Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bed

Journal of Physiology

Volumn 539, Issue 3, 2002, Pages 893-902

  Harris, David ^a   McCulloch, Audrey I ^a   Kendall, David A ^a   Randall, Michael D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

18ALPHA GLYCYRRHETINIC ACID; 7 NITROINDAZOLE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR ANTAGONIST; CAPSAICIN; CARBENOXOLONE; N(G) NITROARGININE METHYL ESTER; NEUROTRANSMITTER; NITRIC OXIDE SYNTHASE; OUABAIN; PALMITOLEIC ACID; RIMONABANT; RUTHENIUM RED; VANILLOID RECEPTOR;

ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; GAP JUNCTION; INHIBITION KINETICS; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; ARACHIDONIC ACIDS; BIOLOGICAL FACTORS; CAPSAICIN; DRUG SYNERGISM; ENZYME INHIBITORS; GAP JUNCTIONS; INDOMETHACIN; MALE; MESENTERIC ARTERIES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; POLYUNSATURATED ALKAMIDES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RUTHENIUM RED; VASODILATION; VASODILATOR AGENTS;

EID: 0037088843     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2001.013489     Document Type: Article

References (36)

1. 1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. British Journal of Pharmacology 123, 968-974.
2. CHAYTOR, A. T., MARTIN, P. E. M., EVANS, W. H., RANDALL, M. D. & GRIFFITH, T. M. (1999). The endothelial component of cannabinoid-induced relaxations in rat mesenteric artery depends on gap junctional communication but not nitric oxide. Journal of Physiology 520, 539-550.
3. 1) receptor expression is associated with mesenteric resistance vessels but not thoracic aorta in the rat. British Journal of Pharmacology 125, 95P.
4. DAVIDSON, J. S., BAUMGARTEN, I. M. & HARTLEY, E. H. (1986). Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. Biochemical and Biophysical Research Communications 134, 29-36.
5. DE PETROCELLIS, L., BISOGNO, T., MACCARRONE, M., DAVIS, J. B., FINAZZI-AGRO, A. & DI MARZO, V. (2001). The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. Journal of Biological Chemistry 276, 12856-12863.
6. DEUTSCH, D. G., GOLIGORSKY, M. S., SCHMID, P. G., KREBSBACH, R. J., SCHMID, R. J., DAS, S. K., DEY, S. K., ARREAZA, G., THORUP, C., STEFANO, G. & MOORE, L. C. (1997). Production and physiological actions of anandamide in the vasculature of the rat kidney. Journal of Clinical Investigations 100, 1538-1546.
7. ELLIS, E. F., MOORE, S. F. & WILLOUGHBY, K. A. (1995). Anandamide and D9-THC dilation of cerebral arterioles is blocked by indomethacin. American Journal of Physiology 269, H1859-1864.
8. 1 receptor to stimulation of cAMP accumulation. Journal of Pharmacology and Experimental Therapeutics 284, 291-297.
9. 2+ channel current. American Journal of Physiology 276, H2085-2093.
10. HARRIS, D., KENDALL, D. A. & RANDALL, M. D. (1999). Characterization of cannabinoid receptors mediating EDHF responses in the rat isolated mesentery. Naunyn-Schmiedeberg's Archives of Pharmacology 359, 48-52.
11. +-relaxation. European Journal of Pharmacology 402, 119-128.
12. 2 receptors. Proceedings of the National Academy of Sciences of the USA 96, 14136-14141.
13. 1 receptor knockout mice. Science 283, 401-404.
14. MERHI, M., DUSTING, G. J. & KHALIL, Z. (1998). CGRP and nitric oxide of neuronal origin and their involvement in neurogenic vasodilatation in rat skin microvasculature. British Journal of Pharmacology 123, 863-868.
15. MITCHELL, J. A., WILLIAMS, F. M., WILLIAMS, T. J. & LARKIN, S. W. (1997). Role of nitric oxide in the dilator actions of capsaicin-sensitive nerves in the rabbit coronary circulation. Neuropeptides, 31, 333-338.
