A screen for mutations that prevent lethality caused by expression of activated sevenless and Ras1 in the Drosophila embryo

Developmental Genetics

Volumn 23, Issue 4, 1998, Pages 347-361

  Maixner, Andrew ^a,b   Hecker, Timothy P ^a,c   Phan, Quang N ^a   Wassarman, David A ^a,d  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c CATHOLIC UNIVERSITY OF AMERICA   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Embryogenesis; Eye development; Receptor tyrosine kinase; Signal transduction; Trithorax group

Indexed keywords

PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR;

ARTICLE; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MEMBRANE GLYCOPROTEINS; MUTATION; RAS PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 0032430747     PISSN: 0192253X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6408(1998)23:4<347::AID-DVG9>3.0.CO;2-C     Document Type: Article

References (78)

1. Allard JD, Chang HC, Herbst R, McNeill H, Simon MA. 1996. The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development 122:1137-1146.
2. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. 1990. Basic local alignment search tool. J Mol Biol 215:403-410.
3. Ashburner M. 1989a. Drosophila, A laboratory handbook. Cold Spring Harbor Press, Cold Spring Harbor.
4. Ashburner M. 1989b. Drosophila, A laboratory manual. Cold Spring Harbor Press, Cold Spring Harbor.
5. Banerjee U, Renfranz PJ, Pollock JA, Benzer S. 1987. Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye. Cell 49:281-291.
6. Basler K, Christen B, Hafen E. 1991. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64:1069-1081.
7. Basler K, Siegrist P, Hafen E. 1989. The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements. EMBO J 8:2381-2386.
8. Boguski MS, McCormick F. 1993. Proteins regulating Ras and its relatives. Nature 366:643-654.
9. Boube M, Benassayag C, Seroude L, Cribbs DL. 1997. Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity. Genetics 146:619-628.
10. Bowtell DD, Lila T, Michael WM, Hackett D, Rubin GM. 1991. Analysis of the enhancer element that controls expression of sevenless in the developing Drosophila eye. Proc Natl Acad Sci USA 88:6853-6857.
11. Bowtell DD, Simon MA, Rubin GM. 1988. Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster. Genes Dev 2:620-634.
12. Brunner D, Oellers N, Szabad J, Biggs WHR, Zipursky SL, Hafen E. 1994. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76:875-888.
13. Callahan CA, Bonkovsky JL, Scully AL, Thomas JB. 1996. derailed is required for muscle attachment site selection in Drosophila. Development 122:2761-2767.
14. Chang HC, Solomon NM, Wassarman DA, Karim FD, Therrien M, Rubin GM, Wolff T. 1995. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80:463-472.
15. Chang M, Jaehning JA. 1997. A multiplicity of mediators: alternative forms of transcription complexes communicate with transcriptional regulators. Nucleic Acids Res 25:4861-4865.
16. Clandinin TR, Katz WS, Sternberg PW. 1997. Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal. Dev Biol 182:150-161.
17. De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, Spierer P. 1996. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384:589-591.
18. Dickson BJ, Sprenger F, Morrison D, Hafen E. 1992. Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360:600-603.
19. Dickson BJ, Dominguez M, van der Straten A, Hafen E. 1995. Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80:453-462.
20. Dickson BJ, van der Straten A, Dominguez M, Hafen E. 1996. Mutations Modulating Raf signaling in Drosophila eye development. Genetics 142:163-171.
21. Farkas G, Gausz J, Galloni M, Reuter G, Gyurkovics H, Karch F. 1994. The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371:806-808.
22. Felsenfeld AL, Kennison JA. 1995. Positional signaling by hedgehog in Drosophila imaginal disc development. Development 121:1-10.
23. Fernandez R, Tabarini D, Azpiazu N, Frasch M, Schlessinger J. 1995. The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. EMBO J 14:3373-3384.
24. Fortini ME, Simon MA, Ruhin GM. 1992. Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355:559-561.
25. Gabay L, Seger R, Shilo BZ. 1997a. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277:1103-1106.
26. Gabay L, Seger R, Shilo BZ. 1997b. MAP kinase in situ activation atlas during Drosophila embryogenesis. Development 124:3535-3541.
27. Gellon G, Harding KW, McGinnis N, Martin MM, McGinnis W. 1997. A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. Development 124:3321-3331.
28. Gisselbrecht S, Skeath JB, Doe CQ, Michelson AM. 1996. heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev 10:3003-3017.
29. Greenwood S, Struhl G. 1997. Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos. Development 124:4879-4886.
30. Halder G, Callaerts P, Gehring WJ. 1995. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267:1788-1792.
31. Harding KW, Gellon G, McGinnis N, McGinnis W. 1995. A screen for modifiers of Deformed function in Drosophila. Genetics 140:1339-1352.
32. Heberlein U, Mlodzik M, Rubin GM. 1991. Cell-fate determination in the developing Drosophila eye: role of the rough gene. Development 112:703-712.
33. Kadonaga JT. 1998. Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines. Cell 92:307-313.
34. Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T, Rubin GM. 1996. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 143:315-329.
35. Kasten MM, Dorland S, Stillman DJ. 1997. A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol Cell Biol 17:4852-4858.
