Transplanted glial cells migrate over a greater distance and remyelinate demyelinated lesions more rapidly than endogenous remyelinating cells

Journal of Neuroscience Research

Volumn 61, Issue 3, 2000, Pages 288-294

  Blakemore, W F ^a   Gilson, J M ^a   Crang, A J ^a  

^a Department of Clinical Veterinary Medicine ^*  (United Kingdom)

Author keywords

Migration; Oligodendrocyte progenitors; Remyelination; Transplantation

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL TRANSPLANTATION; DEMYELINATING DISEASE; GLIA CELL; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; STEM CELL; X IRRADIATION;

EID: 0034254209     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20000801)61:3<288::aid-jnr6>3.0.co;2-%23     Document Type: Article

References (19)

1. Myelination of the canine central nervous system by glial cell transplantation: A model for repair of human myelin disease
2. Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS
3. Suppression of remyelination in the CNS by X-irradiation
4. The effect of the number of oligodendrocytes transplanted into x-irradiated, glial-free lesions on the extent of oligodendrocyte remyelination
5. Remyelination of demyelinated rat axons by transplanted mouse oligodendrocytes
6. Differentiation of glial cell progenitor populations following transplantation into non-repairing CNS glial lesions in adult animals
7. Repair of myelin disease: Stratagies and progress in animal models
8. Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord, but not in noermal spinal cord
9. Transplanting oligodendrocyte progenitors into the adult CNS
10. Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system
11. Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells
12. Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in rat spinal cord
13. PSA-NCAM positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS following transplantation
14. Oligodendrocyte precursors survive poorly and do not migrate following transplantation into the normal adult central nervous system
15. Use of a rat Y-chromosome probe to determine the long term fate of glial cells transplanted into areas of central nervous system demyelination
16. Myelin formation following transplantation of normal fetal glia into myelin-deficient rat spinal cord
17. Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced demyelination
18. Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts
19. Generation of oligodendroglial progenitors from neural stem cells