Differential expression of p57(kip2), a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease

Laboratory Investigation

Volumn 78, Issue 3, 1998, Pages 269-276

  Chilosi, Marco ^a   Piazzola, Elena ^a   Lestani, Maurizio ^a   Benedetti, Alice ^a   Guasparri, Ilaria ^a   Granchelli, Giovanna ^a   Aldovini, Daniela ^b   Leonardi, Elena ^b   Pizzolo, Giovanni ^a   Doglioni, Claudio ^c   Menestrina, Fabio ^a   Mariuzzi, Gian Mario ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b Ospedale di Trento   (Italy)

^c SAN MARTINO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CDKN1C PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1C; ENZYME INHIBITOR; NUCLEAR PROTEIN;

ARTICLE; CARCINOGENESIS; CHORIOCARCINOMA; GENE EXPRESSION REGULATION; GENOME IMPRINTING; HUMAN; HUMAN TISSUE; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; NIDATION; PATHOGENESIS; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS REGULATION; SPONTANEOUS ABORTION; DRUG ANTAGONISM; FEMALE; GENETICS; METABOLISM; MOTHER; PLACENTA; PREGNANCY; PREGNANCY COMPLICATION; REFERENCE VALUE; TROPHOBLASTIC TUMOR; UTERUS CANCER;

CHORIOCARCINOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P57; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FEMALE; GENOMIC IMPRINTING; HUMANS; HYDATIDIFORM MOLE; MOTHERS; NUCLEAR PROTEINS; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, NEOPLASTIC; REFERENCE VALUES; TROPHOBLASTIC NEOPLASMS; UTERINE NEOPLASMS;

