Neurons and glial cells of the embryonic human brain and spinal cord express multiple and distinct isoforms of laminin

Journal of Neuroscience Research

Volumn 64, Issue 2, 2001, Pages 144-167

  Liesi, Päivi ^a   Fried, Gabriel ^b   Stewart, Randall R ^c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Brain; Human embryo; Isoforms of laminin; Neurite outgrowth; Spinal cord

Indexed keywords

LAMININ; MONOCLONAL ANTIBODY; NETRIN; POLYCLONAL ANTIBODY; SYNAPTOTAGMIN;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; AUTOFLUORESCENCE; BRAIN CELL; CONTROLLED STUDY; EMBRYO (ANATOMY); ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; GLIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NERVE CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FETAL PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOSYLATION; HUMANS; LAMININ; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD; TUBULIN;

EID: 0035871967     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1061     Document Type: Article

References (63)

1. Developmental expression of nicein adhesion protein (laminin-5) subunits suggest multiple morphogenic roles
2. Structure of the human laminin g2 chain gene (LAMC2) alternative splicing with different tissue distribution of two transcripts
3. The role of laminins in basement membrane function
4. Nerve growth factor, laminin and fibronectin promote neurite outgrowth in human fetal sensory ganglia cultures
5. A new nomenclature for the laminins
6. Immunocytochemistry of a spontaneous murine ovarian teratoma with neuroepithelial differentiation. Neuron-associated beta-tubulin as a marker for primitive neuroepithelium
7. The role of laminin and the laminin/fibronectin receptor complex in the outgrowth of retinal ganglion cell axons
8. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
9. Form and function: The laminin family of heterotrimers
10. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
11. Expression of class III beta-tubulin isotype in developing neurons in culture
12. Characterization of N-CAM diversity in cultured neurons
13. The molecular biology of axon guidance
14. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis and receptor binding
15. Cellular prion protein binds laminin and mediates neuritogenesis
16. Laminins of the adult mammalian CNS; laminin-alpha2 (merosin M-) chain immunoreactivity is associated with neuronal processes
17. Differential expression of the laminin A and B chains in chimeric kidneys
18. A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction
19. Primary, sequence of a motor neuron-selective adhesive site in the synaptic basal lamina protein S-laminin
20. Expression of s-laminin and laminin in the developing rat central nervous system
21. The human laminin β2 chain (S-laminin): Structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene
22. Primary structure and expression of a novel human laminin α4 chain
23. A truncated laminin chain homologous to the B2 chain: Structure, spatial expression, and chromosomal assignment
24. A laminin graft replaces neurorrhaphy in the restorative surgery of the rat sciatic nerve
25. Characterization and expression of the laminin γ3 chain: A novel, non-basement membrane-associated, laminin chain
26. Identification of metastasis-promoting sequences in the mouse laminin
27. Structural analysis of a human glial variant laminin
28. Immunoreactivity for laminin in the developing longitudinal pathway of the brain
29. Disruption of laminin β2 chain production causes alterations in morphology and function in the CNS
30. Laminin immunoreactive glia distinguish regenerating adult CNS systems from non-regenerating ones
31. Do neurons in the vertebrate CNS migrate on laminin
32. Extracellular matrix and neuronal movement
33. Glial cells of the mammalian brain produce a variant form of laminin
34. Is glial laminin involved in axon guidance in the mammalian CNS?
35. Weaver granule neurons are rescued by calcium channel antagonists and antibodies against a neurite outgrowth domain of B2 chain of laminin
36. Laminin is produced by early rat astrocytes in primary culture
37. Neurons cultured from developing rat brain attach and spread preferentially to laminin
38. Laminin is induced in adult rat brain by stereotaxic lesioning
39. Identification of a neurite outgrowth-promoting domain of laminin using synthetic peptides
40. Domain specific antibodies against a neurite outgrowth domain of the B2 chain of laminin inhibit neuronal migration in neonatal rat cerebellum
41. Laminin and the mechanism of neuronal outgrowth
42. Laminin promotes neuritic regeneration from cultured peripheral and central neurons
43. A molecular gradient along the axon pathway is not required for axon guidance
44. Netrin-1 interaction with deleted in colorectal cancer (DCC) and alternations in brain tumor and neuroblastomas
45. The laminin α chains: Expression, developmental transitions, and chromosomal locations of α1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel α3 isoform
46. Roles for laminin in embryogenesis: Exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha 5 chain
47. Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: A new model of merosin (laminin 2)-deficient congenital muscular dystrophy
48. Laminin α2 chain (M chain) is found within the pathway of avian and murine retinal projections
49. Laminin and its neurite outgrowth promoting domain associate with the Alzheimer's and Down's syndrome brains
50. The renal glomerulus of mice lacking s-laminin/laminin β2: Nephrosis despite molecular compensation by laminin β1
51. A novel laminin B1 chain variant in avian eye
52. Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments
53. Expression of laminin isoforms in mouse myogenic cella in vitro and in vivo
54. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
55. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
56. Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: Their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the β1 intergrin subunit
57. A synthetic peptide containing the IKVAV sequense from the A chain of laminin mediates cell attachment, migration and neurite outgrowth
58. Laminin-a2-chain-like antigens in CNs dendritic spines
59. Presence of laminin α5 chain and lack of laminin α1 chain during human muscle development and in muscular dystrophies
60. Macromolecular organization of basement membranes
61. Laminin, a glycoprotein from basement membranes
62. Immunolocalization of several laminin chains in the normal human central and peripheral nervous system
63. Human laminin-M chain (merosin) - Complete primary structure, chrosomal assignment, and expression of the M-chain and A-chain in human fetal tissues