MDM2 overexpression is associated with short survival in adults with medulloblastoma

Neuro-Oncology

Volumn 4, Issue 2, 2002, Pages 115-122

  Giordana, Maria Teresa ^a   Duó, Debora ^a   Gasverde, Sabrina ^a   Trevisan, Elisa ^a   Boghi, Andrea ^a   Morra, Isabella ^a   Pradotto, Luca ^a   Mauro, Alessandro ^a   Chió, Adriano ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

ADULT; AGE; APOPTOSIS; ARTICLE; CANCER CLASSIFICATION; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; EXON; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; LABELING INDEX; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; POLYMERASE CHAIN REACTION; RADIOSENSITIVITY; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR CELL; TUMOR LOCALIZATION; TUMOR SUPPRESSOR GENE;

ADULT; CEREBELLAR NEOPLASMS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; GENES, P53; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MEDULLOBLASTOMA; MIDDLE AGED; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036205588     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/S152285170100062X     Document Type: Article

References (33)

1. p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma
2. Prognostic implications of chromosome 17p deletions in human medulloblastomas
3. Amplification and overexpression of MDM2 in primary (de novo) glioblastomas
4. Medulloblastoma in adults: A review of 47 patients treated between 1952 and 1981
5. Multivariate analysis of prognostic factors in adult patients with medulloblastoma: Retrospective study of 156 patients
6. Adult medulloblastoma: Prognostic factors and patterns of relapse
7. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
8. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines
9. The p53 proto-oncogene can act as a suppressor of transformation
10. Prognostic factors in adult medulloblastoma: A clinico-pathologic study
11. Is medulloblastoma the same tumor in children and adults?
12. Treatment of medulloblastoma in adults
13. Cell type-specific inhibition of p53-mediated apoptosis by mdm2
14. Increased expression of mutant forms of p53 oncogene in primary lung cancer
15. Nonparametric estimation from incomplete observations
16. MDM2 and p53 expression in gliomas: A multivariate survival analysis including proliferation markers and epidermal growth factor receptor
17. Regulation of p53 stability by Mdm2
18. Survival and recurrence factors in adult medulloblastoma: The M.D. Anderson Cancer Center experience from 1978 to 1998
19. Epidemiology, cytogenetics, and molecular biology of brain tumors
20. Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
21. Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors
22. In vivo ubiquitination and proteosome-mediated degradation of p53
23. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
24. Expression of p53, MDM2 protein, and Ki-67 antigen in recurrent meningiomas
25. Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy
26. Design and analysis of randomized clinical trials requiring prolonged observations of each patient: Analysis and examples
27. CDKN2/p16 inactivation and p16 immunohistochemistry in astrocytic gliomas
28. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
29. Amplification at 12q13-14 in human malignant gliomas is frequently accompanied by loss of heterozygosity at loci proximal and distal to the amplification site
30. Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification
31. Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors
32. Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors
33. Metastasis stage, adjuvant therapy, and residual tumor are prognostic factors for medulloblastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase III study