Protein kinase A RIβ subunit deficiency in lupus T lymphocytes: Bypassing a block in RIβ translation reconstitutes protein kinase A activity and augments IL-2 production

Journal of Immunology

Volumn 166, Issue 12, 2001, Pages 7600-7605

  Khan, I U ^a   Laxminarayana, D ^a   Kammer, G M ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INTERLEUKIN 2; PHOSPHOTRANSFERASE; PROTEIN KINASE A RIBETA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SYNTHESIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRANSLATION INITIATION;

EID: 0035877052     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.12.7600     Document Type: Article

References (28)

1. Lupus: The clinical entity
2. Molecular aberrations in human systemic lupus erythematosus
3. Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus
4. Defective cAMP-dependent phosphorylation of intact T lymphocytes in active systemic lupus erythematosus
5. Deficient type I protein kinase activity in systemic lupus erythematosus T lymphocytes
6. High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus
7. Structure, function, and regulation of human cAMP-dependent protein kinases
8. Diminished levels of proteins kinase A RIα and RIβ transcripts and proteins in systematic lupus erythematosus T lymphocytes
9. Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotide
10. Human regulatory subunit RIβ of cAMP-dependent protein kinases: Expression, holoenzyme formation and microinjection into living cells
11. Early events of human T lymphocyte activation are associated with type I protein kinase A activity
12. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
13. Phosphorylation of phospholipase C-γ by camp-Dependent protein kinase
14. c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytes
15. Transcriptional regulation by cyclic AMP
16. High gradient magnetic cell separation with MACS
17. Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane
18. Molecular cloning, cDNA structure and tissue-specific expression of the human regulator subunit RIβ of cAMP-dependent protein kinases
19. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells: Convergence of costimulatory signals and differences from transformed T cells
20. Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes. II. Abnormal kinetics
21. Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: A molecular mechanism underlying long-term synaptic plasticity
22. The ubiquitin-proteasome pathway is required for processing the NF-κB 1 precursor protein and the activation of NF-κB
23. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
24. Inhibitors of proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
25. Characterization of in vitro-translated human regulatory and catalytic subunits of cAMP-dependent protein kinases
26. Cytokines in the immunopathogenesis of lupus
27. Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients