CGRP and nitric oxide of neuronal origin and their involvement in neurogenic vasodilatation in rat skin microvasculature

British Journal of Pharmacology

Volumn 123, Issue 5, 1998, Pages 863-868

  Merhi, Merhi ^a   Dusting, Greg J ^b   Khalil, Zeinab ^a  

^a NATIONAL AGEING RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

CGRP; Endothelin; Microvasculature; NO; Sensory nerves; Vasodilatation

Indexed keywords

7 NITROINDAZOLE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE[8-37]; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLISTER; CONTROLLED STUDY; DOPPLER FLOWMETER; ELECTROSTIMULATION; MALE; NERVE STIMULATION; NEUROGENIC INFLAMMATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSORY NERVE; SKIN BLOOD VESSEL; VASODILATATION;

EID: 0031908281     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701696     Document Type: Article

References (39)

1. BLAND-WARD, P.A. & MOORE, P.K. (1995). 7-Nitroindazole derivatives are potent inhibitors of brain. endothelium and inducible isoforms of nitric oxide synthase, Life Sci., 57, 131-135.
2. BOULANGER, C. & LÜSCHER, T.F. (1990). Release of endothelin from porcine aorta. Inhibition by endothelial-derived nitric oxide. J. Clin. Invest., 85, 587-590.
3. BRAIN, S.D., HUGHES, S.R., CAMBRIDGE, H. & O'DRISCOLL, G. (1993). The contribution of calcitonin gene-related peptide (CGRP) in neurogenic vasodilator responses. Agents Actions. 38, C19-C21.
4. BRANDLI, P., LUFFLER, B-M., BREU, V., OSTERWALDER, R., MAIRE, J-P. & CLOZEL, M. (1995). Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater. Pain, 64, 315-322.
5. BREDT, D.S., HWANG, P.M. & SYNDER, S.H. (1990). Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 373, 768-770.
6. BREDT, D.S. & SYNDER, S.H. (1992). Nitric oxide, a novel neuronal messenger. Neuron, 8, 3-11.
7. CODERRE, T.J., BASBAUM, A.I. & LEVINE, J.D. (1989). Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents. J. Neurophysiol., 62, 48-58.
8. DELAY-GOYET, P., SATOH, H. & LUNDBERG, J.M. (1992). Relative involvement of substance P and CGRP mechanisms in antidromic vasodilatation in the rat skin. Acta Physiol. Scand., 146, 537-538.
9. DIPPEL, E., SCHONFELDER, D., CZARNETSKI, B.M. & PAUS, R. (1993). Localisation and activity of nitric oxide synthase during the murine hair growth cycle. J. Invest. Dermatol., 101, 403.
10. 8-37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve. Br. J. Pharmacol., 110, 772-776.
11. ESCOTT, J.K., BEATTIE, D.T., CONNOR, H.E. & BRAIN, S.D. (1995). Trigeminal ganglion stimulation increases facial blood flow in the rat: a major role for calcitonin gene-related peptide. Brain Res., 669, 93-99.
12. EILEP, J.C., FOLDES-FILEP, E., ROSSEAU, A., SIRIOS, P. & FOURNIER, A. (1993). Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat. Br. J. Pharmacol., 110, 1213-1221.
13. FRANCO-CERECEDA, A., RYDH, M., LOU, Y.P., DALSGAARD, C.J. & LUNDBERG, J.M. (1991). Endothelin as a putattive sensory neuropeptide in the guinea-pig: different properties in comparison with calcitonin gene-related peptide. Regul. Pept., 32, 253-265.
14. GARTHWAITE, J., CHARLES, S.L. & CHESS-WILLIAMS, R. (1988). Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messenger in the brain. Nature, 336, 385-388.
15. GRACE, G.C., DUSTING, G.J., KEMP, B.E. & MARTIN, T.J. (1987). Endothelium and the vasodilator action of rat calcitonin gene-related peptide (CGRP). Br. J. Pharmacol., 91, 729-733.
16. GOLDSMITH, P.C., LEVELL, N.J., FOREMAN, J.C., POLAK, J.M. & DOWD, P.M. (1993). Nitric oxide synthase: immunolocalisation and function in human skin. J. Invest. Dermatol., 101, 419.
