Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice

Nature Genetics

Volumn 29, Issue 1, 2001, Pages 78-82

  Cleary, Michele A ^a   Van Raamsdonk, Catherine D ^a,b   Levorse, John ^a   Zheng, Binhai ^c   Bradley, Allan ^d   Tilghman, Shirley M ^a  

^a PRINCETON UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1C; GENE PRODUCT; PROTEIN ACSL2; PROTEIN H19; PROTEIN IGF2; PROTEIN KCNQ1; PROTEIN KNCQ1OT1; PROTEIN TSSC3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BECKWITH WIEDEMANN SYNDROME; CHROMOSOME 7; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; GENE ACTIVITY; GENE CLUSTER; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE STRUCTURE; GENETIC RECOMBINATION; GENOME; GENOME IMPRINTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TELOMERE;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA PRIMERS; GENOMIC IMPRINTING; IN SITU HYBRIDIZATION, FLUORESCENCE; LINKAGE (GENETICS); MICE; MICE, INBRED C57BL; MULTIGENE FAMILY; TRANSLOCATION, GENETIC;

ANIMALIA;

EID: 0034862306     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng715     Document Type: Article

References (30)

1. Disruption of imprinting caused by deletion of the H19 gene region in mice
2. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
3. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster
4. Beckwith-Wiedemann syndrome: Imprinting in clusters revisited
5. Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway
6. An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome
7. Low frequency of p57KIP2 mutation in Beckwith-Wiedemann syndrome
8. Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors
9. Chromosome engineering in mice
10. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-IoxP recombination
11. Cre-mediated sitespecific translocation between nonhomologous mouse chromosomes
12. Engineering mouse chromosomes with Cre-IoxP: Range, efficiency, and somatic applications
13. Ablation of the CDK inhibitor p57KIP2 results in increased apoptosis and delayed differentiation during mouse development
14. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome
15. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes
16. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis
17. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse
18. Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting
19. LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids
20. A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome
21. Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome
22. Molecular biology. Mothers setting boundaries
23. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p5.5
24. Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain
25. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: Long-stretches of unusually well conserved intronic sequences of Kvlqt1 between mouse and human
26. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice
27. Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen syndrome
28. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
29. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene