Human RNA helicase A is a lupus autoantigen that is cleaved during apoptosis

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 6269-6274

  Takeda, Yoshihiko ^a   Caudell, Patricia ^a   Grady, Giuia ^a   Wang, Grace ^b   Suwa, Akira ^a   Sharp, Gordon C ^b   Dynan, William S ^a   Hardin, John A ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CASPASE 3; ISOENZYME; RNA HELICASE;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME INACTIVATION; HELA CELL; HUMAN; HUMAN CELL; LUPUS ERYTHEMATOSUS NEPHRITIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; APOPTOSIS; AUTOANTIGENS; CASPASE 3; CASPASES; DEAD-BOX RNA HELICASES; HELA CELLS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; RNA HELICASES; SEQUENCE ANALYSIS, PROTEIN;

EID: 0033485431     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Tan, E. M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44:93.
2. von Mühlen, C. A., and E. M. Tan. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin. Arthritis Rheum. 24:323.
3. Casciola-Rosen, L. A., D. K. Miller, G. J. Anhalt, and A. Rosen. 1994. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem. 269:30757.
4. Casciola-Rosen, L. A., G. J. Anhalt, and A. Rosen. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182:1625.
5. McConnell, K. R., W. S. Dynan, and J. A. Hardin. 1997. The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells. J. Immunol. 158:2083.
6. Casciola-Rosen, L., D. W. Nicholson, T. Chong, K. R. Rowan, N. A. Thornberry, D. K. Miller, and A. Rosen. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J. Exp. Med. 183:1957.
7. Tewari, M., L. T. Quan, K. O'Rourke, S, Desnoyers, Z. Zeng, D. R. Beidler, G. G. Poirier, G. S. Salvesen, and V. M. Dixit. 1995. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801.
8. Casiano, C. A., S. J. Martin, D. R. Green, and E. M. Tan. 1996. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis. J. Exp. Med. 184:765.
9. Casiano, C. A., and E. M. Tan. 1996. Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis. Mol. Biol. Rep. 23:211.
10. Lee, C. G., and J. Hurwitz. 1992. A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3′ to 5′ direction. J. Biol. Chem. 267:4398.
11. Lee, C. G., and J. Hurwitz. 1993. Human RNA helicase A is homologous to the maleless protein of Drosophila. J. Biol. Chem. 268:16822.
12. Zhang, S. S., and F. Grosse. 1991. Purification and characterization of two DNA helicases from calf thymus nuclei. J. Biol. Chem. 266:20483.
13. Zhang, S., and F. Grosse. 1994. Nuclear DNA helicase II unwinds both DNA and RNA. Biochemistry 33:3906.
14. Zhang, S., H. Maacke, and F. Grosse. 1995. Molecular cloning of the gene encoding nuclear DNA helicase II. A bovine homologue of human RNA helicase A and Drosophila MIe protein. J. Biol. Chem. 270:16422.
15. Zhang, S., and F. Grosse. 1997. Domain structure of human nuclear DNA helicase II (RNA helicase A). J. Biol. Chem. 272:11487.
16. Nakajima, T., C. Uchida, S. F. Anderson, C. G. Lee, J. Hurwitz, J. D. Parvin, and M. Montminy. 1997. RNA helicase A mediates association of CBP with RNA polymerase II. Cell 90:1107.
17. Anderson, S. F., B. P. Schlegel, T. Nakajima, E. S. Wolpin, and J. D. Parvin. 1998. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19:254.
18. Lee, C. G., V. da Costa Soares, C. Newberger, K. Manova, E. Lacy, and J. Hurwitz. 1998. RNA helicase A is essential for normal gastrulation. Proc. Natl. Acad. Sci. USA 95:13709.
19. Tang, H., G. M. Gaietta, W. H. Fischer, M. H. Ellisman, and F. Wong-Staal. 1997. A cellular cofactor for the constitutive transport element of type D retro-virus. Science 276:1412.
