Prepulse inhibition of the startle response in men with schizophrenia: Effects of age of onset of illness, symptoms, and medication

Archives of General Psychiatry

Volumn 57, Issue 6, 2000, Pages 609-614

  Kumari, Veena ^a   Soni, William ^a   Mathew, Vallakalil M ^a   Sharma, Tonmoy ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; HUMAN; MALE; ONSET AGE; PREPULSE INHIBITION; SCHIZOPHRENIA; STARTLE REFLEX;

EID: 0034085394     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.57.6.609     Document Type: Article

References (43)

1. Graham FK. The more or less startling effects of weak prestimuli. Psychophysiology. 1975;12:238-248.
2. Hoffman HS, Ison JR. Reflex modification in the domain of startle, 1: some empirical findings and their interpretations for how the nervous system processes sensory input. Psychol Rev. 1980;87:175-189.
3. Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Bull. 1993;19:233-259.
4. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 1978;15: 339-343.
5. Braff DL, Grillon C, Geyer MA. Gating and habitation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry. 1992;49:206-215.
6. Grillon C, Ameli R, Charney DS, Krystal JH, Braff DL. Startle gating deficit occurs across prepulse intensities in schizophrenic patients. Biol Psychiatry. 1992; 32:929-943.
7. Dawson ME, Hezlett EA, Filion DL, Nuechterlein KH, Schell AM. Attention and schizophrenia: impaired modulation of the startle reflex. J Abnorm Psychol. 1993; 102:633-641.
8. Dawson ME, Schell AM, Swerdlow NE, Filion DL. Cognitive, clinical, and neuropsychological implications of startle modulation. In: Lang PJ, Simons RF, Balaban M, eds. Attention and Orienting: Sensory and Motivational Processes. Mahwah. NJ: Lawrence A Erlbaum Inc; 1997.
9. Faraone SV, Chen WJ, Golstein JM, Tsuang MT. Gender differences in age at onset of schizophrenia. Br J Psychiatry. 1994;164:625-629.
10. Castle DJ, Murray RM. The neurodevelopmental basis of sex differences in schizophrenia. Psychol Med. 1991;21:565-575.
11. Bartzokis G, Nuechterlein KH, Marder SR, Mintz J, Dery K, Laack K. Age at illness onset and left temporal lobe length in males with schizophrenia. Psychiatry Res. 1996;67:189-201.
12. Johnstone EC, Owens DG, Bydder GM, Colter N, Crow TJ, Frith CD. The spectrum of structural changes in schizophrenia: age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates. Psychol Med. 1989;19:91-103.
13. Doering S, Muller E, Kopcke W, Pietzcker A, Gaebel W, Linden M, Muller P, Muller-Spahn F, Tegeler J, Schussler G. Predictors of relapse and rehospitalization in schizophrenia and schizoaffective disorder. Schizophr Bull. 1998;24:87-98.
14. Meltzer HY, Rabinowitz J, Lee MA, Cola PA, Ranjan R, Findling RL, Thompson PA. Age at onset and gender of schizophrenics in relation to neuroleptic resistance. Am J Psychiatry. 1997;154:475-482.
15. Lewine R, Haden C, Caudle J, Shurett R. Sex-onset effects on neuropsychological function in schizophrenia. Schizophr Bull. 1997;23:51-61.
16. Braff DL, Perry W, Cadenhead KS, Swerdlow NR, Geyer MA. Prepulse inhibitory deficits in schizophrenia: gender effects [abstract]. Biol Psychiatry. 1995;37:654.
17. Feinberg I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res. 1982-1983;17:319-334.
18. Jernigan TL, Zisook S, Heaton RK, Moranville JT, Hesselink JR, Braff DL. Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch Gen Psychiatry. 1991;48:881-890.
19. Braff DL, Geyer MA. Sensorimotor gating and schizophrenia: human and animal model studies. Arch Gen Psychiatry. 1990;47:181-188.
20. Perry W, Braff DL. Information processing deficits and thought disorder in schizophrenia. Am J Psychiatry. 1994;151:363-367.
21. Perry W, Geyer MA, Braff DL. Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients. Arch Gen Psychiatry. 1999;56:277-281.
22. Bratf DL, Butler RW, Jenkins MJ, Geyer MA. Wisconsin card sorting in schizophrenia: neurophysiological correlates [abstract]. Proc Am Coll Neuropsychopharmacol. 1989;28:42.
23. Butler RW, Jenkins MA, Geyer MA, Braff DL. Wisconsin Card Sorting deficits and diminished sensorimotor gating in a discrete subgroup of subjects, In: Tamminga CA, Schulz SC, eds. Schizophrenia Research: Advances in Neuropsychiatry and Psychopharmacology, Vol 1. New York, NY: Raven Press; 1991.
24. Karper LP, Freeman GK, Grillon C, Morgan CA III, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractability in psychosis. J Neuropsychiatr Clin Neurosci. 1996;8:60-66.
25. Kumari V, Soni W, Sharma T. Normalization of information processing deficits in schizophrenia with clozapine. Am J Psychiatry. 1999;156:1046-1051.
26. Braff DL, Swerdlow NR, Geyer MA. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. Am J Psychiatry. 1999;156:596-602.
27. Swerdlow NR, Geyer MA. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull. 1998;24:285-301.
28. Hamm A, Weike A, Bauer U, Valti D, Gallhofer B. Prepulse inhibition in medicated and unmedicated patients [abstract]. Psychophysiology. 1995;32(suppl 1):S38.
29. Wu CJ, Potkin SG, Ploszaj DI, Lau V, Telford J, Richmond G. Clozapine improves sensory gating more than haldol [abstract]. Presented at: the 145th Annual Meeting of the American Psychiatric Association; May 6, 1992; Washington, DC.
30. Swerdlow MR, Auerbach A, Monroe SM, Hartson H, Geyer MA, Braff DL. Men are more inhibited than women by weak prepulses. Biol Psychiatry. 1992;34; 253-260.
31. Swerdlow MR, Hartson H, Auerbach A. Changes in sensorimotor inhibition across the menstrual cycle: implications for neuropsychiatric disorders. Biol Psychiatry. 1997;41:452-460.
32. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-P), Version 2. New York, NY: New York State Psychiatric Institute, Biometrics Research; 1995.
33. Kay SR, Fishbein A, Olper LA. The positive and negative syndrome scale. Schizophr Bull. 1987;13:261-276.
34. Kendler KS, Tsuang MT, Hays P. Age at onset in schizophrenia: a familial perspective. Arch Gen Psychiatry. 1987;44:881-890.
35. Mansbach RS, Geyer MA, Braff DL. Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology. 1988;94:507-514.
36. Sham PC, Jones P, Russell A, Gilvarry K, Bebbington P, Lewis S, Toone B, Murray R, for the Camberwell Collaborative Psychosis Study. Age of onset, sex, and psychiatric morbidity in schizophrenia. Br J Psychiatry. 1994;165:466-473.
37. Verdoux H, Geddes JR, Takei N, Lawrie S, Bovet P, Eagles JM, Heun R, McCreadie RG, McNeil TF, O'Callaghan E, Stober G, Willinger MG, Wright P, Murray R. Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data. Am J Psychiatry. 1997;154:1220-1227.
38. Murray R, O'Callagham E, Castle DJ, Lewis SW. A neurodevelopmental approach to the classification of schizophrenia. Schizophr Bull. 1992;2:319-332.
39. Meltzer HY. Dimensions of outcome with clozapine. Br J Psychiatry Suppl. May 1992:46-53.
40. Zipursky RB, Zhang-Wong J, Lambe EK, Bean G, Beiser M. MRI correlates of treatment response in first episode psychosis. Schizophr Res. 1998;30:81-90.
41. Smith GN, Kopala LC, Lapointe JS, MacEwan GW, Altman S, Flynn SW, Schneider T, Falkai P, Honer WG. Obstetric complications, treatment response and brain morphology in adult-onset and early-onset males with schizophrenia. Psychol Med. 1998;28:645-653.
42. Hazlett EA, Buchsbaumm MS, Haznedar MM, Singer MB, Germans MK, Schnur DB, Jimenez EA, Buchsbaum BR, Troyer BT. Prefrontal cortex glucose metabolism and startle eyeblink modification abnormalities in unmedicated schizophrenia patients. Psychophysiology. 1998;35:186-198.
43. Ford JM, Roth WT, Memon V, Pfefferbaum A. Failures of automatic and strategic processing in schizophrenia: comparisons of event-related brain potentials and startle blink modulation. Schizophr Res. 1999;37:149-163.