Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord

Experimental Neurology

Volumn 167, Issue 1, 2001, Pages 27-39

  Akiyama, Yukinori ^a   Honmou, Osamu ^a,b,c   Kato, Takaaki ^a   Uede, Teiji ^a   Hashi, Kazuo ^a   Kocsis, Jeffery D ^b,c  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Axon; Demyelination; Glia; Multiple sclerosis; Myelin; Neural precursor cells; Schwann cell

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; MITOGENIC AGENT; MYELIN; NESTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DEMYELINATION; DENTATE NUCLEUS; GLIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LATERAL BRAIN VENTRICLE; MULTIPLE SCLEROSIS; MYELINATION; NERVE CELL; NERVE CELL CULTURE; NERVE CONDUCTION; NERVE FIBER; NEUROEPITHELIUM; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; SCHWANN CELL; STEM CELL;

EID: 0035152429     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7539     Document Type: Article

References (56)

1. Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
2. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
3. Morphology of normal peripheral axons
4. The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system
5. Suppression of remyelination in the CNS by X-irradiation
6. Host-guided migration allows targeted introduction of neurons into the embryonic brain
7. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
8. Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
9. Cell fate determination in the vertebrate retina
10. In vitro propagation and inducible differentiation of multipotential progenitor cells from human fetal brain
11. Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis
12. Olfactory ensheathing cells do not require L-ascorbic acid in vitro to assemble a basal lamina or to myelinate dorsal root ganglion neurites
13. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
14. Conduction properties of central nerve fibers remyelinated by Schwann cells
15. Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS
16. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain
17. Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro
18. Learning enhances adult neurogenesis in the hippocampal formation
19. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor
20. Myelination following transplantation of EGF-responsive neural stem cells into a myelin-deficient environment
21. Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: Role of macrophages
22. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells
23. Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelihated dorsal columns of the rat spinal cord
24. The Schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves
25. Identification of a neural stem cell in the adult mammalian central nervous system
26. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
27. Neuroepithelial stem cells from the embryonic spinal cord: Isolation, characterization, and clonal analysis
28. Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation
29. Absence of potassium conductance in central myelinated axons
30. Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain
31. Glial cell lineages in the neural crest
32. Interleukin-1 regulates synthesis of nerve growth factor in nonneuronal cells of rat sciatic nerve
33. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia
34. Long-distance neuronal migration in the adult mammalian brain
35. Host regulation of glial markers in intrastriatal grafts of conditionally immortalized neural stem cell lines
36. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
37. Isolation and transplantation of multipotential populations of epidermal growth factor-responsive neural progenitor cells from the canine brain
38. Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells
39. Culture, expansion, and transplantation of human fetal neural progenitor cells
40. A common neural progenitor for the CNS and PNS
41. Neural stem cells
42. The adult rat hippocampus contains primordial neural stem cells
43. Tropism in nerve regeneration in vivo. Attraction of regenerating axons by diffusible factors derived from cells in distal nerve stumps of transected peripheral nerves
44. FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells
45. Immortalization and controlled in vitro differentiation of murine multipotent neural crest stem cells
46. A tripotential glial precursor cell is present in the developing spinal cord
47. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain
48. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
49. The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line
50. Multipotent neural progenitors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex
51. Isolation of a stem cell for neurons and glia from the mammalian neural crest
52. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease
53. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system
54. Cerebellar precursors transplanted to the neonatal dentate gyrus express features characteristic of hippocampal neurons
55. Target size regulates calibre and myelination of sympathetic axons
56. Generation of oligodendroglial progenitors from neural stem cells