EID: 0031594344     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ariel I, Lustig RO, Oyer CE, Elkin M, Gonik B, Rachmilewitz J, Biran H, Goshen R, de Groot N, and Hochberg A (1994). Relaxation of imprinting in trophoblastic disease. Gynecol Oncol 53:212-219.
2. Arnholdt H, Meisel F, Fandrey K, and Lohrs U (1991). Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies. Virchows Arch B Cell Pathol 60:365-372.
3. Barlow DP (1995). Gametic imprinting in mammals. Science 270:1610-1613.
4. Berkowitz RS and Goldstein DP (1996). Chorionic tumors. N Engl J Med 335:1740-1748.
5. Brannan CI, Dees EC, Ingram RS, and Tilghman SM (1990). The product of the H19 gene may function as an RNA. Mol Cell Biol 10:28-36.
6. Brunkow CJ and Tighlman SM (1991). Ectopic expression of the H19 gene in mice causes prenatal death. Genes Dev 5:1092-1101.
7. Chilosi M, Doglioni C, Menestrina F, Lestani M, Piazzola E, Benedetti A, Pedron S, Montagna L, Pizzolo G, Mariuzzi GM, and Janossy G (1997). Expression of extracellular matrix molecules, proliferation markers and cyclin-dependent kinase inhibitors in inflamed tissues. Biochem Soc Trans 25:524-528.
8. Chilosi M, Doglioni C, Menestrina F, Montagna L, Rigo A, Lestani M, Barbareschi M, Scarpa A, Mariuzzi GM, and Pizzolo G (1994). Abnormal expression of the p53-binding protein mdm2 in Hodgkin's disease. Blood 84:4295-4300.
9. Conran RM, Hitchcock CL, Popek EJ, Norris HJ, Griffin JL, Geissel A, and McCarthy WF (1993). Diagnostic considerations in molar gestations. Hum Pathol 24:41-48.
10. De Chiara TM, Estratiadis A, and Robertson EJ (1990). A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78-80.
11. De Groot N and Hochberg A (1993). Gene imprinting during placental and embryonic development. Mol Reprod Dev 36:309-406.
12. Fisher RA and Newlands ES (1993). Rapid diagnosis and classification of hydatidiform moles with polymerase chain reaction. Am J Obstet Gynecol 168:563-569.
13. Fisher RA, Paradinas FJ, Soteriou BA, Foskett M, and Newlands ES (1997). Diploid hydatidiform moles with fetal red blood cells in molar villi:1 - Pathology, incidence, and prognosis. J Pathol 181:183-188.
14. Giannoukakis N, Deal C, Paquette J, Goodyear CG, and Polychronakos C (1993). Parental genomic imprinting of the human IGF2 gene. Nat Genet 4:98-101.
15. Goshen R, Ben-Rafael Z, Gonik B, Lustig O, Tannos V, de-Groot N, and Hochberg AA (1994). The role of genomic imprinting in implantation. Fertil Steril 62:903-910.
16. Hall JG (1990). Genomic imprinting: A review and relevance to human disease. Am J Hum Genet 46:857-873.
17. Hashimoto K, Azuma C, Koyama M, Ohashi K, Kamiura S, Nobunaga T, Kimura T, Tokugawa Y, Kanai T, and Saji F (1995). Loss of imprinting in choriocarcinoma. Nat Genet 9:109-110.
18. KIP2, a cyclin-dependent kinase inhibitor, in mouse. Nat Genet 11:204-206.
19. Hatada I, Ohashi H, Fukushima Y, Kaneko Y, Inoue M, Komoto Y, Okada A, Ohishi S, Nabetani A, Morisaki H, Nakayama M, Niikawa N, and Mukai T (1996). An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome. Nat Genet 14:171-173.
20. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, and Musgrove EA (1983). Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31:1333-1335.
21. Kajii T and Ohama K (1977). Androgenetic origin of hydatidiform mole. Nature 268:633-634.
22. Koenig C, Demopoulos RI, Vamvakas EC, Mittal KR, Feiner HD, and Espiritu EC (1993). Flow cytometric DNA ploidy and quantitative histopathology in partial moles. Int J Gynecol Pathol 12:235-240.
23. KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9:639-649.
24. CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9:650-662.
25. Matsuoka S, Thompson JS, Edwards MC, Bartletta JM, Grundy P, Kalikin LM, Harper JW, Elledge SJ, and Feinberg AP (1996). Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor p57KIP2, on chromosome 11p15. Proc Natl Acad Sci USA 93:3026-3030.
26. Montes M, Roberts D, Berkowitz RS, and Genest DR (1996). Prevalence and significance of implantation site trophoblastic atypia in hydatidiform moles and spontaneous abortions. Am J Clin Pathol 105:411-416.
27. Mutter GL, Stewart CL, Chaponot ML, and Pomponio RJ (1993). Oppositely imprinted genes H19 and insulin-like growth factor 2 are coexpressed in human androgenetic trophoblast. Am J Hum Genet 53:1096-1102.
28. Ohlsson R, Nystrom A, Pfeifer-Ohlsson S, Tohonen V, Hedborg F, Schofield P, Flam F, and Ekstrom TJ (1993). IGF2 is paternally imprinted during human embryogenesis and in the Beckwith-Wiedeman syndrome. Nat Genet 4:94-97.
29. Rachmilewitz J, Goshen R, Ariel I, Shneider T, de Groot N, and Hochberg A (1992). Parental imprinting of the human H19 gene. FEBS Lett 309:25-28.
30. Razin A and Cedar H (1994). DNA methylation and genomic imprinting. Cell 77:473-476.
31. Schammel DP and Bocklage T (1997). p53, PCNA, and Ki67 in hydropic molar and nonmolar placentas: An immunohistochemical study. Int J Gynecol Pathol 15:158-166.
32. Silverberg SG and Kurman RJ (1991). Atlas of tumor pathology: Tumors of the uterine corpus and gestationalal trophoblastic disease. Washington, D.C.: Armed Forces Institute of Pathology (AFIP).
33. Szulman AE and Surti U (1978). The syndromes of hydatidiform mole: I - Cytogenetic and morphological correlations. Am J Obstet Gynecol 131:665-671.
34. Tedde G and Tedde Piras A (1978). Mitotic index of the Langhans' cells in the normal human placenta from the early stages of pregnancy to the term. Acta Anat (Basel) 100:114-119.
35. Van De Kaa CA, Nelson KAY, Ramaekers FC, Vooijs PG, and Hopman AH (1991). Interphase cytogenetics in paraffin sections of routinely processed hydatidiform moles and hydropic abortions. J Pathol 165:281-287.
36. Walsh C, Miller SJ, Flam F, Fisher RA, and Ohlsson R (1995). Paternally derived H19 is differentially expressed in malignant and nonmalignant trophoblast. Cancer Res 55:1111-1116.
37. KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature 387:151-158.