Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia

Molecular Psychiatry

Volumn 3, Issue 3, 1998, Pages 266-269

  Bowen, T ^a   Guy, C A ^a   Craddock, N ^b   Cardno, A G ^a   Williams, N M ^a   Spurlock, G ^a   Murphy, K C ^a   Jones, L A ^a   Gray, M ^a   Sanders, R D ^a   McCarthy, G ^a   Chandy, K G ^c   Fantino, E ^c   Kalman, K ^c   Gutman, G A ^d   Gargus, J J ^c   Williams, J ^a   McGuffin, P ^a   Owen, M J ^a   O'Donovan, M C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Association; Potassium channels; Schizophrenia; Trinucleotide repeats

Indexed keywords

GLUTAMIC ACID; POTASSIUM CHANNEL;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; TRINUCLEOTIDE REPEAT;

EID: 7144262383     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000400     Document Type: Article

References (15)

1. Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong Li-Li, Ho T-H et al. Isolation of a novel potassium channel gene, hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry 1998; 3: 32-37.
2. Schalling M, Hudson TJ, Buetow KH, Housman DE. Direct detection of novel expanded trinucleotide repeats in the human genome. Nat Genet 1993; 4: 135-139.
3. Lindblad K, Nylander P-O, De Bruyn A, Sourey D, Zander C, Engstrom C et al. Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method. Neurobiol Dis 1995; 2: 55-62.
4. Morris AG, Gaitonde E, McKenna PJ, Mollon JD, Hunt DM. CAG repeat expansions and schizophrenia: association with disease in females and with early age-at-onset. Hum Molec Genet 1995; 4: 1957-1961.
5. O'Donovan MC, Guy C, Craddock N, Murphy KC, Cardno AG, Jones LA et al. Expanded CAG repeats in schizophrenia and bipolar disorder. Nat Genet 1995; 10: 380-381.
6. O'Donovan MC, Guy C, Craddock N, Bowen T, McKeon P, Macedo A et al. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychol Med 1996; 26: 1145-1153.
7. Oruc L, Lindblad K, Verheyen GR, Ahlberg S, Jakovljevic M, Ivezic S et al. CAG repeat expansions in bipolar and unipolar disorders. Am J Hum Genet 1997; 60: 730-732.
8. 1A-voltage-dependent calcium channel. Nat Genet 1997; 15: 62-69.
9. McGuffin P, Farmer A, Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psych 1991; 48: 764-770.
10. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R et al. SCAN: Schedules for clinical assessment in neuropsychiatry. Arch Gen Psych 1990; 47: 589-593.
11. Wing JK, Cooper JE, Sartorius N. Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge, 1972.
12. Owen MJ, Holmans P, McGuffin P. Association study in psychiatric genetics. Mol Psychiatry 1997; 2: 270-273.
13. Gastier JM, Brody T, Pulido JC, Businga T, Sunden S, Hu X et al. Development of a screening set for now (CAG/CTG)n dynamic mutations. Genomics 1996; 32: 74-85.
14. Pulst S-M, Nechiporuk A, Nechiporuk T, Gispert S, Chen XN, Lopescendes I et al. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type-2. Nature Genet 1996; 14: 269-276.
15. Bowen T, Guy C, Speight G, Jones L, Cardno A, Murphy K et al. Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using RED and a PCR screening set. Am J Hum Genet 1996; 59: 912-917.