20. Li, J., H. Tang, T. M. Mullen, C. Westberg, T. R. Reddy, D. W. Rose, and F. Wong-Staal. 1999. A role for RNA helicase A in post-transcriptional regulation of HIV type I. Proc. Natl. Acad. Sci. USA 96:709.
21. Northway, J. D., and E. M. Tan. 1972. Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence. Clin. Immunol. Immunopathol. 1:140.
22. Takeda, Y., K. S. Wise, G. Wang, G. Grady, E. V. Hess, G. C. Sharp, W. S. Dynan, and J. A. Hardin. 1998. Human autoantibodies recognizing a native macromolecular structure composed of Sm core proteins in U small nuclear RNP particles. Arthritis Rheum. 41:2059.
23. Pettersson, I., G. Wang, E. I. Smith, H. Wigzell, E. Hedfors, J. Horn, and G. C. Sharp. 1986. The use of immunoblotting and immunoprecipitation of (U) small nuclear ribonucleoproteins in the analysis of sera of patients with mixed connective tissue disease and systemic lupus erythemalosus: a cross-sectional, longitudinal study. Arthritis Rheum. 29:986.
24. Trauth, B. C., C Klas, A. M. Peters, S. Matzku, P. Moller, W. Falk, K. M. Debatin, and P. H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301.
25. Mimori, T., J. A. Hardin, and J. A. Steitz. 1986. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. Biol. Chem. 261:2274.
26. Samejima, K., P. A. Svingen, G. S. Basi, T. Kottke, P. W. Mesner, Jr., L. Stewart, F. Durrieu, G. G. Poirier, E. S. Alnemri, J. J. Champoux, et al. 1999. Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis. J. Biol. Chem. 274:4335.
27. Tan, E., A. Cohen, J. Fries, A. Masi, D. McShane, N. Rothfield, J. Schaller, N. Talal, and R. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271.
28. Thornberry, N. A., and Y. Lazebnik. 1998. Caspases: enemies within. Science 281:1312.
29. Brockstedt, E., A. Rickers, S. Kostka, A. Laubersheimer, B. Dorken, B. Wittmann-Liebold, K. Bommert, and A. Otto. 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line: cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. J. Biol. Chem. 273:28057.
30. Gibson, T. J., and J. D. Thompson. 1994. Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases. Nucleic Acids Res. 22:2552.
31. Rovere, P., C. Vallinoto, A. Bondanza, M. C. Crosti, M. Rescigno, P. Ricciardi-Castagnoli, C. Rugarli, and A. A. Manfredi. 1998. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J. Immunol. 161:4467.
32. Gammon, G., and E. Sercarz. 1989. How some T cells escape tolerance induction. Nature 342:183.
33. Ria, F., B. M. Chan, M. T. Scherer, J. A. Smith, and M. L. Gefter. 1990. Immunological activity of covalently linked T-cell epitopes. Nature 343:381.
34. Cibotti, R., J. M. Kanellopoulos, J. P. Cabaniols, O. Halle-Panenko, K. Kosmatopoulos, E. Sercarz, and P. Kourilsky. 1992. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc. Natl. Acad. Sci. USA 89:416.
35. Mamula, M. J., R. H. Lin, C. A. Janeway, Jr., and J. A. Hardin. 1992. Breaking T cell tolerance with foreign and self co-immunogens: a study of autoimmune B and T cell epitopes of cytochrome c. J. Immunol. 149:789.
36. Mamula, M. J. 1993. The inability to process a self-peptide allows autoreactive T cells to escape tolerance. J. Exp. Med. 177:567.
37. Mamula, M. J., S. Falenejad, and J. Craft. 1994. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. J. Immunol. 152:1453.
38. Warnock, M. G., and J. A. Goodacre. 1997. Cryptic T-cell epitopes and their role in the pathogenesis of autoimmune diseases. Br. J. Rheumatol. 36:1144.
39. Sercarz, E. E., P. V. Lehmann, A. Ametani, G. Benichou, A. Miller, and K. Moudgil. 1993. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11:729.