36. Kayne PS, Sternberg PW. 1995. Ras pathways in Caenorhabditis elegans. Curr Opin Genet Dev 5:38-43.
37. Kennison JA. 1995. The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet 29:289-303.
38. Kennison JA, Tamkun JW. 1988. Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc Natl Acad Sci USA 85:8136-8140.
39. Klämbt C, Glazer L, Shilo BZ. 1992. breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells. Genes Dev 6:1668-1678.
40. Klingler M, Erdelyi M, Szabad J, Nusslein-Volhard C. 1988. Function of torso in determining the terminal anlagen of the Drosophila embryo. Nature 335:275-277.
41. Lee H, Kraus KW, Wolfner MF, Lis JT. 1992. DNA sequence requirements for generating paused polymerase at the start of hsp70. Genes Dev 6:284-295.
42. Mayer-Jaekel RE, Ohkura H, Gomes R, Sunkel CE, Baumgartner S, Hemmings BA, Glover DM. 1993. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell 72:621-633.
43. Mortin MA, Zuerner R, Berger S, Hamilton BJ. 1992. Mutations in the second-largest subunit of Drosophila RNA polymerase II interact with Ubx. Genetics 131:895-903.
44. Mullins MC, Rubin GM. 1991. Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action. Proc Natl Acad Sci USA 88:9387-9391.
45. Mumby MC, Walter G. 1993. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Physiol Rev 73:673-699.
46. Neufeld TP, Tang AH, Rubin GM. 1998. A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. Genetics 148:277-286.
47. Neuman-Silberberg FS, Schejter E, Hoffmann FM, Shilo BZ. 1984. The Drosophila ras oncogenes: structure and nucleotide sequence. Cell 37:1027-1033.
48. Noselli S. 1998. JNK signaling and morphogenesis in Drosophila. Trends Genet 14:33-38.
49. O'Neill EM, Rebay I, Tjian R, Rubin GM. 1994. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78:137-147.
50. Pazin MJ, Kadonaga JT. 1997. What's up and down with histone deacetylation and transcription? Cell 89:325-328.
51. Perrimon N. 1994. Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr Opin Cell Biol 6:260-266.
52. Queenan AM, Ghabrial A, Schüpbach T. 1997. Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124:3871-3880.
53. Rebay I, Rubin GM. 1995. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81:857-866.
54. Reichman-Fried M, Dickson B, Hafen E, Shilo BZ. 1994. Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev 8:428-439.
55. Roeder RG. 1996. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci 21:327-335.
56. Samakovlis C, Hacohen N, Manning G, Sutherland DC, Guillemin K, Krasnow MA. 1996. Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development 122:1395-1407.
57. Sauer F, Wassarman DA, Rubin GM, Tjian R. 1996. TAF(II)s mediate activation of transcription in the Drosophila embryo. Cell 87:1271-1284.
58. Simon J. 1995. Locking in stable states of gene expression: transcriptional controlling during Drosophila development. Curr Opin Cell Biol 7:376-385.
59. Simon MA, Bowtell DD, Dodson GS, Laverty T, Rubin GM. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67:701-716.
60. Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ Jr, Backer JM, Ullrich A, White MF, et al. 1993. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12:1929-1936.
61. Spradling AC, Stern DM, Kiss I, Roote J, Laverty T, Rubin GM. 1995. Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci USA 92:10824-10830.
62. Struhl K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev 12:599-606.
63. Sutherland D, Samakovlis C, Krasnow MA. 1996. branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87:1091-1101.
64. Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM. 1995. KSR, a novel protein kinase required for RAS signal transduction. Cell 83:879-888.
65. Tomlinson A, Bowtell DD, Hafen E, Rubin GM. 1987. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell 51:143-150.
66. Tomlinson A, Ready DF. 1986. Sevenless: a cell-specific homeotic mutation of the Drosophila. Cell 231:400-402.
67. Uemura T, Shiomi K, Togashi S, Takeichi M. 1993. Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila maginal discs. Genes Dev 7:429-440.
68. van Zyl W, Huang W, Sneddon AA, Stark M, Camier S, Werner M, Marck C, Sentenac A, Broach JR. 1992. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae. Mol Cell Biol 12:4946-4959.
69. Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S. 1996. Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics 144:1127-1141.
70. Vidal M, Gaber RF. 1991. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol 11:6317-6327.
71. Vidal M, Strich R, Esposito RE, Gaber RF. 1991. RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes. Mol Cell Biol 11:6306-6316.
72. Walter G, Mumby M. 1993. Protein serine/threonine phosphatases and cell transformation. Biochim Biophys Acta 1155:207-226.
73. Waskiewicz AJ, Cooper JA. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol 7:798-805.
74. Wassarman DA, Solomon NM, Chang HC, Karim FD, Therrien M, Rubin GM. 1996. Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila. Genes Dev 10:272-278.
75. Wassarman DA, Therrien M. 1997. Ras1-mediated photoreceptor development in Drosophila. Adv Dev Biol 5:1-41.
76. Wolffe AP, Wong J, Pruss D. 1997. Activators and repressors: making use of chromatin to regulate transcription. Genes Cells 2:291-302.
77. Wu C. 1997. Chromatin remodeling and the control of gene expression. J Biol Chem 272:28171-28174.
78. Zeidler MP, Yokomori K, Tjian R, Mlodzik M. 1996. Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. Genes Dev 10:50-59.