Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 4, 1999, Pages 348-351

  Antonarakis, Stylianos E ^a,f   Blouin, Jean Louis ^a   Lasseter, Virginia K ^b   Gehrig, Corinne ^a   Radhakrishna, Uppala ^a   Nestadt, Gerry ^b   Housman, David E ^c   Kazazian, Haig H ^d   Kalman, Katalin ^e   Gutman, George ^e   Fantino, Emmanuel ^e   Chandy, K George ^e   Gargus, J Jay ^e   Pulver, Ann E ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Chromosome I; Linkage analysis; Schizophrenia; Trinucleotide repeats

Indexed keywords

ARTICLE; CHROMOSOME 1Q; CONTROLLED STUDY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHIZOPHRENIA; TRINUCLEOTIDE REPEAT;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; POLYMORPHISM, GENETIC; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; SCHIZOPHRENIA; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; TRINUCLEOTIDE REPEATS;

EID: 0033588335     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990820)88:4<348::AID-AJMG11>3.0.CO;2-N     Document Type: Article

References (17)

1. American Psychiatrie Association (APA). 1994. Diagnostic and statistical manual of mental disorders, 4th ed. Washington, D.C.: American Psychiatric Association.
2. Blouin JL, Christie DH, Gos A, Lynn A, Morris MA, Ledbetter DH, Chakravarti A, Antonarakis SE. 1995. A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. Amer J Hum Genet 57:388-394.
3. Blouin J-L, Dombroski B, Swapan K, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Gehrig C, Radhakrishna U, Snyder S, Balk KG, Neufel K, Demarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman D, Kazazian HH, Antonarakis SE, Pulver AE. 1998. Multigenic inheritance of schizophrenia: A genome scan identifies susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20:70-73.
4. Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong L-L, Ho T-H, Gutman GA, Crocq M-A, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ. 1998. Isolation of a novel potassium channel gene KCNN3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatr 3:32-37.
5. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Kazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J. 1996. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152-154.
6. Ewens WJ, Spielman RS. 1995. The transmission/disequilibrium test: History, subdivision, and admixture. Am J Hum Genet 57:455-464.
7. Pulver AE, Bale SJ. 1989. Availability of schizophrenic patients and their families for genetic linkage studies: findings from the Maryland Epidemiology Sample. Genet Epidemiol 6:671-680.
8. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, et al. 1994. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet 54:36-43.
9. Pulver AE, Lasseter VK, Kasch L, Wolyniee P, Nestadt G, Blouin J-L, Kimberland M, Babb R, Vourlis S, Chen H, et al. 1995. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60:252-260.
10. Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, et al. 1996. The Johns Hopkins University Collaborative Schizophrenia Study: an epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. The Cold Spring Harbor Symp. Quant. Biol. Symposium 61. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, p 797-814.
11. Rao DC, Morton NE, Gottesman II, Lew R. 1981. Path analysis of qualitative data on pairs of relatives: Application to schizophrenia. Hum Hered 31:325-333.
12. Schaffer AA. 1996. Faster linkage analysis computations for pedigrees with loops or unused alleles. Hum Hered 46:226-235.
13. Schwab SG, Eckstein GN, Hallmayer J, Lerer B, Albus M, Borrmann M, Lichtermann D, Ertl MA, Maier W, Wildenauer DB. 1997. Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Mol Psychiatr 2:156-160.
14. Sheffield VC, Weber JL, Buetow KH, Murray JC, Even DA, Wiles K, Gastier JM, Pulido JC, Yandava C, Sunden SL, et al. 1995. A collection of tri- and tetranucleotide repeat markers used to generate high quality, high resolution human genome-wide linkage maps. Hum Mol Genet 4:1837-1844.
15. Straub RE, MacLean CJ, O'Neill FA, Walsh D, Kendler KS. 1997. Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatr 2:148-155.
16. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D. 1996. A potential vulnerability locus for schizophrenia on chromosome 6p24-26: evidence for genetic heterogeneity. Nat Genet 11:287-293.
17. Terwilliger JD. 1995. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56:777-787.