An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia

Biological Psychiatry

Volumn 51, Issue 10, 2002, Pages 788-794

  Ritsner, Michael ^a   Modai, Ilan ^a,b   Ziv, Hana ^c,d   Amir, Sharon ^c   Halperin, Tami ^c,d   Weizman, Abraham ^c,e,f   Navon, Ruth ^c,d  

^a SHA'AR MENASHE MENTAL HEALTH CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d MEIR MEDICAL CENTER   (Israel)

^e GEHA MENTAL HEALTH CENTER   (Israel)

^f RABIN MEDICAL CENTER   (Israel)

Author keywords

Association; CAG repeat length; KCNN3 gene; Potassium channel; Schizophrenia; Symptom dimensions

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; FAMILY; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; JEW; KCNN3 GENE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS OF VARIANCE; NEGATIVE SYNDROME; PARANOIA; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADOLESCENT; ADULT; AGED; BLOTTING, SOUTHERN; DNA PRIMERS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; TRINUCLEOTIDE REPEATS;

EID: 0037093780     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(01)01348-8     Document Type: Article

References (48)

1. Symptoms of schizophrenia: Methods, meanings, and mechanisms
2. Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21
3. Mapping of hKCa3 to chromosome 1q21 and investigation of linkage of CAG repeat polymorphism to schizophrenia
4. No evidence for involvement of KCNN3 (hSKCa3) potassium channel gene in familial and isolated cases of schizophrenia
5. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
6. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation
7. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22
8. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia
9. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: A candidate for schizophrenia and bipolar disorder?
10. Lack of association between schizophrenia and a CAG repeat polymorphism of the hSKCa3 gene in a north eastern US sample
11. A critical overview of recent investigations into the genetics of schizophrenia
12. Age at onset of schizophrenia and neuroleptic dosage
13. Symptom structure in schizophrenia: Two-, three- or four-factor models?
14. HKCa3/KCNN3 potassium channel gene: Association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21
15. Transcriptional activation modulated by homopolymeric glutamine and proline stretches
16. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences
17. No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar disorder in the Irish population
18. Relationship of neuropsychological and MRI measures to age of onset of schizophrenia
19. Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia
20. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
21. CAG repeats in cDNA from human brain
22. Prepulse inhibition of the startle response in men with schizophrenia: Effects of age of onset of illness, symptoms, and medication
23. Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia
24. Five-factor model of schizophrenia: Initial validation
25. Hemispheric asymmetry of frontal and temporal gray matter and age of onset in schizophrenia
26. The genetics of schizophrenia
27. CDNAs with long CAG trinucleotide repeats from human brain
28. Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia
29. Factor structure and clinical validity of competing models of positive symptoms in schizophrenia
30. Glutamine repeats and inherited neurodegenerative disease: Molecular aspects
31. Differences in quality of life domains, psychopathologic and psychosocial factors in psychiatric patients
32. HSKCa3: No association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia
33. Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia
34. Variation at the MJD locus in the major psychoses
35. Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images
36. Short CAG repeats within the hSKCa3 gene associated with schizophrenia: Results of a family-based study
37. HKCNN3 which maps to chromosome 1q21 is not the causative gene in periodic catatonia, a familial subtype of schizophrenia
38. Age at onset and outcome in schizophrenia are related to the degree of familial loading
39. Genetic association study of a polymorphic CAG repeats array of calcium-activated potassium channel (KCNNE) gene and schizophrenia among the Chinese population from Taiwan
40. Schizophrenia: A review of genetic studies
41. Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder
42. The unstable trinucleotide repeat story of major psychosis
43. The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3, and shows a possible association with schizophrenia
44. Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons