Nuclear Localization and Dominant-negative Suppression by a Mutant SKCa3 N-terminal Channel Fragment Identified in a Patient with Schizophrenia

Journal of Biological Chemistry

Volumn 276, Issue 30, 2001, Pages 27753-27756

  Miller, Mark J ^a   Rauer, Heiko ^a,c   Tomita, Hiroaki ^a   Rauer, Heike ^a,d   Gargus, J Jay ^a   Gutman, George A ^b   Cahalan, Michael D ^a   Chandy, K George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c 4SC AG   (Germany)

^d NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; MICROSCOPIC EXAMINATION; PATIENT TREATMENT; POLYPEPTIDES; PROTEINS;

CONFOCAL MICROSCOPY;

BIOMEDICAL ENGINEERING;

CALCIUM ACTIVATED POTASSIUM CHANNEL; GREEN FLUORESCENT PROTEIN; IKCA1 POLYPEPTIDE; POLYGLUTAMINE; POLYPEPTIDE; PROTEIN SUBUNIT; SKCA2 POLYPEPTIDE; SKCA3 POLYPEPTIDE; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; HYBRID PROTEIN; KCNN3 PROTEIN, HUMAN; PEPTIDE; PHOTOPROTEIN; POTASSIUM CHANNEL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; CHROMOSOME 1Q; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRIC POTENTIAL; GENE; GENE DELETION; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MAMMAL CELL; NERVE CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN TARGETING; SCHIZOPHRENIA; SKCA3 GENE; SPIKE; ALLELE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL NUCLEUS; CELL STRAIN COS1; CHEMISTRY; DOMINANT GENE; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; MOUSE; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MAMMALIA;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; COS CELLS; DNA, COMPLEMENTARY; ELECTROPHYSIOLOGY; GENE DELETION; GENES, DOMINANT; GREEN FLUORESCENT PROTEINS; HUMANS; JURKAT CELLS; LUMINESCENT PROTEINS; MICE; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RECOMBINANT FUSION PROTEINS; SCHIZOPHRENIA; SEQUENCE HOMOLOGY, AMINO ACID; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; TRANSFECTION;

EID: 0035958882     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100221200     Document Type: Article

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