Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival

Experimental Neurology

Volumn 164, Issue 2, 2000, Pages 292-302

  Iwashita, Yasushi ^a,b,c   Fawcett, James W ^a,b   Crang, A J ^a   Franklin, Robin J M ^a   Blakemore, William F ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell migration; Cell survival; Demyelination; LacZ; Remyelination; Schwann cell; Transplantation; X irradiation

Indexed keywords

FORSKOLIN;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; DEMYELINATION; FEMALE; GLIA CELL; MYELIN SHEATH; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; SCHWANN CELL; STEM CELL; WHITE MATTER; X IRRADIATION;

EID: 0034535243     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7440     Document Type: Article

References (59)

1. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
2. In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature-sensitive mutant gene of the SV40 large T antigen
3. Cell-cell interactions during the migration of myelin-forming cells transplanted in the demyelinated spinal cord
4. The fate of Schwann cells transplanted in the brain during development
5. Pathways of migration of transplanted Schwann cells in the demyelinated mouse spinal cord
6. Hoechst 33342 a suitable fluorescent marker for Schwann cells after transplantation in the mouse spinal cord
7. Repair of a myelin lesion by Schwann cells transplanted in the adult mouse spinal cord
8. Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat
9. Invasion of Schwann cells into the spinal cord of the rat following local injections of lysolecithin
10. Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerve
11. The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system
12. Extensive oligodendrocyte remyelination following injection of cultured central nervous system cells into demyelinating lesions in adult central nervous system
13. Transplantation of glial cells into areas of demyelination in the adult rat spinal cord
14. Suppression of remyelination in the CNS by X-irradiation
15. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve
16. Morphology and migration of cultured Schwann cells transplanted into the fimbria and hippocampus in adult rats
17. Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination
18. The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals
19. GAP-43 is expressed by nonmyelin-forming Schwann cells of the peripheral nervous system
20. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors
21. Transplantation of rat Schwann cells grown in tissue culture into the mouse spinal cord
22. A model of chronic spinal cord compression in the cat
23. The electron microscopic appearance of the beta-galactosidase reaction product
24. Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord but not in normal spinal cord
25. Requirements for Schwann cell migration within CNS environments: A view-point
26. Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS
27. Astrocyte-Schwann cell interactions in culture
28. Glial-glial and glial-neuronal interfaces in radiation-induced, gila-depleted spinal cord
29. Delayed remyelination in rat spinal cord following ethidium bromide injection
30. Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells
31. Labeling and identifying grafted cells
32. Distinctive patterns of PDGF-A, FGF-2, IGF-I, and TGF-1 gene expression during remyelination of experimentally-induced spinal cord demyelination
33. Cervical spondylotic myelopathy. Clinicopathologic study on the progression pattern and thin myelinated fibers of the lesions of seven patients examined during complete autopsy
34. Redistribution of bisbenzimide Hoechst 33342 from transplanted cells to host cells
35. The Schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves
36. Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: Development and regulation by neuron-Schwann Cell interactions
37. Resolution of the pathway taken by implanted Schwann cells to a spinal cord lesion by prior infection with a retrovirus encoding beta-galactosidase
38. The use of cell lines in neurobiology
39. Chronically denervated rat Schwann cells respond to GGF in vitro
40. Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord
41. Integration of transplanted cultured Schwann cells into the long myelinated fiber tracts of the adult spinal cord
42. Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB
43. Multiple essential functions of neuregulin in development
44. The effects of cAMP on differentiation of cultured Schwann cells: Progression from an early phenotype (04+ to a myelin phenotype (PO+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition
45. Oligodendrocyte precursors survive poorly and do not migrate following transplantation into the normal adult central nervous system
46. The effect of injection technique on the passive spread of astrocytes following transplantation into rat spinal cord white matter
47. In vitro labeling strategies for identifying primary neural tissue and a neuronal cell line after transplantation in the CNS
48. Release of autocrine growth factor by primary and immortalized Schwann cells
49. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer
50. Schwann cells transplanted into the CNS
51. Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants
52. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
53. Polysialic acid in the vertebrate nervous system: A promoter of plasticity in cell-cell interactions
54. Evidence that secondary rat Schwann cells in culture maintain their differentiated phenotype
55. Long-term tracing of vital neurons with Hoechst 33342 in transplantation studies
56. Lines of glial precursor cells immortalized with a temperature-sensitive oncogene give rise to astrocytes and oligodendrocytes following transplantation into demyelinated lesions in the central nervous system
57. Grafts of genetically modified Schwann cells to the spinal cord: Survival, axon growth, and myelination
58. The fate of Schwann cells isolated from axonal contact
59. N-Cadherin inhibits Schwann cell migration on astrocytes