Differential distribution of laminins in Alzheimer disease and normal human brain tissue

Journal of Neuroscience Research

Volumn 69, Issue 2, 2002, Pages 243-256

  Palu, Edouard ^a   Liesi, Päivi ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Brain Laboratory   (Finland)

Author keywords

1 laminin; 1 laminin; Alzheimer disease; Reactive astrocytes; Senile plaques

Indexed keywords

ALPHA1 LAMININ; GAMMA1 LAMININ; ISOPROTEIN; LAMININ; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; ASTROCYTE; BRAIN TISSUE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE ASSOCIATION; FRONTAL CORTEX; GRAY MATTER; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENILE PLAQUE; TISSUE DISTRIBUTION; WESTERN BLOTTING; WHITE MATTER;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BLOTTING, WESTERN; FRONTAL LOBE; HUMANS; IMMUNOHISTOCHEMISTRY; LAMININ; NERVE GROWTH FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TUMOR SUPPRESSOR PROTEINS;

EID: 0037100183     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10292     Document Type: Article

References (61)

1. Alzheimer disease amyloid β protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminum
2. Key factors in Alzheimer disease: β-amyloid precursor protein processing, metabolism and intraneuronal transport
3. Agrin and microvascular damage in Alzheimer disease
4. Laminin inhibits amyloid-β-peptide fibrillation
5. Extracellular matrix regulates the amount of the β-amyloid precursor protein and its amyloidogenic fragments
6. Fibrillogenesis in Alzheimer disease of amyloid β peptides and apolipoprotein E
7. Laminin inhibition of β-amyloid protein (Aβ) fibrillogenesis and identification of an Aβ binding site localized to the globular domain repeats on the laminin a chain
8. Perlecan binds to the β-amyloid proteins (Aβ) of Alzheimer disease, accelerates Aβ fibril formation, and maintains Aβ fibril stability
9. Form and function: The laminin family of heterotrimers
10. Agrin binds to β-amyloid (Aβ), accelerates aβ fibril formation, and is localized to Aβ deposits in Alzheimer disease brain
11. Laminin-1 attenuates β-amyloid peptide (1-40) neurotoxicity of cultured fetal rat cortical neurons
12. Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer disease
13. Mapping of domains in human laminin using monoclonal antibodies: Localization of the neurite-promoting site
14. Alzheimer disease: An inflammatory disease?
15. Antibodies to fibronectin bind to plaques and other structures in Alzheimer and control brain
16. Interaction of agrin with laminin requires a coiled-coil conformation of the agrinbinding site within the laminin γ1 chain
17. A laminin graft can replace resuturing in the restorative surgery of sciatic nerve in the rat
18. β-amyloid precursor protein binds to the neuritepromoting IKVAV site of laminin
19. Presenilins and Alzheimer disease
20. Entactin-induced inhibition of human amyloid β-protein fibril formation in vitro
21. Gents for basement membrane proteins are coordinately expressed in differentiating F9 cells but not in normal adult murine tissues
22. Characterization and expression of the laminin γ3 chain: A novel, non-basement membrane-associated, laminin chain
23. Immunohistochemical study of Alzheimer disease using antibodies to synthetic amyloid and fibronectin
24. Monogenic determinants of familial Alzheimer disease: Presenilin-1 mutations
25. Neoplastic differentiation: Characteristics of cell lines derived from a murine teratocarcinoma
26. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
27. Do neurons in the vertebrate CNS migrate on laminin?
28. Ethanol-exposed neurons fail to migrate and undergo apoptosis
29. Neurons and glial cells of the embryonic human brain and spinal cord express multiple and distinct isoforms of laminin
30. Domain-specific antibodies against the B2 chain of laminin inhibit neuronal migration in the neonatal rat cerebellum
31. Induction of type IV collagen and other basement membrane associated proteins after spinal cord injury of the adult rat may participate in formation of the glial scar
32. A biologically active sequence (KD1) mediates the neurite outgrowth function of the γ1 chain of laminin-1
33. Identification of a neurite outgrowth-promoting domain of laminin using synthetic peptides
34. Weaver granule neurons are rescued by calcium channel blockers and antibodies against a neurite outgrowth domain of the β2 chain of laminin
35. A molecular gradient along the axon pathway is not required for axon guidance
36. The inhibitory effect of laminin 1 and synthetic peptides deduced from the sequence in the laminin α1 chain on Aβ40 fibril formation in vitro
37. Laminin inhibits Aβ 42 fibril formation in vitro
38. Inhibition of Aβ fibril formation and Aβ-induced cytotoxicity by senile plaque-associated proteins
39. Extracellular matrix influences the biogenesis of amyloids precursor protein in microglial cells
40. Interactions of laminin with the amyloid β peptide. Implications for Alzheimer disease
41. Laminin and its neurite outgrowth-promoting domain in the brain in Alzheimer disease and Down syndrome patients
42. Increased proteolytic activity of the granule neurons may contribute to neuronal death in the weaver mouse cerebellum
43. Characterization of high affinity binding between laminin and Alzheimer disease amyloid precursor proreins
44. α-1-antichymotrypsin promotes β-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer disease
45. The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer disease
46. Protease resistance and conformation of laminin
47. Association between vascular basement membrane components and the lesions of Alzheimer disease
48. Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains
49. Mutant genes in familial Alzheimer disease and transgenic models
50. Identification of synthetic peptides derived from laminin α1 and α2 chains with cell type specificity for neurite outgrowth
51. Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains
52. Translating cell biology into therapeutic advances in Alzheimer disease
53. Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: Their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the β1 integrin subunit
54. Binding of the G domains of laminin α1 and α2 chains and perlecan to heparin, sulfatides, α-dystroglycan and several matrix proteins
55. An IKLLI-containing peptide derived from the laminin α1 chain mediating heparin-binding, cell adhesion, neurite out-growth and proliferation, represents a binding site for integrin α3β1 and heparan sulphate proteoglycan
56. A synthetic peptide deduced from the sequence in the cross-region of laminin A chain mediates neurite outgrowth, cell attachment and heparin binding
57. Presence of laminin a5 chain and lack of laminin a1 chain during human muscle development and in muscular dystrophies
58. Structure and function of laminin LG modules
59. Binding partners of Alzheimer disease proteins: Are they physiologically relevant?
60. The cell biology of Alzheimer disease: Uncovering the secrets of secretase
61. Neurotrophic and neurotoxic effects of amyloid-β-proteins: Reversal by tachykinin neuropeptides