17. HAYNES, W.G. & WEBB, D.J. (1994). Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet, 344, 852-854.
18. HOLZER, P. (1988). Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience, 24, 739-768.
19. HOLZER, P. & JOCIČ, M (1994). Cutaneous vasodilatation induced by nitric oxide-evoked stimulation of afferent nerves in the rat. Br. J. Pharmacol., 112, 1181-1187.
20. HUGHES, S.R. & BRAIN, S.D. (1994). Nitric oxide-dependent release of vasodilator quantities of calcitonin gene-related peptide from capsaicin-sensitive nerves in rabbit skin. Br. J. Pharmacol., 111, 425-430.
21. JANIG, W. & LISNEY, J.W. (1989). Small diameter myelinated afferents produce vasodilatation but not plasma extravasation in rat skin. J. Physiol., 415, 477-486.
22. KAJEKAR, R., MOORE, P.K. & BRAIN, S.D. (1995). Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation. Circ. Res., 76, 441-447.
23. KHALIL, Z., ANDREWS, P.V. & HELME, R.D. (1988). VIP modulates substance P-induced plasma extravasation in vivo. Eur. J. Pharmacol., 151, 281-287.
24. KHALIL, Z. & HELME, R.D. (1992). The quantitative contribution of nitric oxide and sensory nerves to bradykinin-induced inflammation in rat skin microvasculature. Brain Res., 589, 102-108.
25. KHALIL, Z., RALEVIC, V., BASSIRAT, M., DUSTING, G.J. & HELME, R.D. (1994). Effects of ageing on sensory nerve function. Brain Res., 641, 265-272.
26. 425-35) at the level of skin microvasculature. Brain Res., 736, 206-216.
27. B receptors in rat skin and an investigation of their function in the cutaneous microvasculature. Br. J. Pharmacol., 115, 840-844.
28. LEMBECK, F. & HOLZER, P. (1979). Substance P as a neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg's Arch. Pharmacol., 310, 175-183.
29. LEVIN, E.R. (1996). Endothelins as cardiovascular peptides. Am. J. Nephrol., 16, 246-251.
30. MELLER, S.T. & GEBHART, G.F. (1993). Nitric oxide and nociceptive processing in the spinal cord. Pain, 52, 127-136.
31. MORRIS, R., SOUTHAM, E., BRAIN, D.J. & GARTHWAITE, J. (1992). Nitric oxide may act as a messenger between dorsal root ganglion neurones and their satellite cells. Neurosci. Lett., 137, 29-32.
32. MORRIS, R., SOUTHAM, E., GITTINS, S.R., DE VENTE, J. & GARTHWAITE, J. (1994). The NO-cGMP pathway in neonatal rat dorsal horn. Eur. J. Neurosci., 6, 876-879.
33. MOORE, P.K., BABBEDGE, R.C., WALLACE, P., GAFFEN, Z.A. & HART, S.L. (1993). 7-Nitroindazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol., 108, 296-297.
34. NAGY, J.I. HUNT, S.P., IVERSEN, L.L. & EMSON, P.C. (1981). Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin. Neuroscience, 6, 1923-1934.
35. RALEVIC, V., KHALIL, Z., DUSTING, G.J. & HELME, R.D. (1992). Nitric oxide and sensory nerves are involved in the vasodilator response to acetylcholine but not calcitonin gene-related peptide in rat skin microvasculature. Br. J. Pharmacol., 106, 650-655.
36. RALEVIC, V., KHALIL, Z., HELME, R.D. & DUSTING, G.J. (1995). Role of nitric oxide in the actions of substance P and other mediators of inflammation in rat skin microvasculature. Eur. J. Pharmacol., 284, 231-239.
37. REES, D.D., PALMER, R.M.J., SCHULZ, R., HODSON, H.F. & MONCADA, S. (1990). Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol., 101, 746-752.
38. WHITE, D.M. & HELME, R.D. (1985). Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve. Brain Res., 336, 27-31.
39. ZAGVAZDIN, Y., SANCESARIO, G., WANG, Y-X., SHARE, L., FITZGERALD, M.E. & REINER, A. (1996). Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo. Eur. J. Pharmacol., 303, 61-69.