16. MOORE, P. K., BABBEDGE, R. C., WALLACE, P., GAFFEN, Z. A. & HART, S. L. (1993). 7-Nitroindazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity without increasing blood pressure. British Journal of Pharmacology 108, 296-297.
17. PLANE, F., HOLLAND, M., WALDRON, G. J., GARLAND, C. J. & BOYLE, J. P. (1997). Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. British Journal of Pharmacology 121, 1509-1511.
18. 1 cannabinoid receptor. American Journal of Physiology 274, H375-381.
19. RALEVIC, V., KENDALL, D. A., RANDALL, M. D., ZYGMUNT, P. M., MOVAHED, P. & HÖGESTÄTT, E. D. (2000). Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries. British Journal of Pharmacology 130, 1483-1488.
20. RANDALL, M. D., ALEXANDER, S. P. H., BENNETT, T., BOYD, E. A., FRY, J. R., GARDINER, S. M., KEMP, P. A., MCCULLOCH, A. I. & KENDALL, D. A. (1996). An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochemical and Biophysical Research Communications 229, 114-120.
21. RANDALL, M. D. & KENDALL, D. A. (1998a). Endocannabinoids: a new class of vasoactive substances. Trends in Pharmacological Sciences 19, 55-58.
22. RANDALL, M. D. & KENDALL, D. A. (1998b). Anandamide and endothelium-derived hyperpolarizing factor act via a common vasorelaxant mechanism in rat mesentery. European Journal of Pharmacology 346, 51-53.
23. RANDALL, M. D., MCCULLOCH, A. I. & KENDALL, D. A. (1997). Comparative pharmacology of endothelium-derived hyperpolarizing factor and anandamide in rat isolated mesentery. European Journal of Pharmacology 333, 191-197.
24. RICHARDSON, J. D., AANONSEN, L. & HARGREAVES, K. M. (1998a). Antihyperalgesic effects of spinal cannabinoids. European Journal of Pharmacology 345, 145-154.
25. 1 receptors. Pain 75, 111-119.
26. 1 receptor mRNA in human vascular cells: is 2-arachidonylglycerol a possible vasomodulator. Biochemical and Biophysical Research Communications 243, 838-843.
27. +-ATPase synthesis and structure-activity relationships. European Journal of Medicinal Chemistry 27, 345-351.
28. WAGNER, J. A., VARGA, K., JARAI, Z. & KUNOS, G. (1999). Mesenteric vasodilation mediated by endothelial anandamide receptors. Hypertension 33, 429-434.
29. WANG, X., WU, Z. X., TANG, Y. M., FISCUS, R. R. & HAN, C. D. (1996). Rapid nitric oxide- and prostaglandin-dependent release of calcitonin gene-related peptide (CGRP) triggered by endotoxin in rat mesenteric arterial bed. British Journal of Pharmacology 118, 2164-2170.
30. WHITE, R. & HILEY, C. R. (1997). A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. British Journal of Pharmacology 122, 1573-1584.
31. WHITE, R. & HILEY, C. R. (1998). The actions of the cannabinoid receptor antagonist, SR141716A, in the rat isolated mesenteric artery. British Journal of Pharmacology 125, 689-696.
32. WHITE, R., HO, W.-S. V., BOTTRILL, F. E., FORD, W. R. & HILEY, C. R. (2001). Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. British Journal of Pharmacology 134, 921-929.
33. ZYGMUNT, P. M., EDWARDS, G., WESTON, A. H., DAVIES, S. C. & HÖGESTÄTT, E. D. (1996). Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. British Journal of Pharmacology 118, 1147-1152.
34. ZYGMUNT, P. M., HÖGESTÄTT, E. D., WALDECK, K., EDWARDS, G., KIRKUP, A. J. & WESTON, A. H. (1997). Studies on the effects of anandamide in rat hepatic artery. British Journal of Pharmacology 122, 1679-1686.
35. ZYGMUNT, P. M., PETFRSSON, J., ANDERSON, D. A., CHUANG, H., SORGARD, M., DI MARZO, V., JULIUS, D. & HÖGESTATT, E. D. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452-457.
36. ZYGMUNT, P. M., SORGARD, M., PETERSSON, J., JOHANSSON, R. & HOGESTÄTT, E. D. (2000). Differential actions of anandamide, potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig basilar artery. Naunyn-Schmiedeberg's Archives of Pharmacology 361, 535-542.