N-aryl N′-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: Structure-activity relationship

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 944-954

  Renodon Cornière, Axelle ^a   Dijols, Sylvie ^a   Perollier, Céline ^a   Lefevre Groboillot, David ^a   Boucher, Jean Luc ^a   Attias, Roger ^a   Sari, Marie Agnes ^a   Stuehr, Dennis ^b   Mansuy, Daniel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOXIME; AMINE; CHLORINE; ETHER; FLUORINE; FUNCTIONAL GROUP; GUANIDINE DERIVATIVE; HYDROGEN; HYDROXYL GROUP; METHYL GROUP; N' HYDROXYGUANIDINE DERIVATIVE; N(G) HYDROXYARGININE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OXIME; OXYGEN; PHENYL GROUP; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROBIOPTERIN; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ELECTRON; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROPHOBICITY; MICHAELIS CONSTANT; OXIDATION; STEREOCHEMISTRY; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUANIDINES; KINETICS; NADP; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; OXYGEN; OXYHEMOGLOBINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037075130     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011006h     Document Type: Article

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