molar villi: 2-Genetics. J. Pathol., 181, 189-195.
12. Helwani, M.N., Seoud, M., Zahed, L., Zaatari, G., Khalil, A. and Slim, R. (1999) A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution. Hum. Genet., 105, 112-115.
13. Fisher, R.A., Khatoon, R., Paradinas, F.J., Roberts, A.R and Newlands, E.S. (2000) Repetitive complete hydatidiform mole can be biparental in origin and either male or female. Hum. Reprod., 15, 594-598.
14. Moglabey, Y.B., Kircheisen, R., Seoud, M., Mogharbel, N.E., Van den Veyver, I. and Slim, R. (1999) Genetic mapping of a maternal locus responsible for familial hydatidiform moles. Hum. Mol. Genet., 8, 667-671.
15. Sensi, A., Gualandi, F., Pittalis, M.C., Calabrese, O., Falciano, F., Maestri, I., Bovicelli, L. and Calzolari, E. (2000) Mole maker phenotype: possible narrowing of the candidate region. Eur. J. Hum. Genet., 8, 641-644.
16. KIP2, on chromosome 11p15. Proc. Natl. Acad. Sci., 93, 3026-3030.
17. KIP2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease. Lab. Invest., 78, 269-276.
18. KIP2. Am. J. Surg. Pathol., 25, 1225-1230.
19. Lander, E.S. and Botstein, D. (1987). Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science, 236, 1567-1570.
20. Lander, E.S., Linton, L.M,, Birren, B., Nusbaum, C., Zody, M.C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W. et al. (2001) Initial sequencing and analysis of the human genome. Nature, 409, 860-921.
21. Mowery-Rushton, P.A., Driscoll, D.J., Nicholls, R.D., Locker, J. and Surti, U. (1996) DNA methylation patterns in human tissues of uniparental origin using a zinc-finger gene (ZNF127) from the Angelman/Prader-Willi region. Am. J. Med. Genet., 61, 140-146.
22. Kamiya, M., Judson, H., Okazaki, Y., Kusakabe, M., Muramatsu, M., Takada, S., Takagi, N., Arima, T., Wake, N. Kamimura, K. et al. (2000) The cell cycle control gene ZAC/PLAGL1 is imprinted-a strong candidate gene for transient neonatal diabetes. Hum. Mol. Genet., 9, 453-460.
23. Arima, T., Drewell, R.A., Oshimura, M., Wake, N. and Surani, M.A. (2000) A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. Genomics, 67, 248-255.
24. Ariel, I., Lustig, O., Oyer, C.E., Elkin, M., Gonik, B., Rachmilewitz, J., Biran, H., Goshen, R., De Groot, N. and Hochberg, A. (1994) Relaxation of imprinting in trophoblastic disease. Gynecol. Oncol., 53, 211-219.
25. Walsh, C., Miller, S.J., Flam, F., Fisher, R.A. and Ohlsson, R. (1995) Paternally-derived H19 is differentially expressed in malignant and non-malignant trophoblast. Cancer Res., 55, 1111-1116.
26. Judson, H., Hayward, B.E., Sheridan, E. and Bonthron, D.T. (2002) A global disorder of imprinting in the human female germ line. Nature, 416, 539-542.
27. Obata, Y., Kaneko-Ishino, T., Koide, T., Takai, Y., Ueda, T., Domeki, I., Shiroishi, T., Ishino, F. and Kono, T. (1998) Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis. Development, 125, 1553-1560.
28. Cleary, M.A., van Raamsdonk, C.D., Levorse, J., Zheng, B., Bradley, A. and Tilghman, S.M. (2001) Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat. Genet., 29, 78-82.
29. Fitzpatrick, G.V., Soloway, P.D. and Higgins, M.J. (2002) Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet., 32, 426-431.
30. KIP2 indicates a role in Beckwith Wiedemann syndrome. Nature, 387, 151-158.
31. Takahashi, K., Kobayashi, T. and Kanayama, N. (2000) p57(Kip2) regulates the proper development of labyrinthine and spongiotrophoblasts. Mol. Hum. Reprod., 6, 1019-1025.
32. Maher, E.R. and Reik, W. (2000) Beckwith-Wiedemann syndrome: imprinting in clusters revisited. J. Clin. Invest., 105, 247-252.
33. Paradinas, F.J., Sebire, N.J., Fisher, R.A., Rees, H.C., Foskett, M., Seckl, M.J. and Newlands, E.S. (2001) Pseudo-partial moles; placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles. Histopathology, 39, 447-454.
34. Bagshawe, K.D. and Lawler, S.D. (1982). Choriocarcinoma. In Schottenfeld, D. and Fraumeni, J.F. (eds.), Cancer Epidemiology and Prevention. Saunders, Philadelphia, USA, pp. 909-924.
35. Buiting, K., Saitoh S., Gross, S., Dittrich, B., Schwartz, S., Nicholls R.D. and Horsthemke, B. (1995) Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nat. Genet., 9, 395-400.
36. Bourc'his, D., Xu, G.L, Lin, C.S., Bollman, B. and Bestor, T.H. (2001) Dnmt3L and the establishment of maternal genomic imprints. Science, 294, 2536-2539.
37. Aapola, U., Kawasaki, K., Scott, H.S., Ollila, J., Vihinen, M., Heino, M., Shintani, A., Kawasaki, K., Minoshima, S., Krohn, K. et al. (2000) Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. Genomics, 65, 293-298.
38. Paradinas, F.J., Browne, P., Fisher, R.A., Foskett, M., Bagshawe, K.D. and Newlands, E. (1996) A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non-molar hydropic abortions. Histopathology, 28, 101-110.