C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 mediator component

Genes and Development

Volumn 16, Issue 14, 2002, Pages 1815-1827

  Howard, Robyn M ^a   Sundaram, Meera V ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

EOR 1; EOR 2; PLZF; Ras; Wnt

Indexed keywords

GENE PRODUCT; PROTEIN EOR 1; PROTEIN EOR 2; PROTEIN LIN 25; PROTEIN SUR 2; RAS PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CELL FATE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; GENETIC TRANSCRIPTION; LEUKEMOGENESIS; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL NUCLEUS; CYTOSKELETAL PROTEINS; DNA, HELMINTH; DNA-BINDING PROTEINS; GREEN FLUORESCENT PROTEINS; HELMINTH PROTEINS; HOMEODOMAIN PROTEINS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION; WNT PROTEINS; ZEBRAFISH PROTEINS; ZINC FINGERS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; PROTOZOA;

EID: 0037099457     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.998402     Document Type: Article

References (55)

1. Plzf regulates limb and axial skeletal patterning
2. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch in the vulval induction pathway
3. TCF: Transcriptional activator or repressor?
4. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
5. The genetics of Caenorhabditis elegans
6. EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans
7. Wnt signaling: A common theme in animal development
8. Increasing complexity of Ras signaling
9. C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification
10. Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal
11. All in the family: The BTB/POZ, KRAB, and SCAN domains
12. Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development
13. The β-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
14. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways
15. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
16. Transcriptional activation modulated by homopolymeric glutamine and proline stretches
17. Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction
18. Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase
19. Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans
20. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans
21. Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1
22. Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein
23. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack
24. Molecular genetics of acute promyclocytic leukemia
25. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
26. Net (ERP/SAP2), one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif
27. A screen for mutations that prevent lethality caused by expression of activated sevenless and Ras1 in the Drosophila embryo
28. The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling
29. A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans
30. lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development
31. Dynamics and ultrastructure of developmental cell fusions in the Caenorhabditis elegans hypodermis
32. Structure and function of DNA-binding proteins
33. Caenorhabditis elegans lin-25: Cellular focus, protein expression and requirement for sur-2 during induction of vulval fates
34. Caenorhabditis elegans lin-25: A study of its role in multiple cell fate specification events involving Ras and the identification and characterization of evolutionarily conserved domains
35. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway
36. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway
37. A lin-45 raf enhancer sereen identifies eor-1, eor-2, and unusual alleles of Ras pathway genes in Caenorhabditis elegans
38. Lethal and amanitin-resistance mutations in the Caenorhabditis elegans ama-1 and ama-2 genes
39. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative pI9(ARF)-p53 signaling
40. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans
41. Receptor tyrosine kinases: Specific outcomes from general signals
42. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction
43. Genetics of RAS signaling in C. elegans
44. Transcription control by E1A and MAP kinase pathway via Sur2 Mediator subunit
45. MAP kinase signaling specificity mediated by the LIN-I Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction
46. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism
47. The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway
48. lin-25, a gene required for vulval induction in Caenorhabditis elegans
49. Protein interaction mapping in C. elegans using proteins involved in vulval development
50. The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans
51. Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation
52. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans
53. Signal transduction and the Ets family of transcription factors
54. Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene