Areas of demyelination do not attract significant numbers of Schwann cells transplanted into normal white matter

GLIA

Volumn 31, Issue 3, 2000, Pages 232-240

  Iwashita, Yasushi ^a,b,c   Blakemore, William F ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell migration; Demyelination; Remyelination; Schwann cell; Transplantation

Indexed keywords

ANIMAL; ARTICLE; CELL COUNT; CELL CULTURE; DEMYELINATING DISEASE; METABOLISM; MYELINATED NERVE; NERVE DEGENERATION; NERVE FIBER TRANSECTION; PATHOLOGY; PATHOPHYSIOLOGY; RAT; RAT STRAIN; SCHWANN CELL; SPINAL CORD; TRANSPLANTATION; ULTRASTRUCTURE;

ANIMALS; AXOTOMY; CELL COUNT; CELLS, CULTURED; DEMYELINATING DISEASES; NERVE FIBERS, MYELINATED; RATS; RATS, INBRED STRAINS; SCHWANN CELLS; SPINAL CORD; WALLERIAN DEGENERATION;

EID: 0033828707     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-1136(200009)31:3<232::AID-GLIA40>3.0.CO;2-8     Document Type: Article

References (31)

1. Cell-cell interactions during the migration of myelin-forming cells transplanted in the demyelinated spinal cord
2. Pathways of migration of transplanted Schwann cells in the demyelinated mouse spinal cord
3. Invasion of Schwann cells into the spinal cord of the rat after local injections of lysolecithin
4. Ethidium bromide induced demyelination in the spinal cord of the cat
5. Remyelination of demyelinated spinal cord axons by Schwann cells
6. Limited remyelination of CNS axons by Schwann cells transplanted into the sub-arachnoid space
7. The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system
8. Transplantation of glial cells into areas of demyelination in the adult rat spinal cord
9. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve
10. Interrelationship between Schwann cell function and extracellular matrix production
11. GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors
12. Observations on the migratory behaviour of Schwann cells from adult peripheral nerve in explant culture
13. Structure and behaviour of rat primary and secondary Schwann cells in vitro
14. Schwann cell invasion of the central nervous system of myelin mutants
15. Transplanted CG4 cells (an oligodendrocyte progenitor cell lime) survive, migrate and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord, but not in normal spinal cord
16. Requirements for Schwann cell migration within CNS environments: A viewpoint
17. Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system
18. Autoradiographic and ultrastructural studies of areas of spinal cord occupied by Schwann cells and Schwann cell myelin
19. Proliferation of rat intraspinal Schwann cells after tellurium intoxication
20. Schwann cell and oligodendrocyte remyelination in lysolecithin-induced lesions in irradiated rat spinal cord
21. Schwann cells divide in a demyelinating lesion of the central nervous system
22. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells
23. Schwann cell remyelination of demyelinated axons in spinal cord multiple sclerosis lesions
24. Redistribution of bisbenzimide Hoechst 33342 from transplanted cells to host cells
25. Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival
26. Myelin repair by Schwann cells in the regenerating goldfish visual pathway: Regional patterns revealed by X-irradiation
27. Oligodendrocyte precursors survive poorly and do not migrate after transplantation into the normal adult central nervous system
28. Remyelination occurs as extensively but more slowly in old rats compared to young rats after gliotoxin-induced CNS demyelination
29. Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated rat brain
30. Evidence that sensory axons are mitogenic for Schwann cells
31. Demyelination and remyelination of the caudal cerebellar peduncle of adult rats after stereotaxic injection of lysolecithin, ethidium bromide and complement/anti-galactocerebroside - A comparative study